IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death

IRF8 Regulates Transcription of Naip s for NLRC4 Inflammasome Activation

(2018) Rajendra Karki et al.   CELL

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses

(2018) Beiyun C. Liu et al.   Cell Reports

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice

(2018) Bhesh Raj Sharma et al.   CELL DEATH AND DIFFERENTIATION

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

(2018) Benoit Briard et al.   Nature Microbiology

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Type I Interferon Signaling Prevents IL-1β-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue

(2016) Virginia Castiglia et al.   Cell Host & Microbe

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

(2015) Rajendra Karki et al.   Cell Host & Microbe

SalmonellaTyphimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively

(2015) Darren J. Perkins et al.   JOURNAL OF IMMUNOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2015) Tobias Steinfeldt et al.   PLOS BIOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

RIOK3 Is an Adaptor Protein Required for IRF3-Mediated Antiviral Type I Interferon Production

(2014) Jun Feng et al.   JOURNAL OF VIROLOGY

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa

(2013) Yash R. Patankar et al.   INFECTION AND IMMUNITY

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense against Enteropathogens

(2012) Prajwal Gurung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

IRF8 and IRF3 cooperatively regulate rapid interferon-  induction in human blood monocytes

(2011) P. Li et al.   BLOOD

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE