Multifunctional Nanoregulator Reshapes Immune Microenvironment and Enhances Immune Memory for Tumor Immunotherapy

MRI-Visible siRNA Nanomedicine Directing Neuronal Differentiation of Neural Stem Cells in Stroke

(2018) Liejing Lu et al.   ADVANCED FUNCTIONAL MATERIALS

Perfluorohexane-cored nanodroplets for stimulations-responsive ultrasonography and O 2 -potentiated photodynamic therapy

(2018) Meng Yu et al.   BIOMATERIALS

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

(2017) Georg Fluegen et al.   NATURE CELL BIOLOGY

Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery

(2017) Fei-Fei An et al.   Theranostics

Carbon-Dot-Decorated Carbon Nitride Nanoparticles for Enhanced Photodynamic Therapy against Hypoxic Tumor via Water Splitting

(2016) Di-Wei Zheng et al.   ACS Nano

Cancer Therapy: Perfluorocarbon-Loaded Hollow Bi2 Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer (Adv. Mater. 14/2016)

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Intelligent Albumin-MnO2Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy

(2016) Qian Chen et al.   ADVANCED MATERIALS

A Breakthrough: Macrophage-Directed Cancer Immunotherapy

(2016) C. D. Mills et al.   CANCER RESEARCH

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model

(2016) João Conde et al.   NATURE MATERIALS

Designer vaccine nanodiscs for personalized cancer immunotherapy

(2016) Rui Kuai et al.   NATURE MATERIALS

The future of cancer treatment: immunomodulation, CARs and combination immunotherapy

(2016) Danny N. Khalil et al.   Nature Reviews Clinical Oncology

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Drug-Induced Self-Assembly of Modified Albumins as Nano-theranostics for Tumor-Targeted Combination Therapy

(2015) Qian Chen et al.   ACS Nano

Hybrid Nanoparticles: Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment (Adv. Funct. Mater. 12/2015)

(2015) Claudia R. Gordijo et al.   ADVANCED FUNCTIONAL MATERIALS

Intelligent MnO2Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH-/H2O2-Responsive UCL Imaging and Oxygen-Elevated Synergetic Therapy

(2015) Wenpei Fan et al.   ADVANCED MATERIALS

Core-Shell MnSe@Bi2Se3Fabricated via a Cation Exchange Method as Novel Nanotheranostics for Multimodal Imaging and Synergistic Thermoradiotherapy

(2015) Guosheng Song et al.   ADVANCED MATERIALS

A Smart DNAzyme-MnO2Nanosystem for Efficient Gene Silencing

(2015) Huanhuan Fan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Nanomaterial-based activatable imaging probes: from design to biological applications

(2015) Jingjing Li et al.   CHEMICAL SOCIETY REVIEWS

Myeloid Cells and Related Chronic Inflammatory Factors as Novel Predictive Markers in Melanoma Treatment with Ipilimumab

(2015) C. Gebhardt et al.   CLINICAL CANCER RESEARCH

Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected

(2015) Douglas Marvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

(2015) Christina Twyman-Saint Victor et al.   NATURE

Combination cancer immunotherapies tailored to the tumour microenvironment

(2015) Mark J. Smyth et al.   Nature Reviews Clinical Oncology

Immunological mechanisms of the antitumor effects of supplemental oxygenation

(2015) Stephen M. Hatfield et al.   Science Translational Medicine

Multifunctional Albumin–MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, Vascular Endothelial Growth Factor and Enhance Radiation Response

(2014) Preethy Prasad et al.   ACS Nano

Break-up of Two-Dimensional MnO2Nanosheets Promotes Ultrasensitive pH-Triggered Theranostics of Cancer

(2014) Yu Chen et al.   ADVANCED MATERIALS

Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs

(2014) Qihang Sun et al.   ADVANCED MATERIALS

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors—Response

(2014) Jaikumar Duraiswamy et al.   CANCER RESEARCH

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell Protective, ABC Triblock Polymer-Based Thermoresponsive Hydrogels with ROS-Triggered Degradation and Drug Release

(2014) Mukesh K. Gupta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Myeloid-Derived Suppressor Cells in Cancer: Therapeutic, Predictive, and Prognostic Implications

(2014) C. Marcela Diaz-Montero et al.   SEMINARS IN ONCOLOGY

Hostile, Hypoxia-A2-Adenosinergic Tumor Biology as the Next Barrier to Overcome for Tumor Immunologists

(2014) M. V. Sitkovsky et al.   Cancer Immunology Research

Collective Activation of MRI Agents via Encapsulation and Disease-Triggered Release

(2013) Mathieu L. Viger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hyperoxic Acute Lung Injury

(2013) R. H. Kallet et al.   Respiratory Care

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

Angiogenesis and immunity: a bidirectional link potentially relevant for the monitoring of antiangiogenic therapy and the development of novel therapeutic combination with immunotherapy

(2011) Eric Tartour et al.   CANCER AND METASTASIS REVIEWS

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Self-Confirming “AND” Logic Nanoparticles for Fault-Free MRI

(2010) Jin-sil Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein-Directed Synthesis of Highly Fluorescent Gold Nanoclusters

(2009) Jianping Xie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models

(2009) F. Shojaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

(2009) Michail V. Sitkovsky   TRENDS IN IMMUNOLOGY

Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives

(2008) Paulo C. Rodríguez et al.   IMMUNOLOGICAL REVIEWS

Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles

(2008) Felix Kratz   JOURNAL OF CONTROLLED RELEASE

Nanoparticle therapeutics: an emerging treatment modality for cancer

(2008) Mark E. Davis et al.   NATURE REVIEWS DRUG DISCOVERY

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark