Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection
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Title
Critical Roles of N6-Methyladenosine (m6A) in Cancer and Virus Infection
Authors
Keywords
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Journal
Biomolecules
Volume 10, Issue 7, Pages 1071
Publisher
MDPI AG
Online
2020-07-20
DOI
10.3390/biom10071071
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Note: Only part of the references are listed.- METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export
- (2020) Di Li et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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- (2020) Mijia Lu et al. Nature Microbiology
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- (2020) Lei Zhou et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2020) Huilin Huang et al. CANCER CELL
- The Architecture of SARS-CoV-2 Transcriptome
- (2020) Dongwan Kim et al. CELL
- Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms
- (2020) Xi Jin et al. GUT
- Epitranscriptomics in liver disease: Basic concepts and therapeutic potential
- (2020) Zhicong Zhao et al. JOURNAL OF HEPATOLOGY
- m6A-dependent glycolysis enhances colorectal cancer progression
- (2020) Chaoqin Shen et al. Molecular Cancer
- The YTH Domain Family of N6-Methyladenosine “Readers” in the Diagnosis and Prognosis of Colonic Adenocarcinoma
- (2020) Dian Xu et al. Biomed Research International
- The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
- (2019) Maosheng Cheng et al. ONCOGENE
- Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
- (2019) Simona Selberg et al. Cell Reports
- Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
- (2019) Jasmin Paris et al. Cell Stem Cell
- Charging the code — tRNA modification complexes
- (2019) Rościsław Krutyhołowa et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation
- (2019) Luca Pandolfini et al. MOLECULAR CELL
- RNA modifications regulating cell fate in cancer
- (2019) Sylvain Delaunay et al. NATURE CELL BIOLOGY
- The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway
- (2019) Dongkui Gong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
- (2019) Jie Han et al. Molecular Cancer
- METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
- (2019) Ting Li et al. Molecular Cancer
- Effect of methylation of adenine N6 on kink turn structure depends on location
- (2019) Saira Ashraf et al. RNA Biology
- The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1
- (2019) Wujun Miao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
- (2019) Wen Peng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
- (2019) Yunhao Chen et al. Molecular Cancer
- The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasion
- (2019) Tianfang Xia et al. PATHOLOGY RESEARCH AND PRACTICE
- N6-methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication
- (2019) Yang Liu et al. SCIENCE
- The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing
- (2019) Hayley J. Luxton et al. Cancers
- METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
- (2019) Qiang Wang et al. GUT
- METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
- (2019) Ben Yue et al. Molecular Cancer
- METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
- (2019) Xiaoxiang Chen et al. MOLECULAR THERAPY
- Chemical inhibitors make their RNA epigenetic mark
- (2019) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- Association of N6-methyladenosine with viruses and related diseases
- (2019) Fang Wu et al. Virology Journal
- Accurate detection of m6A RNA modifications in native RNA sequences
- (2019) Huanle Liu et al. Nature Communications
- m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
- (2019) Yuanhui Mao et al. Nature Communications
- Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma
- (2019) Sangchul Kim et al. Biomolecules
- IGF2BP2 regulates DANCR by serving as an N6-methyladenosine reader
- (2019) Xiaoge Hu et al. CELL DEATH AND DIFFERENTIATION
- Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection
- (2019) Nandan S. Gokhale et al. MOLECULAR CELL
- m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression
- (2018) Jiqin Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling
- (2018) Rui Su et al. CELL
- Modifications and functional genomics of human transfer RNA
- (2018) Tao Pan CELL RESEARCH
- METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m 6 A Modification
- (2018) Hengyou Weng et al. Cell Stem Cell
- ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation
- (2018) Yuan He et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Regulation of poly ADP-Ribose polymerase 1 functions by post-translational modifications
- (2018) Ryuji Hamamoto Frontiers in Bioscience-Landmark
- Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d
- (2018) Philip Knuckles et al. GENES & DEVELOPMENT
- RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
- (2018) Mengnuo Chen et al. HEPATOLOGY
- Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
- (2018) Huilin Huang et al. NATURE CELL BIOLOGY
- Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
- (2018) Seth D. Kasowitz et al. PLoS Genetics
- N 6 -methyladenosine modification: a novel pharmacological target for anti-cancer drug development
- (2018) Yi Niu et al. Acta Pharmaceutica Sinica B
- VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
- (2018) Yanan Yue et al. Cell Discovery
- The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
- (2018) Alessandro Bertero et al. NATURE
- mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
- (2018) Junho Choe et al. NATURE
- m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
- (2018) Jun Liu et al. NATURE CELL BIOLOGY
- Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis
- (2018) Takaaki Taniguchi et al. Nature Chemical Biology
- Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma
- (2018) Yoshinobu Shigekawa et al. Oncotarget
- Structural insights into the RNA methyltransferase domain of METTL16
- (2018) Agnieszka Ruszkowska et al. Scientific Reports
- The m6A-methylase complex recruits TREX and regulates mRNA export
- (2018) Simon Lesbirel et al. Scientific Reports
- The novel prognostic marker, EHMT2, is involved in cell proliferation via HSPD1 regulation in breast cancer
- (2018) Seon‑Kyu Kim et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent manner
- (2018) Simon Müller et al. NUCLEIC ACIDS RESEARCH
- YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
- (2018) Li Zhong et al. CANCER LETTERS
- The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells
- (2017) Kosuke Taketo et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Three distinct 3-methylcytidine (m 3 C) methyltransferases modify tRNA and mRNA in mice and humans
- (2017) Luang Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of m 6 A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
- (2017) Magdalena Natalia Wojtas et al. MOLECULAR CELL
- m 6 A Facilitates eIF4F-Independent mRNA Translation
- (2017) Ryan A. Coots et al. MOLECULAR CELL
- Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
- (2017) Isaia Barbieri et al. NATURE
- The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
- (2017) Ly P Vu et al. NATURE MEDICINE
- RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding
- (2017) Philip Knuckles et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Identification of factors required for m6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
- (2017) Kamil Růžička et al. NEW PHYTOLOGIST
- N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
- (2017) Marek Bartosovic et al. NUCLEIC ACIDS RESEARCH
- Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
- (2017) A Visvanathan et al. ONCOGENE
- Frameshift Mutations in Repeat Sequences of ANK3, HACD4, TCP10L, TP53BP1, MFN1, LCMT2, RNMT, TRMT6, METTL8 and METTL16 Genes in Colon Cancers
- (2017) Su Yeon Yeon et al. PATHOLOGY & ONCOLOGY RESEARCH
- Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs
- (2017) Rakesh David et al. PLANT CELL
- ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
- (2017) Chong Tang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The RNA modification landscape in human disease
- (2017) Nicky Jonkhout et al. RNA
- RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding
- (2017) Philip Knuckles et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC
- (2017) Jea-Woon Ryu et al. Oncotarget
- Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
- (2017) Yujiro Nishizawa et al. Oncotarget
- S -Adenosylmethionine Synthesis Is Regulated by Selective N 6 -Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1
- (2017) Hiroki Shima et al. Cell Reports
- m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells
- (2017) Qi Cui et al. Cell Reports
- 60 years ago, Francis Crick changed the logic of biology
- (2017) Matthew Cobb PLOS BIOLOGY
- YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
- (2017) Ian A Roundtree et al. eLife
- RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated
- (2016) Atsushi Tanabe et al. CANCER LETTERS
- Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy
- (2016) Ryuji Hamamoto et al. CANCER SCIENCE
- Dynamics of Human and Viral RNA Methylation during Zika Virus Infection
- (2016) Gianluigi Lichinchi et al. Cell Host & Microbe
- N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
- (2016) Nandan S. Gokhale et al. Cell Host & Microbe
- Posttranscriptional m 6 A Editing of HIV-1 mRNAs Enhances Viral Gene Expression
- (2016) Edward M. Kennedy et al. Cell Host & Microbe
- METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulatingN6-methyladenosine-dependent primary MicroRNA processing
- (2016) Jin-zhao Ma et al. HEPATOLOGY
- Nuclear m 6 A Reader YTHDC1 Regulates mRNA Splicing
- (2016) Wen Xiao et al. MOLECULAR CELL
- The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
- (2016) Shuibin Lin et al. MOLECULAR CELL
- m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
- (2016) Irmgard U. Haussmann et al. NATURE
- The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
- (2016) Dan Dominissini et al. NATURE
- m6A RNA methylation promotes XIST-mediated transcriptional repression
- (2016) Deepak P. Patil et al. NATURE
- Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome
- (2016) Xiaoyu Li et al. Nature Chemical Biology
- Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
- (2016) Chuanzhao Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
- (2016) Hao Du et al. Nature Communications
- N6-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression
- (2016) Nagaraja Tirumuru et al. eLife
- Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
- (2016) Gianluigi Lichinchi et al. Nature Microbiology
- N6-methyladenosine Modulates Messenger RNA Translation Efficiency
- (2015) Xiao Wang et al. CELL
- m6A RNA Methylation Is Regulated by MicroRNAs and Promotes Reprogramming to Pluripotency
- (2015) Tong Chen et al. Cell Stem Cell
- Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
- (2015) Francesca Aguilo et al. Cell Stem Cell
- Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
- (2015) Caroline Roost et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural imprints in vivo decode RNA regulatory mechanisms
- (2015) Robert C. Spitale et al. NATURE
- N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
- (2015) Nian Liu et al. NATURE
- Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly
- (2015) Yury S Polikanov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Control of Chromatin Structure by Long Noncoding RNA
- (2015) Gudrun Böhmdorfer et al. TRENDS IN CELL BIOLOGY
- The NSD family of protein methyltransferases in human cancer
- (2015) Theodore Vougiouklakis et al. Epigenomics
- Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly
- (2015) Yury S Polikanov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway
- (2015) Gouji Toyokawa et al. NEOPLASIA
- The Oncogenic Polycomb Histone Methyltransferase EZH2Methylates Lysine 120 on Histone H2B and Competes Ubiquitination
- (2015) Masaharu Kogure et al. NEOPLASIA
- FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
- (2014) Xu Zhao et al. CELL RESEARCH
- Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
- (2014) Xiao-Li Ping et al. CELL RESEARCH
- Dynamic RNA Modifications in Posttranscriptional Regulation
- (2014) Xiao Wang et al. MOLECULAR CELL
- N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells
- (2014) Yang Wang et al. NATURE CELL BIOLOGY
- Role of tRNA modifications in human diseases
- (2014) Adrian Gabriel Torres et al. TRENDS IN MOLECULAR MEDICINE
- Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair
- (2014) Kenbun Sone et al. Nature Communications
- Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
- (2014) Schraga Schwartz et al. Cell Reports
- Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism
- (2014) Scott C. Farrow et al. Frontiers in Plant Science
- RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
- (2013) Jean-Michel Fustin et al. CELL
- Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle
- (2013) Keiko Horiuchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- N6-methyladenosine-dependent regulation of messenger RNA stability
- (2013) Xiao Wang et al. NATURE
- A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
- (2013) Jianzhao Liu et al. Nature Chemical Biology
- Expression and roles of Wilms' tumor 1-associating protein in glioblastoma
- (2012) Du-Il Jin et al. CANCER SCIENCE
- Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
- (2012) Kate D. Meyer et al. CELL
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
- (2012) Dan Dominissini et al. NATURE
- Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
- (2012) Hyun-Soo Cho et al. Nature Communications
- The Histone Demethylase JMJD2B Plays an Essential Role in Human Carcinogenesis through Positive Regulation of Cyclin-Dependent Kinase 6
- (2011) G. Toyokawa et al. Cancer Prevention Research
- Inhibition of 2-oxoglutarate dependent oxygenases
- (2011) Nathan R. Rose et al. CHEMICAL SOCIETY REVIEWS
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers
- (2010) Shinya Hayami et al. INTERNATIONAL JOURNAL OF CANCER
- The YTH Domain Is a Novel RNA Binding Domain
- (2010) Zhaiyi Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The spike protein of SARS-CoV — a target for vaccine and therapeutic development
- (2009) Lanying Du et al. NATURE REVIEWS MICROBIOLOGY
- Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression
- (2008) S. S. Hebert et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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