An overview of the anti-SARS-CoV-2 properties of Artemisia annua, its antiviral action, protein-associated mechanisms, and repurposing for COVID-19 treatment

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

(2020) Canrong Wu et al.   Acta Pharmaceutica Sinica B

Dried Leaf Artemisia Annua Improves Bioavailability of Artemisinin via Cytochrome P450 Inhibition and Enhances Artemisinin Efficacy Downstream

(2020) Matthew R. Desrosiers et al.   Biomolecules

Of chloroquine and COVID-19

(2020) Franck Touret et al.   ANTIVIRAL RESEARCH

Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms

(2020) Emily A. Troyer et al.   BRAIN BEHAVIOR AND IMMUNITY

Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection

(2020) David N. Juurlink   CANADIAN MEDICAL ASSOCIATION JOURNAL

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Clinical evidence for repurposing chloroquine and hydroxychloroquine as antiviral agents: a systematic review

(2020) Chaturaka Rodrigo et al.   CLINICAL MICROBIOLOGY AND INFECTION

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

(2020) Jacques Fantini et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Essential Oils as Antiviral Agents, Potential of Essential Oils to Treat SARS-CoV-2 Infection: An In-Silico Investigation

(2020) Joyce Kelly R. da Silva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A systematic review of the prophylactic role of chloroquine and hydroxychloroquine in coronavirus disease‐19 (COVID‐19)

(2020) Sanket Shah et al.   International Journal of Rheumatic Diseases

An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study

(2020) Sourav Das et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

Potential effects of curcumin in the treatment of COVID ‐19 infection

(2020) Fatemeh Zahedipour et al.   PHYTOTHERAPY RESEARCH

Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?

(2020) Tuğçenur Uzun et al.   Chinese Medicine

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak

(2020) Xi-Xi Yin et al.   ACS Chemical Neuroscience

Artemisia Spp. Derivatives for COVID-19 Treatment: Anecdotal Use, Political Hype, Treatment Potential, Challenges, and Road Map to Randomized Clinical Trials

(2020) Paulin M. Kapepula et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A brewing storm: The neuropsychological sequelae of hyperinflammation due to COVID-19

(2020) Thomas P. Cothran et al.   BRAIN BEHAVIOR AND IMMUNITY

SARS-CoV-2 and Guillain-Barré syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism

(2020) Guglielmo Lucchese et al.   CELL STRESS & CHAPERONES

Human molecular chaperones share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19

(2020) Antonella Marino Gammazza et al.   CELL STRESS & CHAPERONES

Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases

(2020) Aristo Vojdani et al.   CLINICAL IMMUNOLOGY

Artemisia annua, a Traditional Plant Brought to Light

(2020) Axelle Septembre-Malaterre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Clinical recurrences of COVID-19 symptoms after recovery: viral relapse, reinfection or inflammatory rebound?

(2020) Dominique Batisse et al.   JOURNAL OF INFECTION

Retest positive for SARS‐CoV‐2 RNA of “recovered” patients with COVID‐19: Persistence, sampling issues, or re‐infection?

(2020) Hanyujie Kang et al.   JOURNAL OF MEDICAL VIROLOGY

Antiviral Effects of Plant-Derived Essential Oils and Their Components: An Updated Review

(2020) Li Ma et al.   MOLECULES

Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases

(2020) Dorothy H.J. Cheong et al.   PHARMACOLOGICAL RESEARCH

COVID-19 and the Immune System

(2020) J PACES et al.   PHYSIOLOGICAL RESEARCH

Anti-SARS-CoV-2 Potential of Artemisinins In Vitro

(2020) Ruiyuan Cao et al.   ACS Infectious Diseases

Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis

(2020) Francesco Cappello et al.   Journal of Clinical Medicine

Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate

(2020) Mathieu Gendrot et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Distinct and early increase in circulating MMP-9 in COVID-19 patients with respiratory failure

(2020) T Ueland et al.   JOURNAL OF INFECTION

Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of Coronavirus

(2020) C.N. Prashantha et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation

(2020) Mathieu Gendrot et al.   Travel Medicine and Infectious Disease

Safety and efficacy of artemisinin-piperaquine for treatment of COVID-19: an open-label, non-randomised and controlled trial

(2020) Guoming Li et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Dihydroartemisinin regulates the immune system by promotion of CD8+ T lymphocytes and suppression of B cell responses

(2019) Ting Zhang et al.   Science China-Life Sciences

Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle

(2019) Yingying Cong et al.   JOURNAL OF VIROLOGY

Unexpected mechanism of colitis amelioration by artesunate, a natural product from Artemisia annua L.

(2019) Weili Sun et al.   INFLAMMOPHARMACOLOGY

Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages

(2018) Yu-xi Yan et al.   ACTA PHARMACOLOGICA SINICA

Artemisinin permeability via Caco-2 cells increases after simulated digestion of Artemisia annua leaves

(2018) Matthew R. Desrosiers et al.   JOURNAL OF ETHNOPHARMACOLOGY

Combination of artemisinin-based natural compounds from Artemisia annua L. for the treatment of malaria: Pharmacodynamic and pharmacokinetic studies

(2018) Jing Li et al.   PHYTOTHERAPY RESEARCH

Artemisia annua dried leaf tablets treated malaria resistant to ACT and i.v. artesunate: Case reports

(2017) Nsengiyumva Bati Daddy et al.   PHYTOMEDICINE

Effect of leaf digestion and artemisinin solubility for use in oral consumption of dried Artemisia annua leaves to treat malaria

(2016) Matthew R. Desrosiers et al.   JOURNAL OF ETHNOPHARMACOLOGY

RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load

(2015) Palmiro Poltronieri et al.   CURRENT GENOMICS

Th1-Biased Immunomodulation and Therapeutic Potential of Artemisia annua in Murine Visceral Leishmaniasis

(2015) Mohammad Islamuddin et al.   PLoS Neglected Tropical Diseases

Toxic essential oils. Part II: Chemical, toxicological, pharmacological and microbiological profiles of Artemisia annua L. volatiles

(2013) Niko S. Radulović et al.   FOOD AND CHEMICAL TOXICOLOGY

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

Herbal Therapeutics that Block the Oncogenic Kinase PAK1: A Practical Approach towards PAK1-dependent Diseases and Longevity

(2013) Hiroshi Maruta   PHYTOTHERAPY RESEARCH

Molecular Docking: A Powerful Approach for Structure-Based Drug Discovery

(2012) Xuan-Yu Meng et al.   Current Computer-Aided Drug Design

Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua

(2012) Andrea Lubbe et al.   JOURNAL OF ETHNOPHARMACOLOGY

A reporter system for Epstein-Barr virus (EBV) lytic replication: Anti-EBV activity of the broad anti-herpesviral drug artesunate

(2011) Sabrina Auerochs et al.   JOURNAL OF VIROLOGICAL METHODS

PAK1 as a therapeutic target

(2010) Julia V Kichina et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer

(2010) Jorge F.S. Ferreira et al.   MOLECULES

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES