Epigenetic Mechanisms Underlying COVID-19 Pathogenesis

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

(2021) Armin Bayati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

(2021) Cornelia Blume et al.   NATURE GENETICS

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

(2021) Yunkai Zhu et al.   Nature Communications

Clinical validation of a novel quantitative assay for the detection of MGMT methylation in glioblastoma patients

(2021) Rocio Rosas-Alonso et al.   Clinical Epigenetics

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

(2021) Qu Deng et al.   iScience

Role of circRNAs in viral infection and their significance for diagnosis and treatment (Review)

(2021) Yuyao Mo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Current and innovative methods for the diagnosis of COVID‑19 infection (Review)

(2021) Luca Falzone et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Various theranostics and immunization strategies based on nanotechnology against Covid-19 pandemic: An interdisciplinary view

(2021) Sujan Chatterjee et al.   LIFE SCIENCES

Prevalence and characteristics of fever in adult and paediatric patients with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis of 17515 patients

(2021) Md Asiful Islam et al.   PLoS One

DNA methylation architecture of the ACE2 gene in nasal cells of children

(2021) Andres Cardenas et al.   Scientific Reports

Leveraging epigenetics to enhance the efficacy of immunotherapy

(2021) Jonathan D. Licht et al.   Clinical Epigenetics

Genome-Wide Chromatin Analysis of FFPE Tissues Using a Dual-Arm Robot with Clinical Potential

(2021) Syuzo Kaneko et al.   Cancers

Integrated Analysis of Whole Genome and Epigenome Data Using Machine Learning Technology: Toward the Establishment of Precision Oncology

(2021) Ken Asada et al.   Frontiers in Oncology

Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies

(2021) Anand A. Patel et al.   Blood Advances

Blood DNA methylation and COVID-19 outcomes

(2021) Joseph Balnis et al.   Clinical Epigenetics

The COVID-19 pandemic: a threat to antimicrobial resistance containment

(2021) Raspail C Founou et al.   Future Science OA

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Epigenetics Analysis and Integrated Analysis of Multiomics Data, Including Epigenetic Data, Using Artificial Intelligence in the Era of Precision Medicine

(2020) Ryuji Hamamoto et al.   Biomolecules

The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review

(2020) Hope S. Rugo et al.   ADVANCES IN THERAPY

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

Epidemiology of COVID-19 Among Children in China

(2020) Yuanyuan Dong et al.   PEDIATRICS

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19

(2020) Wenhua Liang et al.   JAMA Internal Medicine

Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2

(2020) Salvatore Di Giorgio et al.   Science Advances

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

Molecular immune pathogenesis and diagnosis of COVID-19

(2020) Xiaowei Li et al.   Journal of Pharmaceutical Analysis

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

(2020) Bruna G G Pinto et al.   JOURNAL OF INFECTIOUS DISEASES

Shell disorder analysis suggests that pangolins offered a window for a silent spread of an attenuated SARS-CoV-2 precursor among humans

(2020) Gerard Kian-Meng Goh et al.   JOURNAL OF PROTEOME RESEARCH

Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis

(2020) Akosua Adom Agyeman et al.   MAYO CLINIC PROCEEDINGS

A molecular pore spans the double membrane of the coronavirus replication organelle

(2020) Georg Wolff et al.   SCIENCE

Drug treatments for covid-19: living systematic review and network meta-analysis

(2020) Reed AC Siemieniuk et al.   BMJ-British Medical Journal

Protein Coding and Long Noncoding RNA (lncRNA) Transcriptional Landscape in SARS-CoV-2 Infected Bronchial Epithelial Cells Highlight a Role for Interferon and Inflammatory Response

(2020) Radhakrishnan Vishnubalaji et al.   Genes

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection

(2020) Ken Asada et al.   Biomolecules

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

Identification of required host factors for SARS-CoV-2 infection in human cells

(2020) Zharko Daniloski et al.   CELL

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

Epigenetic regulation of ACE2, the receptor of the SARS-CoV-2 virus

(2020) Tasnim BEACON et al.   GENOME

Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option

(2020) Kevin W. Ng et al.   NATURE GENETICS

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

(2020) Olusegun O. Onabajo et al.   NATURE GENETICS

Evolution of the COVID-19 vaccine development landscape

(2020) Tung Thanh Le et al.   NATURE REVIEWS DRUG DISCOVERY

Host Immune Response Driving SARS-CoV-2 Evolution

(2020) Rui Wang et al.   Viruses-Basel

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses

(2020) Masato Kosuge et al.   Scientific Reports

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

(2020) Luca Falzone et al.   Cancers

The structural basis of accelerated host cell entry by SARS‐CoV‐2†

(2020) Murat Seyran et al.   FEBS Journal

Unravelling host-pathogen interactions: ceRNA network in SARS-CoV-2 infection (COVID-19)

(2020) Shweta Arora et al.   GENE

Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 ( COVID ‐19): A Meta‐analysis of 27,492 Patients

(2020) Jeyasakthy Saniasiaya et al.   LARYNGOSCOPE

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

(2020) Sk. Sarif Hassan et al.   MOLECULES

Gene regulation by long non-coding RNAs and its biological functions

(2020) Luisa Statello et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevalence and Characteristics of Taste Disorders in Cases of COVID-19: A Meta-analysis of 29,349 Patients

(2020) Jeyasakthy Saniasiaya et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

(2020) Yuanyuan Qiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of Headache in Patients With Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of 14,275 Patients

(2020) Md Asiful Islam et al.   Frontiers in Neurology

The SARS-CoV-2 RNA–protein interactome in infected human cells

(2020) Nora Schmidt et al.   Nature Microbiology

Application of Artificial Intelligence Technology in Oncology: Towards the Establishment of Precision Medicine

(2020) Ryuji Hamamoto et al.   Cancers

The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses

(2020) Jacinta M. Wubben et al.   Cells

Zinc-dependent deacetylase (HDAC) inhibitors with different ZBG groups

(2019) Yan Li et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs

(2019) Giulia Dell’Omo et al.   BRITISH JOURNAL OF CANCER

miRDB: an online database for prediction of functional microRNA targets

(2019) Yuhao Chen et al.   NUCLEIC ACIDS RESEARCH

Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma

(2019) Sangchul Kim et al.   Biomolecules

Defining Driver DNA Methylation Changes in Human Cancer

(2018) Gerd Pfeifer   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromatin conformation regulates the coordination between DNA replication and transcription

(2018) Ricardo Almeida et al.   Nature Communications

Curcumin Attenuates Pulmonary Inflammation in Lipopolysaccharide Induced Acute Lung Injury in Neonatal Rat Model by Activating Peroxisome Proliferator-Activated Receptor γ (PPARγ) Pathway

(2018) Keping Cheng et al.   MEDICAL SCIENCE MONITOR

KDM5 histone demethylases repress immune response via suppression of STING

(2018) Lizhen Wu et al.   PLOS BIOLOGY

The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer

(2018) Seon‑Kyu Kim et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The nasal methylome and childhood atopic asthma

(2017) Ivana V. Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CCAAT/enhancer-binding protein β overexpression alleviates myocardial remodelling by regulating angiotensin-converting enzyme-2 expression in diabetes

(2017) Yuanyuan Tie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

(2017) Cedric R. Clapier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC

(2017) Jea-Woon Ryu et al.   Oncotarget

Oncogenic histone methyltransferase EZH2: A novel prognostic marker with therapeutic potential in endometrial cancer

(2017) Shinya Oki et al.   Oncotarget

Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy

(2016) Ryuji Hamamoto et al.   CANCER SCIENCE

Contribution of MicroRNAs to autoimmune diseases

(2016) Lucien P. Garo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A core viral protein binds host nucleosomes to sequester immune danger signals

(2016) Daphne C. Avgousti et al.   NATURE

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Histone Modifications and Cancer

(2016) James E. Audia et al.   Cold Spring Harbor Perspectives in Biology

HDACs and HDAC Inhibitors in Cancer Development and Therapy

(2016) Yixuan Li et al.   Cold Spring Harbor Perspectives in Medicine

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications

(2015) Kulbhushan Tikoo et al.   BIOCHEMICAL PHARMACOLOGY

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

(2015) Alain Pacis et al.   GENOME RESEARCH

MicroRNAs in cardiovascular disease: an introduction for clinicians

(2015) Simon P R Romaine et al.   HEART

Curcumin attenuated acute Propionibacterium acnes -induced liver injury through inhibition of HMGB1 expression in mice

(2015) Qiaoli Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Precision Medicine Initiative

(2015) Euan A. Ashley   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus

(2015) Chang Liu et al.   JOURNAL OF VIROLOGY

Regulation of circRNA biogenesis

(2015) Ling-Ling Chen et al.   RNA Biology

PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

(2015) Makoto Nakakido et al.   Oncotarget

The Oncogenic Polycomb Histone Methyltransferase EZH2Methylates Lysine 120 on Histone H2B and Competes Ubiquitination

(2015) Masaharu Kogure et al.   NEOPLASIA

WHSC1 Promotes Oncogenesis through Regulation of NIMA-Related Kinase-7 in Squamous Cell Carcinoma of the Head and Neck

(2014) Vassiliki Saloura et al.   MOLECULAR CANCER RESEARCH

Histone demethylase KDM5B is a key regulator of genome stability

(2014) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

(2014) Kenbun Sone et al.   Nature Communications

The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs

(2013) Kim Brint Pedersen et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Intracellular Cargo Receptor ERGIC-53 Is Required for the Production of Infectious Arenavirus, Coronavirus, and Filovirus Particles

(2013) Joseph P. Klaus et al.   Cell Host & Microbe

Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress

(2013) Nicola E. Clarke et al.   CLINICAL SCIENCE

Hepatitis Virus Infection Affects DNA Methylation in Mice With Humanized Livers

(2013) Yasuyuki Okamoto et al.   GASTROENTEROLOGY

Dynamic CCAAT/Enhancer Binding Protein–Associated Changes of DNA Methylation in the Angiotensinogen Gene

(2013) Fen Wang et al.   HYPERTENSION

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice

(2012) Chao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Substantial Histone Reduction Modulates Genomewide Nucleosomal Occupancy and Global Transcriptional Output

(2011) Barbara Celona et al.   PLOS BIOLOGY

Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers

(2010) Masanori Yoshimatsu et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

(2010) Shinya Hayami et al.   INTERNATIONAL JOURNAL OF CANCER

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2

(2010) S. Matsuyama et al.   JOURNAL OF VIROLOGY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem Cells

(2009) Bibekanand Mallick et al.   PLoS One

Lipid rafts are involved in SARS-CoV entry into Vero E6 cells

(2008) Yanning Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

(2008) Hongliang Wang et al.   CELL RESEARCH

SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum

(2008) Kèvin Knoops et al.   PLOS BIOLOGY