Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response

Identification and Validation of Stromal Immunotype Predict Survival and Benefit from Adjuvant Chemotherapy in Patients with Muscle-Invasive Bladder Cancer

(2018) Hangcheng Fu et al.   CLINICAL CANCER RESEARCH

Phase 2 Trial of Gemcitabine, Cisplatin, plus Ipilimumab in Patients with Metastatic Urothelial Cancer and Impact of DNA Damage Response Gene Mutations on Outcomes

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CD206-positive myeloid cells bind galectin-9 and promote a tumor-supportive microenvironment

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A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

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Tumor stroma-infiltrating mast cells predict prognosis and adjuvant chemotherapeutic benefits in patients with muscle invasive bladder cancer

(2018) Zheng Liu et al.   OncoImmunology

Updated 2016 EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer

(2017) J. Alfred Witjes et al.   EUROPEAN UROLOGY

Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation

(2017) Lucy Golden-Mason et al.   HEPATOLOGY

Bladder Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology

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(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Prognostic value of tumoral expression of galectin-9 in gastric cancer

(2017) Sang Il Choi et al.   Turkish Journal of Gastroenterology

Galectin-9 as a prognostic and predictive biomarker in bladder urothelial carcinoma

(2017) Yidong Liu et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Long-term Survival and Clinical Benefit from Adoptive T-cell Transfer in Stage IV Melanoma Patients Is Determined by a Four-Parameter Tumor Immune Signature

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PD-L1, Galectin-9 and CD8+ tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma

(2017) Kostandinos Sideras et al.   OncoImmunology

Bladder cancer

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Cancer immune contexture and immunotherapy

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Nivolumab monotherapy in recurrent metastatic urothelial carcinoma (CheckMate 032): a multicentre, open-label, two-stage, multi-arm, phase 1/2 trial

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Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma

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Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway

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Survival of Lung Adenocarcinoma Patients Predicted from Expression of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and Tumor-Infiltrating T Cells

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Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

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Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy

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TNF Counterbalances the Emergence of M2 Tumor Macrophages

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Prognostic Significance of CD204-Positive Macrophages in Upper Urinary Tract Cancer

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Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis

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Infiltration of CD3+ and CD68+ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors11Grant support: The Swedish Cancer Society, the Swedish research council, the Nilsson Cancer foundation, the BioCARE Strategic Cancer Research program, the Lund Medical Faculty, and FoU Landstinget Kronoberg and Södra Regionvårdnämnden.

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Galectin-9 in tumor biology: A jack of multiple trades

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High level of mature tumor-infiltrating dendritic cells predicts progression to muscle invasion in bladder cancer

(2013) Cherifa Ayari et al.   HUMAN PATHOLOGY

Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma

(2012) Hang Li et al.   HEPATOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

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FOXP3 and survival in urinary bladder cancer

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Gene Pathways Associated With Prognosis and Chemotherapy Sensitivity in Molecular Subtypes of Breast Cancer

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Bladder Tumor Infiltrating Mature Dendritic Cells and Macrophages as Predictors of Response to Bacillus Calmette-Guérin Immunotherapy

(2009) Cherifa Ayari et al.   EUROPEAN UROLOGY

Gene-Expression Signatures in Breast Cancer

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