Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues

(2020) Emmanuelle Havis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment

(2020) Steven Kregel et al.   NEOPLASIA

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532)

(2020) M. Montopoli et al.   ANNALS OF ONCOLOGY

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Next-generation RNA Sequencing–based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms

(2020) Stephanie L. Skala et al.   EUROPEAN UROLOGY

Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes

(2020) Kausik K. Ray et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regenerative potential of prostate luminal cells revealed by single-cell analysis

(2020) Wouter R. Karthaus et al.   SCIENCE

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

(2020) Konrad H. Stopsack et al.   Cancer Discovery

Impact of sex and gender on COVID-19 outcomes in Europe

(2020) Catherine Gebhard et al.   Biology of Sex Differences

Estradiol, progesterone, immunomodulation and COVID-19 outcomes

(2020) Franck Mauvais-Jarvis et al.   ENDOCRINOLOGY

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer

(2020) Dimple Chakravarty et al.   Communications Biology

Anti‐androgens may protect against severe COVID‐19 outcomes: results from a prospective cohort study of 77 hospitalized men

(2020) A. Goren et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Androgen Deprivation Therapy in Men With Prostate Cancer Does Not Affect Risk of Infection With SARS-CoV-2

(2020) Eric A. Klein et al.   JOURNAL OF UROLOGY

Underlying respiratory diseases, specifically COPD, and smoking are associated with severe COVID-19 outcomes: A systematic review and meta-analysis

(2020) Diana C. Sanchez-Ramirez et al.   RESPIRATORY MEDICINE

Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis

(2020) Stephanie L. Harrison et al.   PLOS MEDICINE

COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2

(2020) Anshumali Mittal et al.   PLoS Pathogens

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Modulation of sialic acid dependence influences the CNS transduction profile of adeno-associated viruses

(2019) Blake H. Albright et al.   JOURNAL OF VIROLOGY

Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration Resistant Prostate Cancer

(2019) Steven Kregel et al.   CLINICAL CANCER RESEARCH

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer

(2019) Abhijit Parolia et al.   NATURE

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production

(2019) Hunter R. Gibbons et al.   Scientific Reports

Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer

(2019) Meghan A. Rice et al.   Frontiers in Oncology

Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging

(2019) Jacob C. Kimmel et al.   GENOME RESEARCH

Single-cell connectomic analysis of adult mammalian lungs

(2019) Micha Sam Brickman Raredon et al.   Science Advances

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

VSTM2A Overexpression Is a Sensitive and Specific Biomarker for Mucinous Tubular and Spindle Cell Carcinoma (MTSCC) of the Kidney

(2018) Lisha Wang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra

(2018) Gervaise H. Henry et al.   Cell Reports

BET Proteins as Targets for Anticancer Treatment

(2017) Anastasios Stathis et al.   Cancer Discovery

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

Suppressive effects of androgens on the immune system

(2015) Abhishek Trigunaite et al.   CELLULAR IMMUNOLOGY

TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice

(2014) C. Tarnow et al.   JOURNAL OF VIROLOGY

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis

(2014) J. M. Lucas et al.   Cancer Discovery

Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice

(2013) Bastian Hatesuer et al.   PLoS Pathogens

Multiobjective evolutionary algorithms to identify highly autocorrelated areas: the case of spatial distribution in financially compromised farms

(2011) Carlos R. García-Alonso et al.   ANNALS OF OPERATIONS RESEARCH