Design and evolution of chimeric streptavidin for protein-enabled dual gold catalysis

Systematic engineering of artificial metalloenzymes for new-to-nature reactions

(2021) Tobias Vornholt et al.   Science Advances

Engineering new catalytic activities in enzymes

(2020) Kai Chen et al.   Nature Catalysis

Synergistic catalysis in an artificial enzyme by simultaneous action of two abiological catalytic sites

(2020) Zhi Zhou et al.   Nature Catalysis

Molecular Modeling for Artificial Metalloenzyme Design and Optimization

(2020) Lur Alonso-Cotchico et al.   ACCOUNTS OF CHEMICAL RESEARCH

Beyond the Second Coordination Sphere: Engineering Dirhodium Artificial Metalloenzymes To Enable Protein Control of Transition Metal Catalysis

(2019) Jared C. Lewis   ACCOUNTS OF CHEMICAL RESEARCH

Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Enzymatic Cascades and Directed Evolution

(2019) Alexandria Deliz Liang et al.   ACCOUNTS OF CHEMICAL RESEARCH

LmrR: A Privileged Scaffold for Artificial Metalloenzymes

(2019) Gerard Roelfes   ACCOUNTS OF CHEMICAL RESEARCH

Hemoproteins Reconstituted with Artificial Metal Complexes as Biohybrid Catalysts

(2019) Koji Oohora et al.   ACCOUNTS OF CHEMICAL RESEARCH

De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities

(2019) Angela Lombardi et al.   ACCOUNTS OF CHEMICAL RESEARCH

Site-Selective Functionalization of (sp3)C-H Bonds Catayzed by Artificial Metalloenzymes Containing an Iridium-Porphyrin Cofactor

(2019) Yang Gu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

(2019) Ge Qu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biocompatibility and therapeutic potential of glycosylated albumin artificial metalloenzymes

(2019) Shohei Eda et al.   Nature Catalysis

Golden potential

(2019) Euan B. McLean et al.   Nature Chemistry

Bio-additive-based screening: toward evaluation of the biocompatibility of chemical reactions

(2019) Lea Anhäuser et al.   Nature Protocols

Genetically engineered proteins with two active sites for enhanced biocatalysis and synergistic chemo- and biocatalysis

(2019) Sandra Alonso et al.   Nature Catalysis

Directed Evolution of an Artificial Imine Reductase

(2018) Martina Hestericová et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells

(2018) Cristian Vidal et al.   Nature Communications

Intracellular Deprotection Reactions Mediated by Palladium Complexes Equipped with Designed Phosphine Ligands

(2018) Miguel Martínez-Calvo et al.   ACS Catalysis

A Whole Cell E. coli Display Platform for Artificial Metalloenzymes: Poly(phenylacetylene) Production with a Rhodium–Nitrobindin Metalloprotein

(2018) Alexander R. Grimm et al.   ACS Catalysis

A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme

(2018) Evan N. Mirts et al.   SCIENCE

The Future of Bioorthogonal Chemistry

(2018) Neal K. Devaraj   ACS Central Science

Evolution of a highly active and enantiospecific metalloenzyme from short peptides

(2018) Sabine Studer et al.   SCIENCE

GaudiMM: A modular multi-objective platform for molecular modeling

(2017) Jaime Rodríguez-Guerra Pedregal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology: Challenges and Opportunities

(2016) Tillmann Heinisch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Well-Defined Dinuclear Gold Complexes for Preorganization-Induced Selective Dual Gold Catalysis

(2016) Vincent Vreeken et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold catalysis in total synthesis – recent achievements

(2016) Daniel Pflästerer et al.   CHEMICAL SOCIETY REVIEWS

Directed evolution of artificial metalloenzymes for in vivo metathesis

(2016) Markus Jeschek et al.   NATURE

Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity

(2015) Ruth Dorel et al.   CHEMICAL REVIEWS

Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure

(2015) Marco Chino et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Synthesis and properties of a biotin-tagged NHC–gold complex

(2015) Viola Breker et al.   TETRAHEDRON LETTERS

Neutralizing the Detrimental Effect of Glutathione on Precious Metal Catalysts

(2014) Yvonne M. Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A designed supramolecular protein assembly with in vivo enzymatic activity

(2014) Woon Ju Song et al.   SCIENCE

Computational Insights on an Artificial Imine Reductase Based on the Biotin–Streptavidin Technology

(2014) Victor Muñoz Robles et al.   ACS Catalysis

Biotinylated Metathesis Catalysts: Synthesis and Performance in Ring Closing Metathesis

(2013) Anna Kajetanowicz et al.   CATALYSIS LETTERS

Straightforward synthesis of [Au(NHC)X] (NHC = N-heterocyclic carbene, X = Cl, Br, I) complexes

(2013) Alba Collado et al.   CHEMICAL COMMUNICATIONS

Competitive Gold-Activation Modes in Terminal Alkynes: An Experimental and Mechanistic Study

(2013) Ana Gimeno et al.   CHEMISTRY-A EUROPEAN JOURNAL

A systematic development of a polarizable potential of water

(2013) Péter T. Kiss et al.   JOURNAL OF CHEMICAL PHYSICS

Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines

(2013) Fabien W. Monnard et al.   Chemical Science

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

The Role of Gold Acetylides as a Selectivity Trigger and the Importance of gem-Diaurated Species in the Gold-Catalyzed Hydroarylating-Aromatization of Arene-Diynes

(2012) A. Stephen K. Hashmi et al.   ORGANOMETALLICS

Biotinylated Rh(III) Complexes in Engineered Streptavidin for Accelerated Asymmetric C-H Activation

(2012) T. K. Hyster et al.   SCIENCE

A novel fluorescent probe for Au(iii)/Au(i) ions based on an intramolecular hydroamination of a Bodipy derivative and its application to bioimaging

(2011) Jian-Bo Wang et al.   CHEMICAL COMMUNICATIONS

Experimental and Computational Evidence for Gold Vinylidenes: Generation from Terminal Alkynes via a Bifurcation Pathway and Facile C–H Insertions

(2011) Longwu Ye et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

NHC-Stabilized Gold(I) Complexes: Suitable Catalysts for 6-exo-dig Heterocyclization of 1-(o-Ethynylaryl)ureas

(2010) Ana Gimeno et al.   ORGANIC LETTERS

Thermodynamic and structural consequences of flexible loop deletion by circular permutation in the streptavidin-biotin system

(2010) Vano Chu et al.   PROTEIN SCIENCE

Thiol-Reactive Derivatives of the Solvatochromic 4-N,N-Dimethylamino-1,8-naphthalimide Fluorophore: A Highly Sensitive Toolset for the Detection of Biomolecular Interactions

(2009) Galen Loving et al.   BIOCONJUGATE CHEMISTRY

Highly selective fluorescent probe for Au3+ based on cyclization of propargylamide

(2009) Min Jung Jou et al.   CHEMICAL COMMUNICATIONS

Gold-catalyzed intramolecular hydroamination of terminal alkynes in aqueous media: efficient and regioselective synthesis of indole-1-carboxamides

(2009) Deju Ye et al.   GREEN CHEMISTRY

Universal Solvation Model Based on Solute Electron Density and on a Continuum Model of the Solvent Defined by the Bulk Dielectric Constant and Atomic Surface Tensions

(2009) Aleksandr V. Marenich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Designing artificial enzymes by intuition and computation

(2009) Vikas Nanda et al.   Nature Chemistry

Gold-Catalyzed Cycloisomerization of 1,5-Allenynes via Dual Activation of an Ene Reaction

(2008) Paul Ha-Yeon Cheong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ruthenium-Catalyzed Azide−Alkyne Cycloaddition: Scope and Mechanism

(2008) Brant C. Boren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY