The 1918 influenza pandemic: 100 years of questions answered and unanswered

A review of the 1918 herald pandemic wave: importance for contemporary pandemic response strategies

(2018) Lone Simonsen et al.   ANNALS OF EPIDEMIOLOGY

Co-circulation of multiple genotypes of influenza A (H7N9) viruses in eastern China, 2016-2017

(2018) Xian Qi et al.   ARCHIVES OF VIROLOGY

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

(2018) Jake Dunning et al.   NATURE IMMUNOLOGY

Contribution of cryptic epitopes in designing a group A streptococcal vaccine

(2018) Victoria Ozberk et al.   Human Vaccines & Immunotherapeutics

Update: Influenza Activity — United States, October 1, 2017–February 3, 2018

(2018) Alicia P. Budd et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

The Mother of All Pandemics Is 100 Years Old (and Going Strong)!

(2018) David M. Morens et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

US had record flu deaths last year, says CDC

(2018) Owen Dyer   BMJ-British Medical Journal

GISAID: Global initiative on sharing all influenza data – from vision to reality

(2017) Yuelong Shu et al.   Eurosurveillance

The Global Threat of Animal Influenza Viruses of Zoonotic Concern: Then and Now

(2017) Marc-Alain Widdowson et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza A and methicillin-resistant Staphylococcus aureus co-infection in rhesus macaques – A model of severe pneumonia

(2016) Daniel S. Chertow et al.   ANTIVIRAL RESEARCH

Genomic Signatures for Avian H7N9 Viruses Adapting to Humans

(2016) Guang-Wu Chen et al.   PLoS One

1918 Influenza receptor binding domain variants bind and replicate in primary human airway cells regardless of receptor specificity

(2016) A. Sally Davis et al.   VIROLOGY

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

(2016) Yasuha Arai et al.   PLoS Pathogens

Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

(2016) Ignacio Mena et al.   eLife

Pandemic influenza - including a risk assessment of H5N1

(2016) J.K. TAUBENBERGER et al.   REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES

The Role of Viral, Host, and Secondary Bacterial Factors in Influenza Pathogenesis

(2015) John C. Kash et al.   AMERICAN JOURNAL OF PATHOLOGY

1918 pandemic influenza virus andStreptococcus pneumoniaeco-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans

(2015) Kathie-Anne Walters et al.   JOURNAL OF PATHOLOGY

Global migration of influenza A viruses in swine

(2015) Martha I. Nelson et al.   Nature Communications

Universal Influenza Vaccines: To Dream the Possible Dream?

(2015) Jae-Keun Park et al.   ACS Infectious Diseases

Influenza Circulation in United States Army Training Camps Before and During the 1918 Influenza Pandemic: Clues to Early Detection of Pandemic Viral Emergence

(2015) D. S. Chertow et al.   Open Forum Infectious Diseases

Where does a Staphylococcus aureus vaccine stand?

(2014) V.G. Fowler et al.   CLINICAL MICROBIOLOGY AND INFECTION

How Low Is the Risk of Influenza A(H5N1) Infection?

(2014) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Avian Influenza A(H5N1) and A(H9N2) Seroprevalence and Risk Factors for Infection Among Egyptians: A Prospective, Controlled Seroepidemiological Study

(2014) Mokhtar R. Gomaa et al.   JOURNAL OF INFECTIOUS DISEASES

Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus

(2014) M. Worobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin

(2014) Li Qi et al.   mBio

Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice

(2013) John C. Kash et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bacterial Coinfection in Influenza

(2013) Daniel S. Chertow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier

(2013) B. Manz et al.   JOURNAL OF VIROLOGY

Pandemic Influenza Viruses — Hoping for the Road Not Taken

(2013) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza Viruses: Breaking All the Rules

(2013) J. K. Taubenberger et al.   mBio

H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity

(2013) D. M. Morens et al.   mBio

Newer influenza antivirals, biotherapeutics and combinations

(2012) Frederick G. Hayden   Influenza and Other Respiratory Viruses

Age- and Sex-Specific Mortality Associated With the 1918–1919 Influenza Pandemic in Kentucky

(2012) Cécile Viboud et al.   JOURNAL OF INFECTIOUS DISEASES

High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic

(2012) Yong-Li Xiao et al.   JOURNAL OF PATHOLOGY

Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in Mice

(2012) L. Qi et al.   JOURNAL OF VIROLOGY

Engineering H5N1 avian influenza viruses to study human adaptation

(2012) David M. Morens et al.   NATURE

IFITM3 restricts the morbidity and mortality associated with influenza

(2012) Aaron R. Everitt et al.   NATURE

The Potential of Avian H1N1 Influenza A Viruses to Replicate and Cause Disease in Mammalian Models

(2012) Zeynep A. Koçer et al.   PLoS One

Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis

(2012) T. T. Wang et al.   SCIENCE

In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient

(2012) Matthew J. Memoli et al.   VIROLOGY

Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past

(2012) J. K. Taubenberger et al.   mBio

Immunization with 1976 swine H1N1- or 2009 pandemic H1N1-inactivated vaccines protects mice from a lethal 1918 influenza infection

(2011) Judith D. Easterbrook et al.   Influenza and Other Respiratory Viruses

NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferrets

(2011) I. Meunier et al.   JOURNAL OF GENERAL VIROLOGY

Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak

(2011) Z.-M. Sheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pandemic influenza: certain uncertainties

(2011) David M. Morens et al.   REVIEWS IN MEDICAL VIROLOGY

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding

(2011) Li Qi et al.   VIROLOGY

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

(2011) J. C. Kash et al.   mBio

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Historical thoughts on influenza viral ecosystems, or behold a pale horse, dead dogs, failing fowl, and sick swine

(2010) David M. Morens et al.   Influenza and Other Respiratory Viruses

Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

(2010) S. Herfst et al.   JOURNAL OF VIROLOGY

Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine

(2010) Gary J Nabel et al.   NATURE MEDICINE

Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models

(2010) Wenjun Ma et al.   VIROLOGY

The 2009 H1N1 Pandemic Influenza Virus: What Next?

(2010) D. M. Morens et al.   mBio

The PB2-E627K Mutation Attenuates Viruses Containing the 2009 H1N1 Influenza Pandemic Polymerase

(2010) B. W. Jagger et al.   mBio

Understanding Influenza Backward

(2009) David M. Morens   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Recent Human Influenza A/H3N2 Virus Evolution Driven by Novel Selection Factors in Addition to Antigenic Drift

(2009) Matthew J. Memoli et al.   JOURNAL OF INFECTIOUS DISEASES

Different Evolutionary Trajectories of European Avian-Like and Classical Swine H1N1 Influenza A Viruses

(2009) E. J. Dunham et al.   JOURNAL OF VIROLOGY

Role of Sialic Acid Binding Specificity of the 1918 Influenza Virus Hemagglutinin Protein in Virulence and Pathogenesis for Mice

(2009) L. Qi et al.   JOURNAL OF VIROLOGY

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

The Persistent Legacy of the 1918 Influenza Virus

(2009) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dating the emergence of pandemic influenza viruses

(2009) Gavin J. D. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

An early ‘classical’ swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice

(2009) Matthew J. Memoli et al.   VIROLOGY

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

Epidemiologic Characterization of the 1918 Influenza Pandemic Summer Wave in Copenhagen: Implications for Pandemic Control Strategies

(2008) Viggo Andreasen et al.   JOURNAL OF INFECTIOUS DISEASES

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets

(2008) T. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathology of human influenza revisited

(2008) Thijs Kuiken et al.   VACCINE

Patterns of Evolution and Host Gene Mimicry in Influenza and Other RNA Viruses

(2008) Benjamin D. Greenbaum et al.   PLoS Pathogens

Multiple Reassortment Events in the Evolutionary History of H1N1 Influenza A Virus Since 1918

(2008) Martha I. Nelson et al.   PLoS Pathogens

The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds

(2008) Vivien G. Dugan et al.   PLoS Pathogens

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens