Journal
CHEMICAL SCIENCE
Volume 4, Issue 8, Pages 3269-3274Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sc51065d
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Funding
- Novartis Foundation
- Swiss Nanoscience Institute
- Marie Curie ITN (Biotrains) [FP7-ITN-238531]
- Marie Curie ITN (BioChemLig) [FP7-ITN-238434]
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In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asymmetric transfer hydrogenation of imines. Critical cofactor-protein interactions revealed by the X-ray structure of [(eta(5)-Cp*)Ir(pico 4)CI] 9 subset of WT hCA II were genetically optimized to improve the catalytic performance of the artificial metalloenzyme (68% ee, k(cat)/K-M 6.11 x 10(-3) min(-1) mM(-1)).
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