MLKL Aggravates Ox-LDL-Induced Cell Pyroptosis via Activation of NLRP3 Inflammasome in Human Umbilical Vein Endothelial Cells

The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling

(2019) Feng-Xia Guo et al.   CELL DEATH AND DIFFERENTIATION

Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A

(2019) Lei Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Caspases in Cell Death, Inflammation, and Disease

(2019) Nina Van Opdenbosch et al.   IMMUNITY

TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL

(2019) Ayaz Najafov et al.   MOLECULAR CELL

MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses

(2019) Qun Zhao et al.   CANCER LETTERS

Oxidized low density lipoproteins: The bridge between atherosclerosis and autoimmunity. Possible implications in accelerated atherosclerosis and for immune intervention in autoimmune rheumatic disorders

(2018) Claudia Floriana Suciu et al.   AUTOIMMUNITY REVIEWS

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism

(2018) Wenjing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

Role of pyroptosis in cardiovascular disease

(2018) Zeng Zhaolin et al.   CELL PROLIFERATION

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D

(2017) Kimberley D. Gutierrez et al.   JOURNAL OF IMMUNOLOGY

Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors

(2017) Leticia Fernández-Friera et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Analysis of necroptotic proteins in failing human hearts

(2017) Adrián Szobi et al.   Journal of Translational Medicine

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyridoxine 5′-phosphate oxidase is a novel therapeutic target and regulated by the TGF-β signalling pathway in epithelial ovarian cancer

(2017) Lingyun Zhang et al.   Cell Death & Disease

The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

(2017) Katharina S. Schneider et al.   Cell Reports

MLKL forms cation channels

(2016) Bingqing Xia et al.   CELL RESEARCH

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

Inflammatory cytokines in atherosclerosis: current therapeutic approaches

(2016) Dimitris Tousoulis et al.   EUROPEAN HEART JOURNAL

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation

(2016) Lei Wang et al.   Oncotarget

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

(2016) Geena Paramel Varghese et al.   Journal of the American Heart Association

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

Coronary Endothelial Dysfunction Induced by Nucleotide Oligomerization Domain-Like Receptor Protein with Pyrin Domain Containing 3 Inflammasome Activation During Hypercholesterolemia: Beyond Inflammation

(2015) Yang Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bone marrow-specific caspase-1/11 deficiency inhibits atherosclerosis development inLdlr−/−mice

(2015) Tim Hendrikx et al.   FEBS Journal

Caspase-1–Independent IL-1 Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules

(2015) Hengameh Sadeghi et al.   JOURNAL OF IMMUNOLOGY

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

(2015) Xin Shi et al.   Journal of Stroke & Cerebrovascular Diseases

Overexpression of Caspase-1 in Aorta of Patients with Coronary Atherosclerosis

(2014) Fei Zheng et al.   Heart Lung and Circulation

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Oxidized Low Density Lipoprotein Induced Caspase-1 Mediated Pyroptotic Cell Death in Macrophages: Implication in Lesion Instability?

(2013) Jing Lin et al.   PLoS One

Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice

(2012) Fumitake Usui et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

(2012) Jessica Gage et al.   CANADIAN JOURNAL OF CARDIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY