Drug-induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects

(2012) Christine E. Garnett et al.   AMERICAN HEART JOURNAL

A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval

(2012) Jong Wook Kim et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects

(2011) Atsushi Sugiyama et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers

(2011) Prince J. Kannankeril et al.   HEART RHYTHM

Population Pharmacokinetic and Concentration-QTc Models for Moxifloxacin: Pooled Analysis of 20 Thorough QT Studies

(2011) Jeffry A. Florian et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Reevaluation of Moxifloxacin Pharmacokinetics and Their Direct Effect on the QT Interval

(2011) Philippe Grosjean et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers

(2011) Vaibhav Salvi et al.   JOURNAL OF ELECTROCARDIOLOGY

Statistical Characteristics of Moxifloxacin-Induced QTc Effect

(2010) Lihan K. Yan et al.   Journal of Biopharmaceutical Statistics

Pharmacokinetics and Pharmacodynamics of Three Moxifloxacin Dosage Forms: Implications for Blinding in Active-Controlled Cardiac Repolarization Studies

(2010) Jay W. Mason et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effect of Number of Replicate Electrocardiograms Recorded at Each Time Point in a Thorough QT Study on Sample Size and Study Cost

(2010) Mili Natekar et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Assessment of QTc-prolonging potential of BX471 in healthy volunteers. A ‘thorough QTcstudy’ following ICH E14 using various QT correction methods

(2009) Marc Vandemeulebroecke et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers

(2009) Jorg Taubel et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Absence of Effect of Telbivudine on Cardiac Repolarization: Results of a Thorough QT/QTc Study in Healthy Participants

(2009) Fred Poordad et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Electrocardiographic QTc Changes Due to Moxifloxacin Infusion

(2009) Marek Malik et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Phenotypic Variability in Caucasian and Japanese Patients with Matched LQT1 Mutations

(2008) Judy F. Liu et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

The Role of Ethnicity in Variability in Response to Drugs: Focus on Clinical Pharmacology Studies

(2008) SU Yasuda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Overrepresentation of the proarrhythmic, sudden death predisposing sodium channel polymorphism S1103Y in a population-based cohort of African-American sudden infant death syndrome

(2008) David W. Van Norstrand et al.   HEART RHYTHM

Flaws in the U.S. Food and Drug Administration's Rationale for Supporting the Development and Approval of BiDil as a Treatment for Heart Failure Only in Black Patients

(2008) George T. H. Ellison et al.   JOURNAL OF LAW MEDICINE & ETHICS