Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

Real-Time and Label-Free Detection of Cellular Response to Signaling Mediated by Distinct Subclasses of Epidermal Growth Factor Receptors

(2011) Jennifer Y. Chen et al.   ANALYTICAL CHEMISTRY

Dynamic Mass Redistribution as a Means to Measure and Differentiate Signaling via Opioid and Cannabinoid Receptors

(2011) Ellen E. Codd et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparing Label-Free Biosensors for Pharmacological Screening With Cell-Based Functional Assays

(2010) Matthew F. Peters et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Label-free whole-cell assays: expanding the scope of GPCR screening

(2010) Clay W Scott et al.   DRUG DISCOVERY TODAY

A holistic view of GPCR signaling

(2010) Terry Kenakin   NATURE BIOTECHNOLOGY

Deconvolution of complex G protein–coupled receptor signaling in live cells using dynamic mass redistribution measurements

(2010) Ralf Schröder et al.   NATURE BIOTECHNOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor

(2010) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

7TM pharmacology measured by label-free: a holistic approach to cell signalling

(2009) Magalie Rocheville et al.   CURRENT OPINION IN PHARMACOLOGY

Functional crosstalk between GPCRs: with or without oligomerization

(2009) Laurent Prezeau et al.   CURRENT OPINION IN PHARMACOLOGY

Context-Dependent Pharmacology Exhibited by Negative Allosteric Modulators of Metabotropic Glutamate Receptor 7

(2009) C. M. Niswender et al.   MOLECULAR PHARMACOLOGY

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

(2009) Terry P. Kenakin   NATURE REVIEWS DRUG DISCOVERY

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

(2008) Johannes Antony et al.   FASEB JOURNAL

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαiand Downstream Signaling Cascade Activation

(2008) Ralf Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

(2008) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY