PAK1 as a therapeutic target

Elevated p21-Activated Kinase 2 Activity Results in Anchorage-Independent Growth and Resistance to Anticancer Drug–Induced Cell Death

(2015) Jerry W. Marlin et al.   NEOPLASIA

Estrogen Receptor-  Phosphorylation at Serine 305, Nuclear p21-Activated Kinase 1 Expression, and Response to Tamoxifen in Postmenopausal Breast Cancer

(2010) J. Bostner et al.   CLINICAL CANCER RESEARCH

An emerging role for p21-activated kinases (Paks) in viral infections

(2010) Celine Van den Broeke et al.   TRENDS IN CELL BIOLOGY

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics

(2009) J. D. Allen et al.   BLOOD

Tumor necrosis factor-alpha induced expression of matrix metalloproteinase-9 through p21-activated Kinase-1

(2009) Ling Zhou et al.   BMC IMMUNOLOGY

Targeting group II PAKs in cancer and metastasis

(2009) Jeyanthy Eswaran et al.   CANCER AND METASTASIS REVIEWS

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

PAK1 and PAK2 have different roles in HGF-induced morphological responses

(2009) Michael D. Bright et al.   CELLULAR SIGNALLING

PAKing up to the endothelium

(2009) Eva Maria Galan Moya et al.   CELLULAR SIGNALLING

VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation

(2009) Sabu Abraham et al.   CURRENT BIOLOGY

p21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo

(2009) Akinari Hinoki et al.   HYPERTENSION

Group I p21-activated kinases: Emerging roles in immune function and viral pathogenesis

(2009) Almudena Pacheco et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1

(2009) Funan Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion

(2009) Michelle K.Y. Siu et al.   INTERNATIONAL JOURNAL OF CANCER

Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling

(2009) M.-F. Lise et al.   JOURNAL OF CELL SCIENCE

Formation of endothelial lumens requires a coordinated PKC -, Src-, Pak- and Raf-kinase-dependent signaling cascade downstream of Cdc42 activation

(2009) W. Koh et al.   JOURNAL OF CELL SCIENCE

PAK thread from amoeba to mammals

(2009) Anupam Kumar et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

α Pix enhances mutant huntingtin aggregation

(2009) Makoto Eriguchi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

(2009) J. Viaud et al.   MOLECULAR CANCER THERAPEUTICS

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

The role of PAK-1 in activation of MAP kinase cascade and oncogenic transformation by Akt

(2009) P R Somanath et al.   ONCOGENE

LIM-kinase 2, a regulator of actin dynamics, is involved in mitotic spindle integrity and sensitivity to microtubule-destabilizing drugs

(2009) S T Po'uha et al.   ONCOGENE

Interaction with LC8 Is Required for Pak1 Nuclear Import and Is Indispensable for Zebrafish Development

(2009) Christine M. Lightcap et al.   PLoS One

Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases

(2009) C. Van den Broeke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TheDrosophilap21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo

(2008) Nicolas Menzel et al.   BIOCHEMICAL JOURNAL

A tale of two Paks

(2008) Luis E. Arias-Romero et al.   BIOLOGY OF THE CELL

Validation of the p21-Activated Kinases as Targets for Inhibition in Neurofibromatosis Type 2

(2008) C. Yi et al.   CANCER RESEARCH

MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions

(2008) S. D. N. Reddy et al.   CANCER RESEARCH

PAK signalling in neuronal physiology

(2008) Patricia Kreis et al.   CELLULAR SIGNALLING

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Rho signaling and mechanical control of vascular development

(2008) Akiko Mammoto et al.   CURRENT OPINION IN HEMATOLOGY

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

(2008) Tanya Nekrasova et al.   DEVELOPMENTAL BIOLOGY

The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS

(2008) Prisca Liberali et al.   EMBO JOURNAL

Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3

(2008) Beat Amstutz et al.   EMBO JOURNAL

Targeting survivin in cancer therapy

(2008) Marzia Pennati et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Affixin activates Rac1 via βPIX in C2C12 myoblast

(2008) Chie Matsuda et al.   FEBS LETTERS

Amplification of 11q13 in ovarian carcinoma

(2008) Lindsay A. Brown et al.   GENES CHROMOSOMES & CANCER

p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis

(2008) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation

(2008) I. Ayala et al.   JOURNAL OF CELL SCIENCE

PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics

(2008) S. D. Smith et al.   JOURNAL OF CELL SCIENCE

PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival

(2008) Elizabeth W. Bradley et al.   JOURNAL OF CELLULAR PHYSIOLOGY

14-3-3β-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly

(2008) Payaningal R. Somanath et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Large Kinase Active Site with Rigid, Bulky Octahedral Ruthenium Complexes

(2008) Jasna Maksimoska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms

(2008) S. J. Coniglio et al.   MOLECULAR AND CELLULAR BIOLOGY

Progress in matrix metalloproteinase research

(2008) G MURPHY et al.   MOLECULAR ASPECTS OF MEDICINE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Scaffolding function of PAK in the PDK1–Akt pathway

(2008) Maiko Higuchi et al.   NATURE CELL BIOLOGY

P21-activated kinase is required for mitotic progression and regulates Plk1

(2008) B Maroto et al.   ONCOGENE

Regulation and role of p21-activated kinase 3 by corticotropin-releasing factor in mouse pituitary

(2008) Kazunori Kageyama et al.   REGULATORY PEPTIDES

HIV-1 Nef: at the crossroads

(2008) John L Foster et al.   Retrovirology

Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells

(2008) J. Mercer et al.   SCIENCE

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY

Matrix metalloproteinases at cancer tumor–host interface

(2007) A NOEL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY