High-throughput screening of drug-binding dynamics to HERG improves early drug safety assessment

An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment

(2011) M. R. Davies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Automated electrophysiology makes the pace for cardiac ion channel safety screening

(2011) Clemens Möller   Frontiers in Pharmacology

Reducing QT liability and proarrhythmic risk in drug discovery and development

(2010) Jean-Pierre Valentin   BRITISH JOURNAL OF PHARMACOLOGY

Minimizing Repolarization-Related Proarrhythmic Risk in Drug Development and Clinical Practice

(2010) Attila S. Farkas et al.   DRUGS

Effects of the Antiarrhythmic Drug Dofetilide on Transmural Dispersion of Repolarization in Ventriculum. A Computer Modeling Study

(2010) Javier Saiz et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Identification of I Kr Kinetics and Drug Binding in Native Myocytes

(2009) Qinlian Zhou et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Markov models for ion channels: versatility versus identifiability and speed

(2009) M. Fink et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

(2009) Matthew E.L. Hardy et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

(2008) John S. Mitcheson   CHEMICAL RESEARCH IN TOXICOLOGY

Multiscale modelling of drug-induced effects on cardiac electrophysiological activity

(2008) T. Brennan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

(2008) Sebastian Polak et al.   JOURNAL OF APPLIED TOXICOLOGY

State dependent dissociation of HERG channel inhibitors

(2007) D Stork et al.   BRITISH JOURNAL OF PHARMACOLOGY

The canine virtual ventricular wall: A platform for dissecting pharmacological effects on propagation and arrhythmogenesis

(2007) Alan P. Benson et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY