The Role of Protein Disorder in Nuclear Transport and in Its Subversion by Viruses

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

(2020) Sundy N.Y. Yang et al.   ANTIVIRAL RESEARCH

Nipah shell disorder, modes of infection, and virulence

(2020) Gerard Kian-Meng Goh et al.   MICROBIAL PATHOGENESIS

The Nuclear Pore Complex: A Target for NS3 Protease of Dengue and Zika Viruses

(2020) Luis Adrián De Jesús-González et al.   Viruses-Basel

Ivermectin Inhibits Bovine Herpesvirus 1 DNA Polymerase Nuclear Import and Interferes With Viral Replication

(2020) Sohail Raza et al.   Microorganisms

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Shell disorder analysis suggests that pangolins offered a window for a silent spread of an attenuated SARS-CoV-2 precursor among humans

(2020) Gerard Kian-Meng Goh et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of human adenovirus replication by the importin α/β1 nuclear import inhibitor ivermectin

(2020) Cason R. King et al.   JOURNAL OF VIROLOGY

Piggybacking on Classical Import and Other Non-Classical Mechanisms of Nuclear Import Appear Highly Prevalent within the Human Proteome

(2020) Tanner M. Tessier et al.   Biology-Basel

The Effect of FG-Nup Phosphorylation on NPC Selectivity: A One-Bead-Per-Amino-Acid Molecular Dynamics Study

(2019) Ankur Mishra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lack of efficacy of Ivermectin for prevention of a lethal Zika virus infection in a murine system

(2019) Harshada Ketkar et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability

(2019) Bhargavi Jayaraman et al.   Scientific Reports

DisProt: intrinsic protein disorder annotation in 2020

(2019) András Hatos et al.   NUCLEIC ACIDS RESEARCH

Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating

(2019) Juliette Fernandez et al.   Nature Microbiology

Zika and Flavivirus Shell Disorder: Virulence and Fetal Morbidity

(2019) Goh et al.   Biomolecules

How Do Intrinsically Disordered Viral Proteins Hijack the Cell?

(2018) H. Jane Dyson et al.   BIOCHEMISTRY

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting

(2018) Kate M. Smith et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein Regulation by Intrinsically Disordered Regions: A Role for Subdomains in the IDR of the HIV-1 Rev Protein

(2018) Ofrah Faust et al.   CHEMBIOCHEM

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V

(2018) Sarah C. Atkinson et al.   Scientific Reports

Human Rhinovirus 3C protease cleaves RIPK1, concurrent with caspase 8 activation

(2018) Sarah N. Croft et al.   Scientific Reports

Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo

(2018) Changjie Lv et al.   ANTIVIRAL RESEARCH

Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p

(2017) Masako Koyama et al.   GENES TO CELLS

Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights

(2017) Sirawit Ittisoponpisan et al.   HUMAN MUTATION

Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals

(2017) Ho Yee Joyce Fung et al.   eLife

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

Nucleocytoplasmic trafficking of Nipah virus W protein involves multiple discrete interactions with the nuclear import and export machinery

(2016) Michelle D. Audsley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection

(2016) Nicholas J. Barrows et al.   Cell Host & Microbe

Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies

(2016) Sarah L. Shammas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simple rules for passive diffusion through the nuclear pore complex

(2016) Benjamin L. Timney et al.   JOURNAL OF CELL BIOLOGY

Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export

(2016) Ryan T. Behrens et al.   JOURNAL OF VIROLOGY

KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells

(2016) J Etchin et al.   LEUKEMIA

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

(2016) Z A Hing et al.   LEUKEMIA

Correlating Flavivirus virulence and levels of intrinsic disorder in shell proteins: protective roles vs. immune evasion

(2016) Gerard Kian-Meng Goh et al.   Molecular BioSystems

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

(2016) Barak Raveh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling

(2016) Yuki Shindo et al.   Nature Communications

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

(2016) Laura Berneking et al.   PLoS Pathogens

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

(2016) Veronika Götz et al.   Scientific Reports

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

(2015) Friederike K. Kosyna et al.   BIOLOGICAL CHEMISTRY

Visualizing the Molecular Recognition Trajectory of an Intrinsically Disordered Protein Using Multinuclear Relaxation Dispersion NMR

(2015) Robert Schneider et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2Apro

(2015) Nogi Park et al.   JOURNAL OF VIROLOGY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Three cardiovirus Leader proteins equivalently inhibit four different nucleocytoplasmic trafficking pathways

(2015) Jessica J. Ciomperlik et al.   VIROLOGY

Discovery of Small Molecules that Inhibit the Disordered Protein, p27 Kip1

(2015) Luigi I. Iconaru et al.   Scientific Reports

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export

(2015) Sarah A. Port et al.   Cell Reports

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

(2015) Loren E Hough et al.   eLife

A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection

(2014) Johanna E. Fraser et al.   JOURNAL OF INFECTIOUS DISEASES

Nuclear Import of Adenovirus DNA Involves Direct Interaction of Hexon with an N-Terminal Domain of the Nucleoporin Nup214

(2014) Aurélia Cassany et al.   JOURNAL OF VIROLOGY

Functional Characterization of Nuclear Localization and Export Signals in Hepatitis C Virus Proteins and Their Role in the Membranous Web

(2014) Aviad Levin et al.   PLoS One

Structural Mechanism of Nuclear Transport Mediated by Importin β and Flexible Amphiphilic Proteins

(2014) Shige H. Yoshimura et al.   STRUCTURE

Biological Significance of the Importin-β Family-Dependent Nucleocytoplasmic Transport Pathways

(2014) Makoto Kimura et al.   TRAFFIC

Structural Insights into How Yrb2p Accelerates the Assembly of the Xpo1p Nuclear Export Complex

(2014) Masako Koyama et al.   Cell Reports

Nuclear localization of dengue virus (DENV) 1–4 non-structural protein 5; protection against all 4 DENV serotypes by the inhibitor Ivermectin

(2013) M.Y.F. Tay et al.   ANTIVIRAL RESEARCH

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication

(2013) Lindsay Lundberg et al.   ANTIVIRAL RESEARCH

The Arginine-Rich RNA-Binding Motif of HIV-1 Rev Is Intrinsically Disordered and Folds upon RRE Binding

(2013) Fabio Casu et al.   BIOPHYSICAL JOURNAL

Structural basis for cooperativity of CRM1 export complex formation

(2013) T. Monecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1

(2013) Qingxiang Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Determinants and Mechanism of Mammalian CRM1 Allostery

(2013) Nicole Dölker et al.   STRUCTURE

Viral Subversion of Nucleocytoplasmic Trafficking

(2013) Melanie L. Yarbrough et al.   TRAFFIC

Viral Subversion of the Nuclear Pore Complex

(2013) Valerie Le Sage et al.   Viruses-Basel

Hepatitis C Virus-Induced Cytoplasmic Organelles Use the Nuclear Transport Machinery to Establish an Environment Conducive to Virus Replication

(2013) Christopher J. Neufeldt et al.   PLoS Pathogens

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

(2012) Kylie M. Wagstaff et al.   BIOCHEMICAL JOURNAL

HSF Transcription Factor Family, Heat Shock Response, and Protein Intrinsic Disorder

(2012) Sandy D. Westerheide et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

(2012) E. Mastrangelo et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins

(2012) S. Huang et al.   JOURNAL OF VIROLOGY

Sequence and structural analyses of nuclear export signals in the NESdb database

(2012) Darui Xu et al.   MOLECULAR BIOLOGY OF THE CELL

NESdb: a database of NES-containing CRM1 cargoes

(2012) Darui Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-α

(2012) Mary Marfori et al.   TRAFFIC

The Nucleocapsid Protein of Potato Yellow dwarf Virus: Protein Interactions and Nuclear Import Mediated by a Non-Canonical Nuclear Localization Signal

(2012) Gavin Anderson et al.   Frontiers in Plant Science

Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β

(2011) Jonathan F. Soderholm et al.   ACS Chemical Biology

Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection

(2011) Sten Strunze et al.   Cell Host & Microbe

Electrostatic Interactions Involving the Extreme C Terminus of Nuclear Export Factor CRM1 Modulate Its Affinity for Cargo

(2011) Abigail M. Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measles Virus C Protein Interferes with Beta Interferon Transcription in the Nucleus

(2011) K. M. J. Sparrer et al.   JOURNAL OF VIROLOGY

Differential Processing of Nuclear Pore Complex Proteins by Rhinovirus 2A Proteases from Different Species and Serotypes

(2011) K. Watters et al.   JOURNAL OF VIROLOGY

Prediction of leucine-rich nuclear export signal containing proteins with NESsential

(2011) Szu-Chin Fu et al.   NUCLEIC ACIDS RESEARCH

Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: Novel insights into the regulation of Rev nuclear import

(2011) Lili Gu et al.   Retrovirology

Prevalence and Risk Factors for Encephalomyocarditis Virus Infection in Peru

(2011) Josephine Czechowicz et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

(2010) Martin Hintersteiner et al.   ACS Chemical Biology

Conformational Selection in the Recognition of the Snurportin Importin β Binding Domain by Importin β

(2010) Anshul Bhardwaj et al.   BIOCHEMISTRY

How viruses access the nucleus

(2010) Sarah Cohen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

(2010) Masako Koyama et al.   EMBO JOURNAL

Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease

(2010) Nogi Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The RelA Nuclear Localization Signal Folds upon Binding to IκBα

(2010) Carla F. Cervantes et al.   JOURNAL OF MOLECULAR BIOLOGY

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for cooperative RNA binding and export complex assembly by HIV Rev

(2010) Matthew D Daugherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV Rev response element (RRE) directs assembly of the Rev homooligomer into discrete asymmetric complexes

(2010) Matthew D. Daugherty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implications of the HIV-1 Rev dimer structure at 3.2 A resolution for multimeric binding to the Rev response element

(2010) M. A. DiMattia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Oct-3 POU-homeodomain in solution, as determined by triple resonance heteronuclear multidimensional NMR spectroscopy

(2010) Eugene H. Morita et al.   PROTEIN SCIENCE

Quantitative Structural Analysis of Importin-β Flexibility: Paradigm for Solenoid Protein Structures

(2010) Jade K. Forwood et al.   STRUCTURE

Predicting intrinsic disorder in proteins: an overview

(2009) Bo He et al.   CELL RESEARCH

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties

(2009) Steffen Frey et al.   EMBO JOURNAL

Characterisation of the passive permeability barrier of nuclear pore complexes

(2009) Dagmar Mohr et al.   EMBO JOURNAL

Multimerization and DNA Binding Properties of INI1/hSNF5 and Its Functional Significance

(2009) Supratik Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear pore component Nup358 promotes transportin-dependent nuclear import

(2009) S. Hutten et al.   JOURNAL OF CELL SCIENCE

RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage

(2009) A. Castello et al.   JOURNAL OF CELL SCIENCE

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhinovirus 3C Protease Can Localize in the Nucleus and Alter Active and Passive Nucleocytoplasmic Transport

(2009) R. Ghildyal et al.   JOURNAL OF VIROLOGY

Mengovirus-Induced Rearrangement of the Nuclear Pore Complex: Hijacking Cellular Phosphorylation Machinery

(2009) M. V. Bardina et al.   JOURNAL OF VIROLOGY

The Respiratory Syncytial Virus Matrix Protein Possesses a Crm1-Mediated Nuclear Export Mechanism

(2009) R. Ghildyal et al.   JOURNAL OF VIROLOGY

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Protein intrinsic disorder and influenza virulence: the 1918 H1N1 and H5N1 viruses

(2009) Gerard Goh et al.   Virology Journal

Structure and dynamics of the N-terminal half of hepatitis C virus core protein: An intrinsically unstructured protein

(2008) Jean-Baptiste Duvignaud et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of Cell Division by Intrinsically Unstructured Proteins: Intrinsic Flexibility, Modularity, and Signaling Conduits†

(2008) Charles A. Galea et al.   BIOCHEMISTRY

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY

Leader-Induced Phosphorylation of Nucleoporins Correlates with Nuclear Trafficking Inhibition by Cardioviruses

(2008) F. W. Porter et al.   JOURNAL OF VIROLOGY

Importin-β: Structural and Dynamic Determinants of a Molecular Spring

(2008) Ulrich Zachariae et al.   STRUCTURE