Article
Chemistry, Multidisciplinary
Xian Zhao, Xiaoliang Feng, Fan Chen, Shengqing Zhu, Feng-Ling Qing, Lingling Chu
Summary: A metallaphotoredox-catalyzed strategy for the aminocarbonylation of alkynes with amines and CO has been developed. This method allows for selective synthesis of alpha,beta-unsaturated amides and a sequential four-component hydroaminocarbonylation/radical alkylation, demonstrating great potential in the selective and divergent functionalization of alkynes. Preliminary mechanistic studies suggest a photoinduced oxidative insertion of aniline and CO into nickel followed by a migratory insertion of (carbamoyl)nickel species may be involved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Mathematics, Applied
Xiao-kai Chang, Junfeng Yang, Hongchao Zhang
Summary: The golden ratio primal-dual algorithm (GRPDA) is a new variant of the classical Arrow-Hurwicz method for solving structured convex optimization problems. It allows larger stepsizes and a linesearch strategy is proposed to improve the algorithm. Numerical experiments demonstrate the effectiveness of the proposed linesearch strategy.
SIAM JOURNAL ON OPTIMIZATION
(2022)
Article
Chemistry, Multidisciplinary
Christoph M. Hendrich, Sebastian Senn, Lea Haas, Marvin T. Hoffmann, Ute Zschieschang, Luca C. Greiner, Frank Rominger, Matthias Rudolph, Hagen Klauk, Andreas Dreuw, A. Stephen K. Hashmi
Summary: In this research, a gold-catalyzed cascade cyclization reaction was developed to synthesize new Boc-protected dihydrobenzo[c]phenanthridines, with successful improvements in synthetic methods and applications in organic semiconductor research.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Organic
Xin Ji, Lu Liu
Summary: This Review summarizes the unique chemical properties of organoboron compounds and their specific catalytic activity in organic transformations via the dual catalysis of boron and another catalyst.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Abdoul G. Diallo, Deborah Paris, Djiby Faye, Sylvain Gaillard, Mark Lautens, Jean-Luc Renaud
Summary: This study reports a general approach for the allylation of oxa- and azabenzonorbornadienes by merging organophotoredox and nickel catalysis. The method allows for selective allylation of various heterocyclic alkene derivatives with a broader range of allylic acetate compounds. Notably, the reaction does not require air-sensitive organometallic species or metal reductants.
Article
Chemistry, Organic
Chandi C. Malakar, Luca Dell'Amico, Wanbin Zhang
Summary: Dual catalysis is a powerful strategy for chemical reactions in organic synthesis, with advantages such as increased reactivity, control of stereoselectivity, and stereodivergent synthesis. This Perspective aims to introduce the reader to the special collection on Dual Catalysis in EurJOC, summarizing the different categories of dual catalysis and demonstrating their benefits in constructing new chemical bonds selectively. It also presents current challenges and new trends in dual catalysis.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Engineering, Chemical
Ion Iliuta, Faical Larachi
Summary: Enzyme-mediated direct CO2 hydrogenation coupled with upstream enzyme-mediated direct air capture (DAC) in fixed-bed reactors has been proposed for the bioconversion of atmospheric CO2. Through 3D modeling, the performance of these enzymatic processes was evaluated, revealing that the direct CO2 hydrogenation reactor outperforms the DAC reactor in extracting CO2. However, it is important to remove formate from the reaction system to ensure smooth circulation and CO2 reduction.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Mathematics, Applied
Xiaokai Chang, Junfeng Yang
Summary: The paper introduces a new optimization algorithm, GRPDA, to solve structured convex optimization problems. GRPDA has a broader convergence range compared to the classical PDA and can improve efficiency. An accelerated version of the optimization algorithm can be constructed when either the primal or dual problem is strongly convex.
JOURNAL OF SCIENTIFIC COMPUTING
(2021)
Article
Chemistry, Multidisciplinary
Jiaqing Lu, Yan Yao, Liubo Li, Niankai Fu
Summary: The direct decarboxylative alkenylation of widely available aliphatic carboxylic acids with vinyl halides has been achieved using Ce/Ni dual transition metal electrocatalysis. This reaction allows for the synthesis of alkenes with all substitution patterns and has a broad scope with respect to both coupling partners. The reaction can readily utilize simple primary alkyl carboxylic acids as carbon-centered radical precursors. Mechanistic studies have been conducted to understand the key intermediates and pathway of the reaction using controlled experiments and cyclic voltammetry data.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Francesco Calogero, Giandomenico Magagnano, Simone Potenti, Andrea Gualandi, Andrea Fermi, Paola Ceroni, Pier Giorgio Cozzi
Summary: A regioselective vinylation reaction of aromatic and aliphatic aldehydes, promoted by the merging of photoredox and nickel catalysis, has been reported. Through comprehensive investigation of reaction conditions, a valid and reproducible protocol based on nickel-mediated reductive coupling under visible light irradiation has been disclosed. The use of 3CzClIPN as the photocatalyst and Hantzsch's ester as the organic reductant replaces the commonly used reducing agents, making this method a worthy alternative. The mild reaction conditions allow access to a wide range of substituents on both the aldehyde and the alkyne. Furthermore, careful photophysical investigations have shed light on the reaction mechanism.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Review
Chemistry, Multidisciplinary
Miriam Marchi, Giuseppe Gentile, Cristian Rosso, Michele Melchionna, Paolo Fornasiero, Giacomo Filippini, Maurizio Prato
Summary: Dual photocatalysis, combining Earth-abundant nickel-based catalytic systems with visible-light-activated photoredox catalysts, has become a powerful tool for functionalization of organic molecules under mild conditions. This relatively new branch of catalysis has inspired interdisciplinary research and established itself as a dominant trend in modern organic synthesis.
Article
Chemistry, Physical
Changhua Song, Hong-Hao Zhang, Shouyun Yu
Summary: In this study, a decarboxylative allylic benzylation catalyzed by Pd/photoredox in a regio- and enantioselective manner is achieved. This method uses readily available aryl acetic acids as benzylic nucleophile equivalents without preactivation. The mild and atom-economical protocol expands the scope of coupling partners of allylic electrophiles. Additionally, vinyl epoxides can undergo this transformation smoothly, producing various chiral homoallylic alcohols bearing all-carbon quaternary stereocenters.
Article
Chemistry, Physical
Xiao-Xiao Dong, Yang Zhao, Jun Li, Hao Wang, Yuxiang Bu, Shi-Bo Cheng
Summary: A novel dual external field strategy is proposed for constructing hyperhalogens, showing the ability to enhance electron affinity, increase stability, and precisely regulate EA. Experimental validation further confirms the reliability of this strategy.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Alberto Lopez-Magano, Borja Ortin-Rubio, Inhar Imaz, Daniel Maspoch, Jose Aleman, Ruben Mas-Balleste
Summary: The functionalization of an imine-based layered covalent organic framework has allowed the obtention of a heterobimetallated material with photoactive Ir and Ni fragments immobilized within the porous structure. These heterogeneous light-mediated reactions showed enhanced activity and stability compared to analogous homogeneous systems.
Article
Chemistry, Multidisciplinary
Huan-Ming Huang, Peter Bellotti, Constantin G. Daniliuc, Frank Glorius
Summary: The radical carbonyl propargylation through dual chromium/photoredox catalysis was reported for the first time, providing a valuable method for synthesizing homopropargylic alcohols with all-carbon quaternary centers. This redox-neutral multi-component reaction shows high functional group tolerance and offers a novel approach towards the preparation of valuable synthetic architectures from simple chemicals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Marcos Veguillas, Georgina M. Rosair, Magnus W. P. Bebbington, Ai-Lan Lee
Article
Chemistry, Organic
Matthew T. Westwood, Claire J. C. Lamb, Daniel R. Sutherland, Ai-Lan Lee
Article
Chemistry, Organic
Claire J. C. Lamb, Filipe Vilela, Ai-Lan Lee
Article
Chemistry, Organic
Daniel R. Sutherland, Nidhi Sharma, Georgina M. Rosair, Ifor D. W. Samuel, Ai-Lan Lee, Eli Zysman-Colman
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Christopher G. Thomson, Callum M. S. Jones, Georgina Rosair, David Ellis, Jose Marques-Hueso, Ai-Lan Lee, Filipe Vilela
JOURNAL OF FLOW CHEMISTRY
(2020)
Review
Chemistry, Organic
Christopher G. Thomson, Ai -Lan Lee, Filipe Vilela
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Euan B. McLean, Francesca M. Cutolo, Orla J. Cassidy, David J. Burns, Ai-Lan Lee
Article
Chemistry, Organic
Christopher G. Thomson, Colin Banks, Mark Allen, Graeme Barker, Christopher R. Coxon, Ai-Lan Lee, Filipe Vilela
Summary: Recent advancements in in-line extraction and purification technology have made complex multistep synthesis in continuous flow reactor systems possible. The integration of a commercial automated flash chromatography system with a flow reactor enables continuous synthesis and isolation of products with high purity.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
David M. Kitcatt, Simon Nicolle, Ai-Lan Lee
Summary: This review summarizes the recent progress on using carboxylic acids directly as convenient radical precursors for the formation of carbon-carbon bonds.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Organic
David T. Mooney, Benjamin D. T. Donkin, Nemrud Demirel, Peter R. Moore, Ai-Lan Lee
Summary: A direct method for C-H dicarbamoylations of phenanthro-lines has been developed, allowing the direct installation of primary, secondary, and tertiary amides. This metal-, light-, and catalyst-free Minisci-type reaction is cheap, operationally simple, and scalable, significantly improving the step efficiency towards dicarbamoylated phenanthroline targets.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Euan B. McLean, David T. Mooney, David J. Burns, Ai-Lan Lee
Summary: A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed, which does not require metals, light, or catalysts, making the protocol operationally simple and more sustainable.
Article
Chemistry, Organic
David T. Mooney, Peter R. Moore, Ai-Lan Lee
Summary: A new method has been developed for the direct C-H carboxyamidation of purines, allowing for the installation of primary, secondary, and tertiary amides. This metal-free and affordable approach is operationally simple and suitable for late-stage functionalizations of biologically important molecules.
Article
Chemistry, Multidisciplinary
David M. Kitcatt, Katie A. Scott, Elena Rongione, Simon Nicolle, Ai-Lan Lee
Summary: A direct intermolecular decarboxylative Giese amidation reaction using bench stable, non-toxic and environmentally benign oxamic acids has been developed. This methodology offers an easy access to 1,4-difunctionalised compounds that are not easily accessible by other means. The developed methods, including two different photocatalytic methods and one metal- and light-free method, provide flexibility for a more general substrate scope, including complex substrates such as natural products and chiral building blocks.
Article
Chemistry, Multidisciplinary
Euan B. McLean, Vincent Gauchot, Sebastian Brunen, David J. Burns, Ai-Lan Lee
CHEMICAL COMMUNICATIONS
(2019)
