An Overview of Influenza Viruses and Vaccines

Sialic Acid Receptors: The Key to Solving the Enigma of Zoonotic Virus Spillover

(2021) Suresh V Kuchipudi et al.   Viruses-Basel

Vaccines and vaccination: history and emerging issues

(2021) Veysel Kayser et al.   Human Vaccines & Immunotherapeutics

Influenza Neuraminidase: A Neglected Protein and Its Potential for a Better Influenza Vaccine

(2020) Luca T. Giurgea et al.   Vaccines

Characterization of Inactivated Influenza Vaccines Used in the Russian National Immunization Program

(2020) Mikhail Tarasov et al.   Vaccines

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Preparation-free method can enable rapid surfactant screening during industrial processing of influenza vaccines

(2019) Ziya Sahin et al.   VACCINE

Current and future influenza vaccines

(2019) Seiya Yamayoshi et al.   NATURE MEDICINE

Emerging Influenza D Virus Threat: What We Know so Far!

(2019) Kumari Asha et al.   Journal of Clinical Medicine

Hydrophobic-interaction chromatography for purification of influenza A and B virus

(2019) Thomas Weigel et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate—Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults

(2019) Stéphane Pillet et al.   PLoS One

Influenza M2 virus-like particle vaccination enhances protection in combination with avian influenza HA VLPs

(2019) Hae-Ji Kang et al.   PLoS One

Inactivation methods for whole influenza vaccine production

(2019) Ailar Sabbaghi et al.   REVIEWS IN MEDICAL VIROLOGY

The 1918 influenza pandemic: 100 years of questions answered and unanswered

(2019) Jeffery K. Taubenberger et al.   Science Translational Medicine

Comparing influenza vaccine effectiveness between cell-derived and egg-derived vaccines, 2017–2018 influenza season

(2019) Laurie DeMarcus et al.   VACCINE

Cell-Based Quadrivalent Inactivated Influenza Virus Vaccine (Flucelvax® Tetra/Flucelvax Quadrivalent®): A Review in the Prevention of Influenza

(2019) Yvette N. Lamb   DRUGS

Host factors impact vaccine efficacy: implications for seasonal and universal influenza vaccine programs

(2019) Santosh Dhakal et al.   JOURNAL OF VIROLOGY

Heterogeneity in influenza seasonality and vaccine effectiveness in Australia, Chile, New Zealand and South Africa: early estimates of the 2019 influenza season

(2019) Sheena G Sullivan et al.   Eurosurveillance

Nanoparticles in influenza subunit vaccine development: Immunogenicity enhancement

(2019) Atin Khalaj‐Hedayati et al.   Influenza and Other Respiratory Viruses

Why Glycosylation Matters in Building a Better Flu Vaccine

(2019) Deborah Chang et al.   MOLECULAR & CELLULAR PROTEOMICS

Immunogenicity and safety of MF59-adjuvanted quadrivalent influenza vaccine versus standard and alternate B strain MF59-adjuvanted trivalent influenza vaccines in older adults

(2019) Brandon Essink et al.   VACCINE

A Computationally Optimized Broadly Reactive Antigen Subtype–Specific Influenza Vaccine Strategy Elicits Unique Potent Broadly Neutralizing Antibodies against Hemagglutinin

(2019) Giuseppe A. Sautto et al.   JOURNAL OF IMMUNOLOGY

Standardisation of inactivated influenza vaccines-Learning from history

(2018) John M. Wood et al.   Influenza and Other Respiratory Viruses

Intramuscular and intranasal immunization with an H7N9 influenza virus-like particle vaccine protects mice against lethal influenza virus challenge

(2018) Zhiguang Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Chasing Seasonal Influenza — The Need for a Universal Influenza Vaccine

(2018) Catharine I. Paules et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adventitious viruses in insect cell lines used for recombinant protein expression

(2018) Christoph Geisler et al.   PROTEIN EXPRESSION AND PURIFICATION

Comparison of single radial immunodiffusion, SDS-PAGE and HPLC potency assays for inactivated influenza vaccines shows differences in ability to predict immunogenicity of haemagglutinin antigen

(2018) Othmar G. Engelhardt et al.   VACCINE

Affinity chromatography for vaccines manufacturing: Finally ready for prime time?

(2018) Mochao Zhao et al.   VACCINE

A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles

(2018) Alejandro Ramirez et al.   VACCINE

Influenza Virus: Dealing with a Drifting and Shifting Pathogen

(2018) Hyunsuh Kim et al.   VIRAL IMMUNOLOGY

Glycosylation of Hemagglutinin and Neuraminidase of Influenza A Virus as Signature for Ecological Spillover and Adaptation among Influenza Reservoirs

(2018) Paul Kim et al.   Viruses-Basel

Sequential Immunizations with heterosubtypic virus-like particles elicit cross protection against divergent influenza A viruses in mice

(2018) Yuan Luo et al.   Scientific Reports

Adjuvanted influenza vaccines

(2018) John S. Tregoning et al.   Human Vaccines & Immunotherapeutics

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

(2018) Daniela S. Rajão et al.   Frontiers in Microbiology

Novel Platforms for the Development of a Universal Influenza Vaccine

(2018) Arun Kumar et al.   Frontiers in Immunology

Reassessing the global mortality burden of the 1918 influenza pandemic.

(2018) Peter Spreeuwenberg et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Immunogenicity and safety of a quadrivalent inactivated influenza vaccine in children 6–59 months of age: A phase 3, randomized, noninferiority study

(2018) Victoria A. Statler et al.   VACCINE

Influenza virus N-linked glycosylation and innate immunity

(2018) Ian A. York et al.   BIOSCIENCE REPORTS

Historical and clinical aspects of the 1918 H1N1 pandemic in the United States

(2018) Barbara Jester et al.   VIROLOGY

The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells

(2017) Yipu Lin et al.   Influenza and Other Respiratory Viruses

The Interplay between the Host Receptor and Influenza Virus Hemagglutinin and Neuraminidase

(2017) Lauren Byrd-Leotis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Duration of Influenza Vaccine Effectiveness: A Systematic Review, Meta-analysis, and Meta-regression of Test-Negative Design Case-Control Studies

(2017) Barnaby Young et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza

(2017) Catharine Paules et al.   LANCET

Evaluating the immunogenicity and safety of a BiondVax-developed universal influenza vaccine (Multimeric-001) either as a standalone vaccine or as a primer to H5N1 influenza vaccine

(2017) Eva van Doorn et al.   MEDICINE

Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge

(2017) Christopher P. Karch et al.   Nanomedicine-Nanotechnology Biology and Medicine

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nile Red fluorescence spectrum decomposition enables rapid screening of large protein aggregates in complex biopharmaceutical formulations like influenza vaccines

(2017) Ziya Sahin et al.   VACCINE

Safety of quadrivalent live attenuated influenza vaccine in subjects aged 2–49years

(2017) Roger Baxter et al.   VACCINE

Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry

(2017) Esteban Cruz et al.   Human Vaccines & Immunotherapeutics

An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers

(2017) Lukas Kaufmann et al.   Jove-Journal of Visualized Experiments

Influenza: The Once and Future Pandemic

(2017) Jeffery K. Taubenberger et al.   PUBLIC HEALTH REPORTS

Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

(2016) Daniel F. Hoft et al.   Clinical and Vaccine Immunology

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Functional balance between neuraminidase and haemagglutinin in influenza viruses

(2016) A. Gaymard et al.   CLINICAL MICROBIOLOGY AND INFECTION

Fluzone® High-Dose Influenza Vaccine

(2016) Corwin A. Robertson et al.   Expert Review of Vaccines

An overview of the regulation of influenza vaccines in the United States

(2016) Jerry P. Weir et al.   Influenza and Other Respiratory Viruses

Size distribution analysis of influenza virus particles using size exclusion chromatography

(2016) Judith Vajda et al.   JOURNAL OF CHROMATOGRAPHY A

Global Mortality Impact of the 1957–1959 Influenza Pandemic

(2016) Cécile Viboud et al.   JOURNAL OF INFECTIOUS DISEASES

Evaluation of Microflow Digital Imaging Particle Analysis for Sub-Visible Particles Formulated with an Opaque Vaccine Adjuvant

(2016) Grant E. Frahm et al.   PLoS One

Vaccine provision: Delivering sustained & widespread use

(2016) Scott Preiss et al.   VACCINE

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

(2016) Maria Pelliccia et al.   Nature Communications

Quantitative determination of the surfactant-induced split ratio of influenza virus by fluorescence spectroscopy

(2016) Kenny Kwon Ho Lee et al.   Human Vaccines & Immunotherapeutics

Induction of mucosal immunity through systemic immunization: Phantom or reality?

(2016) Fei Su et al.   Human Vaccines & Immunotherapeutics

Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

(2016) Ignacio Mena et al.   eLife

Influenza Vaccine Manufacturing: Effect of Inactivation, Splitting and Site of Manufacturing. Comparison of Influenza Vaccine Production Processes

(2016) Theone C. Kon et al.   PLoS One

Entrapment of H1N1 Influenza Virus Derived Conserved Peptides in PLGA Nanoparticles Enhances T Cell Response and Vaccine Efficacy in Pigs

(2016) Jagadish Hiremath et al.   PLoS One

Current and next generation influenza vaccines: Formulation and production strategies

(2015) Peter C. Soema et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evidence update: GlaxoSmithKline’s inactivated quadrivalent influenza vaccines

(2015) Rafik Bekkat-Berkani et al.   Expert Review of Vaccines

Recombinant hemagglutinin protein vaccine: a new option in immunization against influenza

(2015) Andres F Gutierrez et al.   Future Virology

The coexistence or replacement of two subtypes of influenza

(2015) Sarder Mohammed Asaduzzaman et al.   MATHEMATICAL BIOSCIENCES

Relationship of the quaternary structure of human secretory IgA to neutralization of influenza virus

(2015) Tadaki Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of high-yield influenza A virus vaccine viruses

(2015) Jihui Ping et al.   Nature Communications

H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps

(2015) Hang Xie et al.   Scientific Reports

Investigation into alternative testing methodologies for characterization of influenza virus vaccine

(2015) Tracy Tay et al.   Human Vaccines & Immunotherapeutics

Cell culture-based influenza vaccines: A necessary and indispensable investment for the future

(2015) Nagendra R Hegde   Human Vaccines & Immunotherapeutics

Current and Emerging Cell Culture Manufacturing Technologies for Influenza Vaccines

(2015) Ernest Milián et al.   Biomed Research International

Physicochemical and functional characterization of vaccine antigens and adjuvants

(2014) Antu K Dey et al.   Expert Review of Vaccines

Development and application of a reversed-phase high-performance liquid chromatographic method for quantitation and characterization of a Chikungunya virus-like particle vaccine

(2014) Anastasija Shytuhina et al.   JOURNAL OF CHROMATOGRAPHY A

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine: Results from a double-blinded, randomized Phase I clinical trial in healthy Asian volunteers

(2014) Jenny G.H. Low et al.   VACCINE

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen

(2014) Teddy Wohlbold et al.   Viruses-Basel

PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine

(2014) Gervais Rioux et al.   JOURNAL OF NANOBIOTECHNOLOGY

Enhanced Influenza VLP vaccines comprising matrix-2 ectodomain and nucleoprotein epitopes protects mice from lethal challenge

(2013) Xiao Gao et al.   ANTIVIRAL RESEARCH

Traditional and New Influenza Vaccines

(2013) S.-S. Wong et al.   CLINICAL MICROBIOLOGY REVIEWS

Inactivated Quadrivalent Split-Virus Seasonal Influenza Vaccine (Fluarix® Quadrivalent): A Review of Its Use in the Prevention of Disease Caused by Influenza A and B

(2013) Kate McKeage   DRUGS

Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses

(2013) E. R. Job et al.   JOURNAL OF IMMUNOLOGY

Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms

(2013) Yanming An et al.   JOURNAL OF PROTEOME RESEARCH

Spherical Influenza Viruses Have a Fitness Advantage in Embryonated Eggs, while Filament-Producing Strains Are Selected In Vivo

(2013) J. Seladi-Schulman et al.   JOURNAL OF VIROLOGY

The antigenic architecture of the hemagglutinin of influenza H5N1 viruses

(2013) Tony Velkov et al.   MOLECULAR IMMUNOLOGY

The Specificity of Targeted Vaccines for APC Surface Molecules Influences the Immune Response Phenotype

(2013) Gunnveig Grødeland et al.   PLoS One

Analytical approaches to assess the degradation of therapeutic proteins

(2013) Vasco Filipe et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

Quadrivalent influenza vaccine in the United States

(2013) Manika Suryadevara et al.   Human Vaccines & Immunotherapeutics

Safety and Immunogenicity of Multimeric-001—a Novel Universal Influenza Vaccine

(2012) Jacob Atsmon et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Toward Animal Cell Culture-Based Influenza Vaccine Design: Viral Hemagglutinin N-Glycosylation Markedly Impacts Immunogenicity

(2012) J. Hutter et al.   JOURNAL OF IMMUNOLOGY

Evidence for N-Glycan Shielding of Antigenic Sites during Evolution of Human Influenza A Virus Hemagglutinin

(2012) Y. Kobayashi et al.   JOURNAL OF VIROLOGY

Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

(2012) R. Hai et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Hemagglutination Inhibition Titers Generated Using Temporally Matched Serum and Plasma Samples

(2012) Gabriel N. Defang et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: Epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011

(2012) Alexander I. Klimov et al.   VACCINE

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

(2011) D. Corti et al.   SCIENCE

Safety and immunogenicity of a virus-like particle pandemic influenza A (H1N1) 2009 vaccine in a blinded, randomized, placebo-controlled trial of adults in Mexico

(2011) Constantino López-Macías et al.   VACCINE

Importance of viral genomic composition in modulating glycoprotein content on the surface of influenza virus particles

(2011) Vincent Moulès et al.   VIROLOGY

Influenza Vaccine and Adjuvant

(2011) Tetsuo NAKAYAMA   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Glycan Shielding of the Influenza Virus Hemagglutinin Contributes to Immunopathology in Mice

(2010) Keith Wanzeck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins

(2010) Steven J. Gamblin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FluBlok, a next generation influenza vaccine manufactured in insect cells

(2009) Manon M.J. Cox et al.   BIOLOGICALS

Intradermal influenza vaccine for older adults: A randomized controlled multicenter phase III study

(2009) Robert Arnou et al.   VACCINE

Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009–2010 Northern Hemisphere season

(2009) Ian G. Barr et al.   VACCINE

Influenza virus morphogenesis and budding

(2009) Debi P. Nayak et al.   VIRUS RESEARCH

FluBlok, a recombinant hemagglutinin influenza vaccine

(2008) Manon M.J. Cox et al.   Influenza and Other Respiratory Viruses

The Cotranslational Maturation Program for the Type II Membrane GlycoproteinInfluenzaNeuraminidase

(2008) Ning Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry analysis of the influenza virus

(2008) Kevin M. Downard et al.   MASS SPECTROMETRY REVIEWS

Seasonal inactivated influenza virus vaccines

(2008) Robert B. Couch   VACCINE

Vaccination and antigenic drift in influenza

(2008) Maciej F. Boni   VACCINE

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE

Emerging influenza

(2007) Emmie de Wit et al.   JOURNAL OF CLINICAL VIROLOGY