Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC

(2021) Mengke Niu et al.   Experimental Hematology & Oncology

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment

(2020) Stephanie van de Wall et al.   TRENDS IN IMMUNOLOGY

Liver Cancer Immunity

(2020) Sumera Rizvi et al.   HEPATOLOGY

Microenvironment characterization and multi-omics signatures related to prognosis and immunotherapy response of hepatocellular carcinoma

(2020) Furong Liu et al.   Experimental Hematology & Oncology

Tumour-associated macrophages-derived CXCL8 determines immune evasion through autonomous PD-L1 expression in gastric cancer

(2019) Chao Lin et al.   GUT

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

(2019) Jun Wang et al.   NATURE MEDICINE

Blocking TREM-1+ Tumor-associated macrophages induced by hypoxia reverses immunosuppression and anti-PD-L1 resistance in liver cancer

(2019) Qinchuan Wu et al.   HEPATOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer

(2019) John Daly et al.   Frontiers in Immunology

Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response

(2019) Yangyang Qi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions

(2018) Masao Hashimoto et al.   Annual Review of Medicine

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini–Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia

(2018) Elias Jabbour et al.   JAMA Oncology

Antibodies Against Immune Checkpoint Molecules Restore Functions of Tumor-Infiltrating T Cells in Hepatocellular Carcinomas

(2017) Guoying Zhou et al.   GASTROENTEROLOGY

Viewing Siglecs through the lens of tumor immunology

(2017) Isabella Fraschilla et al.   IMMUNOLOGICAL REVIEWS

Global trends and predictions in hepatocellular carcinoma mortality

(2017) Paola Bertuccio et al.   JOURNAL OF HEPATOLOGY

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non–Small Cell Lung Cancer

(2017) Dennis O. Adeegbe et al.   Cancer Discovery

The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9

(2016) Richard Beatson et al.   NATURE IMMUNOLOGY

Monoclonal antibodies in acute lymphoblastic leukemia

(2015) E. Jabbour et al.   BLOOD

CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy

(2015) J. Escamilla et al.   CANCER RESEARCH

Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma

(2015) Pei Zhang et al.   JOURNAL OF SURGICAL RESEARCH

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense

(2014) Kayluz Frias Boligan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity

(2014) G.-Y. Chen et al.   GLYCOBIOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

(2014) Guo-Yun Chen et al.   eLife

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

(2013) Esther Bandala-Sanchez et al.   NATURE IMMUNOLOGY

Gemtuzumab Ozogamicin: Time to Resurrect?

(2012) Farhad Ravandi et al.   JOURNAL OF CLINICAL ONCOLOGY

Selectin Ligand Sialyl-Lewis x Antigen Drives Metastasis of Hormone-Dependent Breast Cancers

(2011) S. Julien et al.   CANCER RESEARCH

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

Improving RNA-Seq expression estimates by correcting for fragment bias

(2011) Adam Roberts et al.   GENOME BIOLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

(2009) Bao Hoa Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4

(2009) T Uemura et al.   ONCOGENE

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY