Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
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Title
Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
Authors
Keywords
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Journal
Translational Neurodegeneration
Volume 9, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-01-17
DOI
10.1186/s40035-019-0181-9
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Note: Only part of the references are listed.- The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson’s Disease
- (2019) Maya Donyo et al. MOLECULAR CELL
- Comparative study of cerebrospinal fluid α-synuclein seeding aggregation assays for diagnosis of Parkinson's disease
- (2019) Un Jung Kang et al. MOVEMENT DISORDERS
- Ultrasensitive Detection of Aggregated α-Synuclein in Glial Cells, Human Cerebrospinal Fluid, and Brain Tissue Using the RT-QuIC Assay: New High-Throughput Neuroimmune Biomarker Assay for Parkinsonian Disorders
- (2019) Sireesha Manne et al. Journal of Neuroimmune Pharmacology
- Seeding Variability of Different Alpha Synuclein Strains in Synucleinopathies
- (2019) Niccolò Candelise et al. ANNALS OF NEUROLOGY
- α‐Synuclein real‐time quaking‐induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism
- (2019) Anouke van Rumund et al. ANNALS OF NEUROLOGY
- New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation
- (2019) Cong Liu et al. BIOCHEMICAL PHARMACOLOGY
- Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
- (2019) Chiara Maria Giulia De Luca et al. Translational Neurodegeneration
- Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity
- (2018) Esteban Luna et al. ACTA NEUROPATHOLOGICA
- The life of proteins under mechanical force
- (2018) Jörg Schönfelder et al. CHEMICAL SOCIETY REVIEWS
- Prion-like low-complexity sequences: Key regulators of protein solubility and phase behavior
- (2018) Titus Franzmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular and Clinical Aspects of Protein Aggregation Assays in Neurodegenerative Diseases
- (2018) Anna Villar-Piqué et al. MOLECULAR NEUROBIOLOGY
- α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
- (2018) Chiara Fecchio et al. MOLECULES
- Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
- (2018) Chao Peng et al. NATURE
- Neuronal Cell Death
- (2018) Michael Fricker et al. PHYSIOLOGICAL REVIEWS
- Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
- (2018) Bradley R. Groveman et al. Acta Neuropathologica Communications
- Physiological C-terminal truncation of α-synuclein potentiates the prion-like formation of pathological inclusions
- (2018) Zachary A. Sorrentino et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
- (2018) Tae-In Kam et al. SCIENCE
- High-density lipoprotein-like particle formation of Synuclein variants
- (2017) Cédric Eichmann et al. FEBS LETTERS
- SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation
- (2017) Ruth Rott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
- (2017) Poonam Thakur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Types and Strains: Their Essential Role in Understanding Protein Aggregation in Neurodegenerative Diseases
- (2017) Wiebke M. Wemheuer et al. Frontiers in Aging Neuroscience
- Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy
- (2017) Elizaveta Katorcha et al. PLoS Pathogens
- Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
- (2017) Mohammad Shahnawaz et al. JAMA Neurology
- Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology
- (2017) Jennifer Ngolab et al. Acta Neuropathologica Communications
- Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
- (2017) Shigeki Arawaka et al. Acta Neuropathologica Communications
- Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type
- (2017) Elisabet Ihse et al. Scientific Reports
- Posttranslational modifications of blood-derived alpha-synuclein as biochemical markers for Parkinson’s disease
- (2017) Hugo Vicente Miranda et al. Scientific Reports
- α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities
- (2016) Camilla Lööv et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
- (2016) Nolwen L. Rey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- ɑ-Synuclein strains and the variable pathologies of synucleinopathies
- (2016) Wouter Peelaerts et al. JOURNAL OF NEUROCHEMISTRY
- The real-time quaking-induced conversion assay for detection of human prion disease and study of other protein misfolding diseases
- (2016) Matthias Schmitz et al. Nature Protocols
- Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
- (2016) Céline Galvagnion et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo aspects of protein folding and quality control
- (2016) D. Balchin et al. SCIENCE
- Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
- (2016) Kelvin C. Luk et al. Cell Reports
- Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
- (2016) Graham Fairfoul et al. Annals of Clinical and Translational Neurology
- Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril
- (2016) Changyoun Kim et al. Scientific Reports
- Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson’s Disease via Protein Semisynthesis and Mutagenesis
- (2015) Ritwik Burai et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
- (2015) Stanley B. Prusiner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation and aggregation of intrinsically disordered peptides
- (2015) Zachary A. Levine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions
- (2014) Christopher J. Oldfield et al. Annual Review of Biochemistry
- Ubiquitination of α-synuclein and autophagy in Parkinson's disease
- (2014) Simone Engelender Autophagy
- Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
- (2014) A. K. Buell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures and Free Energy Landscapes of the A53T Mutant-Type α-Synuclein Protein and Impact of A53T Mutation on the Structures of the Wild-Type α-Synuclein Protein with Dynamics
- (2013) Orkid Coskuner et al. ACS Chemical Neuroscience
- Off-pathwayα-synuclein oligomers seem to alterα-synuclein turnover in a cell model but lack seeding capabilityin vivo
- (2013) Therese Fagerqvist et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Caudo-rostral brain spreading of α-synuclein through vagal connections
- (2013) Ayse Ulusoy et al. EMBO Molecular Medicine
- N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes
- (2013) Igor Dikiy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies
- (2013) Adrien W. Schmid et al. MOLECULAR & CELLULAR PROTEOMICS
- Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization
- (2013) Alireza Roostaee et al. Molecular Neurodegeneration
- Transmission of multiple system atrophy prions to transgenic mice
- (2013) J. C. Watts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds
- (2013) B. B. Holmes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of Ser129 phosphorylation of α-synuclein in neurodegeneration of Parkinson’s disease: a review of in vivo models
- (2013) Hiroyasu Sato et al. REVIEWS IN THE NEUROSCIENCES
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport
- (2012) Eric C. Freundt et al. ANNALS OF NEUROLOGY
- The Amyloid State of Proteins in Human Diseases
- (2012) David Eisenberg et al. CELL
- Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
- (2012) I. Ahmed et al. JOURNAL OF NEUROSCIENCE
- Protein misfolding cyclic amplification of infectious prions
- (2012) Rodrigo Morales et al. Nature Protocols
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Effect of Spermidine on Misfolding and Interactions of Alpha-Synuclein
- (2012) Alexey V. Krasnoslobodtsev et al. PLoS One
- Neuropathology underlying clinical variability in patients with synucleinopathies
- (2011) Glenda M. Halliday et al. ACTA NEUROPATHOLOGICA
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment
- (2010) Anna Gomez et al. ACTA NEUROPATHOLOGICA
- The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties
- (2010) Thomas Näsström et al. FREE RADICAL BIOLOGY AND MEDICINE
- Nucleic acid induced protein aggregation and its role in biology and pathology
- (2010) Jun Yin Frontiers in Bioscience-Landmark
- Polyamine pathway contributes to the pathogenesis of Parkinson disease
- (2010) N. M. Lewandowski et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals
- (2010) C.-S. Hwang et al. SCIENCE
- Molecular Pathogenesis of Protein Misfolding Diseases: Pathological Molecular Environments Versus Quality Control Systems Against Misfolded Proteins
- (2009) H. Naiki et al. JOURNAL OF BIOCHEMISTRY
- Dopamine and the Dopamine Oxidation Product 5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner
- (2009) Chi L.L. Pham et al. JOURNAL OF MOLECULAR BIOLOGY
- Human variant Creutzfeldt-Jakob disease and sheep scrapie PrPres detection using seeded conversion of recombinant prion protein
- (2009) C. D. Orru et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation
- (2008) Shamim Shaikh et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Transplanted dopaminergic neurons develop PD pathologic changes: A second case report
- (2008) Jeffrey H. Kordower et al. MOVEMENT DISORDERS
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
- (2008) Ryuichiro Atarashi et al. NATURE METHODS
- EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
- (2008) Dagmar E Ehrnhoefer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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