Journal
CELL STRESS & CHAPERONES
Volume 25, Issue 5, Pages 731-735Publisher
SPRINGER
DOI: 10.1007/s12192-020-01145-6
Keywords
COVID-19; Neuropathy; Demyelination
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Funding
- University of Greifswald
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [327654276 SFB 1315]
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Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barre syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barre syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
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