Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Activation and Inhibition of the NLRP3 Inflammasome by RNA Viruses

(2021) SK Mohiuddin Choudhury et al.   Journal of Inflammation Research

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers

(2020) Alexander Hedbrant et al.   MEDIATORS OF INFLAMMATION

Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay

(2020) Huan Chen et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effects of NIX‐mediated mitophagy on ox‐LDL‐induced macrophage pyroptosis in atherosclerosis

(2020) Xue Peng et al.   CELL BIOLOGY INTERNATIONAL

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells

(2020) Mi Wang et al.   JOURNAL OF ANATOMY

Hydrogen Sulfide Therapy Suppresses Cofilin-2 and Attenuates Ischemic Heart Failure in a Mouse Model of Myocardial Infarction

(2020) Khoa Nguyen et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death

(2020) Rajendra Karki et al.   JOURNAL OF IMMUNOLOGY

Treatment options for COVID-19: The reality and challenges

(2020) Shio-Shin Jean et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Electroacupuncture preconditioning attenuates acute myocardial ischemia injury through inhibiting NLRP3 inflammasome activation in mice

(2020) Tao Zhang et al.   LIFE SCIENCES

Kawasaki disease: pathophysiology and insights from mouse models

(2020) Magali Noval Rivas et al.   Nature Reviews Rheumatology

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

(2020) Hayley I. Muendlein et al.   SCIENCE

Visfatin/eNampt induces endothelial dysfunction in vivo: a role for Toll-Like Receptor 4 and NLRP3 inflammasome

(2020) Tania Romacho et al.   Scientific Reports

Chemerin/CMKLR1 Axis Promotes Inflammation and Pyroptosis by Activating NLRP3 Inflammasome in Diabetic Cardiomyopathy Rat

(2020) Yebin Xie et al.   Frontiers in Physiology

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches

(2020) F. Moccia et al.   GeroScience

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

(2020) Marie Pouletty et al.   ANNALS OF THE RHEUMATIC DISEASES

Discovery of novel TNNI3K inhibitor suppresses pyroptosis and apoptosis in murine myocardial infarction injury

(2020) Haiying Pang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

(2020) Zhonghua Liu et al.   IMMUNITY

MLKL Aggravates Ox-LDL-Induced Cell Pyroptosis via Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells

(2020) Qian Wu et al.   INFLAMMATION

Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens?

(2020) Maria Dalamaga et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Artemisinin suppresses myocardial ischemia–reperfusion injury via NLRP3 inflammasome mechanism

(2020) Fengyue Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms

(2020) Michal P. Wandel et al.   NATURE IMMUNOLOGY

Inflammasomes and Cell Death: Common Pathways in Microparticle Diseases

(2020) Maryam Rashidi et al.   TRENDS IN MOLECULAR MEDICINE

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle

(2020) Zhiyuan Li et al.   PLOS BIOLOGY

Mitochondria targeted peptide SS-31 prevent on cisplatin-induced acute kidney injury via regulating mitochondrial ROS-NLRP3 pathway

(2020) Shi-kun Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

ASC-deficiency impairs host defense against Aeromonas hydrophila infection in Japanese medaka, Oryzias latipes

(2020) Natsuki Morimoto et al.   FISH & SHELLFISH IMMUNOLOGY

Distinct clinical and immunological features of SARS–CoV-2–induced multisystem inflammatory syndrome in children

(2020) Pui Y. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection

(2020) A. Klimke et al.   MEDICAL HYPOTHESES

Cholesterol Crystals and NLRP3 Mediated Inflammation in the Uterine Wall Decidua in Normal and Preeclamptic Pregnancies

(2020) Gabriela Brettas Silva et al.   Frontiers in Immunology

Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

(2020) Nathalie Niyonzima et al.   EBioMedicine

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

(2019) Rhiannon I. Campden et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

P2Y2R activation by ATP induces oxLDL-mediated inflammasome activation through modulation of mitochondrial damage in human endothelial cells

(2019) Hana Jin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

(2019) Tao Zhuang et al.   CIRCULATION RESEARCH

Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway

(2019) Yang-Shuo Tang et al.   INFLAMMATION RESEARCH

The role of Caspase 1 in ischemia/reperfusion injury of the myocardium.

(2019) Ali Rauf et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy

(2019) Negin Parsamanesh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective role of p120‐catenin on mitochondria by inhibiting NLRP3 in ventilator‐induced lung injury

(2019) Ge Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

(2019) Yang Long et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells

(2019) Kishino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation

(2019) Chang Jia et al.   Cell Death & Disease

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease

(2019) Fumiya Anzai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Bnip3 mediates doxorubicin-induced cardiomyocyte pyroptosis via caspase-3/GSDME

(2019) Xinbin Zheng et al.   LIFE SCIENCES

LncRNA KLF3-AS1 in human mesenchymal stem cell-derived exosomes ameliorates pyroptosis of cardiomyocytes and myocardial infarction through miR-138-5p/Sirt1 axis

(2019) Qing Mao et al.   Stem Cell Research & Therapy

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE −/− ) mice through reducing inflammation via the suppression of NLRP3 signaling pathway

(2018) Jin Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Caspase-1 regulates Ang II-induced cardiomyocyte hypertrophy via up-regulation of IL-1β

(2018) Yunlong Bai et al.   BIOSCIENCE REPORTS

The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury

(2018) Xintong Ge et al.   BRAIN RESEARCH

Exosomes derived from embryonic stem cells inhibit doxorubicin and inflammation-induced pyroptosis in muscle cells

(2018) Zahra Tavakoli Dargani et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis

(2018) Gantsetseg Tumurkhuu et al.   Cell Metabolism

Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders

(2018) M. Juhani Junttila et al.   CIRCULATION

Preventive effects of astragaloside IV and its active sapogenin cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3 inflammasome

(2018) Yu Wan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Myocardial Interstitial Fibrosis in Heart Failure

(2018) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis

(2018) Xianxian Wu et al.   Cell Death & Disease

Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

(2018) Fan Yang et al.   Cell Death & Disease

Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications

(2018) Gong Chen et al.   Frontiers in Physiology

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

(2018) Shalini M Krishnan et al.   CARDIOVASCULAR RESEARCH

Role of pyroptosis in cardiovascular disease

(2018) Zeng Zhaolin et al.   CELL PROLIFERATION

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Necrosis and necroptosis in germ cell depletion from mammalian ovary

(2018) Govind R. Chaudhary et al.   JOURNAL OF CELLULAR PHYSIOLOGY

What role does pyroptosis play in microbial infection?

(2018) Xiaojing Xia et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long-Term Prognostic Value of Myocardial Fibrosis in Patients With Chagas Cardiomyopathy

(2018) Tiago Senra et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Acinetobacter baumannii outer membrane protein 34 elicits NLRP3 inflammasome activation via mitochondria-derived reactive oxygen species in RAW264.7 macrophages

(2018) Zhiyuan An et al.   MICROBES AND INFECTION

Gasdermin E Does Not Limit Apoptotic Cell Disassembly by Promoting Early Onset of Secondary Necrosis in Jurkat T Cells and THP-1 Monocytes

(2018) Rochelle Tixeira et al.   Frontiers in Immunology

Role of pyroptosis in cardiovascular diseases

(2018) Chang Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Low-dose sinapic acid abates the pyroptosis of macrophages via downregulation of lncRNA-MALAT1 in rats with diabetic atherosclerosis

(2017) Yong Han et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Association of Elevated NT-proBNP With Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

(2017) Chia-Ying Liu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cell-Specific Pathways Supporting Persistent Fibrosis in Heart Failure

(2017) Stephen D. Farris et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension

(2017) Hai-Jian Sun et al.   Cell Death & Disease

New Role for Interleukin‐13 Receptor α1 in Myocardial Homeostasis and Heart Failure

(2017) Uri Amit et al.   Journal of the American Heart Association

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

(2017) Motoi Kobayashi et al.   PLoS One

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Orianne Henri et al.   CIRCULATION

Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents AtherosclerosisNovelty and Significance

(2016) Gantsetseg Tumurkhuu et al.   CIRCULATION RESEARCH

Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture

(2016) Sonomi Maruyama et al.   EMBO Molecular Medicine

Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)

(2016) Neil A. Turner   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Renal toxicity of anticancer agents targeting vascular endothelial growth factor (VEGF) and its receptors (VEGFRs)

(2016) Laura Cosmai et al.   JOURNAL OF NEPHROLOGY

Pheochromocytoma Is Characterized by Catecholamine-Mediated Myocarditis, Focal and Diffuse Myocardial Fibrosis, and Myocardial Dysfunction

(2016) Vanessa M. Ferreira et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells

(2016) H. A. Mena et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

(2016) Gustavo Monnerat et al.   Nature Communications

Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets

(2015) Yow Keat Tham et al.   ARCHIVES OF TOXICOLOGY

Molecular switches under TGFβ signalling during progression from cardiac hypertrophy to heart failure

(2015) J Heger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

(2015) S M Krishnan et al.   BRITISH JOURNAL OF PHARMACOLOGY

NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1

(2015) Jie Qi et al.   Cardiovascular Toxicology

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heart failure duration progressively modulates the arrhythmia substrate through structural and electrical remodeling

(2015) Victor P. Long et al.   LIFE SCIENCES

Overexpression of Caspase-1 in Aorta of Patients with Coronary Atherosclerosis

(2014) Fei Zheng et al.   Heart Lung and Circulation

Interleukin-1β Reduces L-type Ca2+Current through Protein Kinase Cϵ Activation in Mouse Heart

(2014) Nabil El Khoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Mizoribine Ameliorates Renal Injury and Hypertension along with the Attenuation of Renal Caspase-1 Expression in Aldosterone-Salt-Treated Rats

(2014) Toshiki Doi et al.   PLoS One

MicroRNA-30d regulates cardiomyocyte pyroptosis by directly targeting foxo3a in diabetic cardiomyopathy

(2014) X Li et al.   Cell Death & Disease

LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking

(2013) Fengyan Jin et al.   ANGIOGENESIS

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

Biomarkers of heart failure with normal ejection fraction: a systematic review

(2013) Jin M. Cheng et al.   EUROPEAN JOURNAL OF HEART FAILURE

Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease

(2012) Youngho Lee et al.   CIRCULATION

Increased interleukin-1β levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention

(2012) S. Ørn et al.   JOURNAL OF INTERNAL MEDICINE

Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets

(2012) Jianglong Hou et al.   PHARMACOLOGY & THERAPEUTICS

Vasculitis Is an Antiangiogenic State

(2011) I. E. Stillman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation

(2010) L. Yue et al.   CARDIOVASCULAR RESEARCH

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure