Why Glycosylation Matters in Building a Better Flu Vaccine

Mass spectrometric analysis of glycosylated viral proteins

(2018) David J. Harvey   Expert Review of Proteomics

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus

(2018) Martin van Eijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Universal Influenza Vaccine: The Strategic Plan for the National Institute of Allergy and Infectious Diseases

(2018) Emily J Erbelding et al.   JOURNAL OF INFECTIOUS DISEASES

Development of a data independent acquisition mass spectrometry workflow to enable glycopeptide analysis without predefined glycan compositional knowledge

(2018) Chi-Hung Lin et al.   Journal of Proteomics

Deep sequencing of complex proteoglycans: a novel strategy for high coverage and site-specific identification of glycosaminoglycan-linked peptides

(2018) Joshua A. Klein et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural insights into the design of novel anti-influenza therapies

(2018) Nicholas C. Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibody Immunodominance: The Key to Understanding Influenza Virus Antigenic Drift

(2018) Meghan O. Altman et al.   VIRAL IMMUNOLOGY

A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site

(2018) Nicholas C. Wu et al.   Nature Communications

Structural insights into the design of novel anti-influenza therapies

(2018) Nicholas C. Wu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs

(2018) Ivan Kosik et al.   PLoS Pathogens

Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens

(2018) Seth J Zost et al.   JOURNAL OF INFECTIOUS DISEASES

Ancestral and Compensatory Mutations that Promote Antiviral Resistance in Influenza N1 Neuraminidase Revealed by a Phylonumerics Approach

(2018) Elma H. Akand et al.   JOURNAL OF MOLECULAR EVOLUTION

A Perspective on the Structural and Functional Constraints for Immune Evasion: Insights from Influenza Virus

(2017) Nicholas C. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

Influenza

(2017) Catharine Paules et al.   LANCET

Mutational analysis employing a phylogenetic mass tree approach in a study of the evolution of the influenza virus

(2017) Elma H. Akand et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

The evolution of seasonal influenza viruses

(2017) Velislava N. Petrova et al.   NATURE REVIEWS MICROBIOLOGY

Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry

(2017) Esteban Cruz et al.   Human Vaccines & Immunotherapeutics

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

(2017) Nicholas C. Wu et al.   PLoS Pathogens

N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins

(2017) Máximo Lopez Medus et al.   Scientific Reports

Use of an informed search space maximizes confidence of site-specific assignment of glycoprotein glycosylation

(2016) Kshitij Khatri et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Site-specific analysis of changes in the glycosylation of proteins in liver cirrhosis using data-independent workflow with soft fragmentation

(2016) Miloslav Sanda et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Data Independent Analysis of IgG Glycoforms in Samples of Unfractionated Human Plasma

(2016) Miloslav Sanda et al.   ANALYTICAL CHEMISTRY

Functional balance between neuraminidase and haemagglutinin in influenza viruses

(2016) A. Gaymard et al.   CLINICAL MICROBIOLOGY AND INFECTION

Carbohydrates as T-cell antigens with implications in health and disease

(2016) Lina Sun et al.   GLYCOBIOLOGY

Glycosylation Characterization of an Influenza H5N7 Hemagglutinin Series with Engineered Glycosylation Patterns: Implications for Structure–Function Relationships

(2016) Lisa M. Parsons et al.   JOURNAL OF PROTEOME RESEARCH

The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics

(2016) Hannes Hinneburg et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

SWATH-MS Glycoproteomics Reveals Consequences of Defects in the Glycosylation Machinery

(2016) Lucia F. Zacchi et al.   MOLECULAR & CELLULAR PROTEOMICS

Maturing Glycoproteomics Technologies Provide Unique Structural Insights into theN-glycoproteome and Its Regulation in Health and Disease

(2016) Morten Thaysen-Andersen et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrated Omics and Computational Glycobiology Reveal Structural Basis for Influenza A Virus Glycan Microheterogeneity and Host Interactions

(2016) Kshitij Khatri et al.   MOLECULAR & CELLULAR PROTEOMICS

Glycosylation changes in the globular head of H3N2 influenza hemagglutinin modulate receptor binding without affecting virus virulence

(2016) Irina V. Alymova et al.   Scientific Reports

FluClass: A novel algorithm and approach to score and visualize the phylogeny of the influenza virus using mass spectrometry

(2015) Shiyong Ma et al.   ANALYTICA CHIMICA ACTA

Influenza Vaccines: Challenges and Solutions

(2015) Katherine Houser et al.   Cell Host & Microbe

A review of methods for interpretation of glycopeptide tandem mass spectral data

(2015) Han Hu et al.   GLYCOCONJUGATE JOURNAL

Glycosylation Analysis of Engineered H3N2 Influenza A Virus Hemagglutinins with Sequentially Added Historically Relevant Glycosylation Sites

(2015) Yanming An et al.   JOURNAL OF PROTEOME RESEARCH

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Lamprey VLRB response to influenza virus supports universal rules of immunogenicity and antigenicity

(2015) Meghan O Altman et al.   eLife

Origins of the reassortant 2009 pandemic influenza virus through proteotyping with mass spectrometry

(2014) Neil D. Fernandes et al.   JOURNAL OF MASS SPECTROMETRY

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

Conserved and host-specific features of influenza virion architecture

(2014) Edward C. Hutchinson et al.   Nature Communications

High-throughput profiling of influenza A virus hemagglutinin gene at single-nucleotide resolution

(2014) Nicholas C. Wu et al.   Scientific Reports

The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

(2014) Bargavi Thyagarajan et al.   eLife

Subtyping of influenza neuraminidase using mass spectrometry

(2013) An P. Nguyen et al.   ANALYST

A comprehensive map of the influenza A virus replication cycle

(2013) Yukiko Matsuoka et al.   BMC Systems Biology

Comparative Glycomics Analysis of Influenza Hemagglutinin (H5N1) Produced in Vaccine Relevant Cell Platforms

(2013) Yanming An et al.   JOURNAL OF PROTEOME RESEARCH

N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses

(2013) X. Sun et al.   JOURNAL OF VIROLOGY

Multiplexed and data-independent tandem mass spectrometry for global proteome profiling

(2013) John D. Chapman et al.   MASS SPECTROMETRY REVIEWS

Adaptive immune activation: glycosylation does matter

(2013) Margreet A Wolfert et al.   Nature Chemical Biology

Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies

(2013) A. K. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

(2013) B. F. Koel et al.   SCIENCE

Carbohydrates and T cells: A sweet twosome

(2013) Fikri Y. Avci et al.   SEMINARS IN IMMUNOLOGY

Antigenically intact hemagglutinin in circulating avian and swine influenza viruses and potential for H3N2 pandemic

(2013) Kannan Tharakaraman et al.   Scientific Reports

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Effective Use of Mass Spectrometry for Glycan and Glycopeptide Structural Analysis

(2012) Nancy Leymarie et al.   ANALYTICAL CHEMISTRY

AntigenMap 3D: an online antigenic cartography resource

(2012) J. L. Barnett et al.   BIOINFORMATICS

FluShuffle and FluResort: new algorithms to identify reassorted strains of the influenza virus by mass spectrometry

(2012) Aaron TL Lun et al.   BMC BIOINFORMATICS

Automated glycopeptide analysis--review of current state and future directions

(2012) D. C. Dallas et al.   BRIEFINGS IN BIOINFORMATICS

Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses

(2012) A. Verma et al.   JOURNAL OF IMMUNOLOGY

Glycan-Dependent Immunogenicity of Recombinant Soluble Trimeric Hemagglutinin

(2012) R. P. de Vries et al.   JOURNAL OF VIROLOGY

Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

(2012) Ludovic C. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative analysis of peptides and proteins in biomedicine by targeted mass spectrometry

(2012) Michael A Gillette et al.   NATURE METHODS

Immunodominance of Antigenic Site B over Site A of Hemagglutinin of Recent H3N2 Influenza Viruses

(2012) Lyubov Popova et al.   PLoS One

Comparative characterization of the glycosylation profiles of an influenza hemagglutinin produced in plant and insect hosts

(2012) Sheng Zhang et al.   PROTEOMICS

Mapping the Phosphoproteome of Influenza A and B Viruses by Mass Spectrometry

(2012) Edward C. Hutchinson et al.   PLoS Pathogens

Evolution of H5N1 influenza virus through proteotyping of hemagglutinin with high resolution mass spectrometry

(2011) Ji-Won Ha et al.   ANALYST

Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

(2011) Wei-Chuan Chang et al.   BMC IMMUNOLOGY

Characterization of a Recombinant Influenza Vaccine Candidate Using Complementary LC-MS Methods

(2011) Hongwei Xie et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mutagenesis of Surfactant Protein D Informed by Evolution and X-ray Crystallography Enhances Defenses against Influenza A Virusin Vivo

(2011) Erika Crouch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice

(2011) M. D. Tate et al.   JOURNAL OF IMMUNOLOGY

Proteotyping to Establish Gene Origin within Reassortant Influenza Viruses

(2011) Ji-won Ha et al.   PLoS One

Glycosylation Site Alteration in the Evolution of Influenza A (H1N1) Viruses

(2011) Shisheng Sun et al.   PLoS One

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin

(2011) J. R. R. Whittle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fitness costs limit influenza A virus hemagglutinin glycosylation as an immune evasion strategy

(2011) S. R. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic distance measurements for seasonal influenza vaccine selection

(2011) Zhipeng Cai et al.   VACCINE

Glycan Shielding of the Influenza Virus Hemagglutinin Contributes to Immunopathology in Mice

(2010) Keith Wanzeck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rapid Differentiation of Seasonal and Pandemic H1N1 Influenza through Proteotyping of Viral Neuraminidase with Mass Spectrometry

(2010) Alexander B. Schwahn et al.   ANALYTICAL CHEMISTRY

Does Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?

(2010) Tom Reichert et al.   BMC INFECTIOUS DISEASES

Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

(2010) C.-J. Wei et al.   Science Translational Medicine

Glycosylation Focuses Sequence Variation in the Influenza A Virus H1 Hemagglutinin Globular Domain

(2010) Suman R. Das et al.   PLoS Pathogens

Subtyping of the Influenza Virus by High Resolution Mass Spectrometry

(2009) Alexander B. Schwahn et al.   ANALYTICAL CHEMISTRY

Antigenicity of a Type A Influenza Virus Through Comparison of Hemagglutination Inhibition and Mass Spectrometry Immunoassays

(2009) Alexander B. Schwahn et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Proximal Glycans Outside of the Epitopes Regulate the Presentation of HIV-1 Envelope gp120 Helper Epitopes

(2009) Hualin Li et al.   JOURNAL OF IMMUNOLOGY

Enhancement of Antiviral Activity of Collectin Trimers through Cross-Linking and Mutagenesis of the Carbohydrate Recognition Domain

(2009) Mitchell R. White et al.   Journal of Innate Immunity

Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift

(2009) S. E. Hensley et al.   SCIENCE

Glycan analysis in cell culture-based influenza vaccine production: Influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin

(2009) Jana Schwarzer et al.   VACCINE

When can glycopeptides be assigned based solely on high-resolution mass spectrometry data?

(2008) Heather Desaire et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Mass spectrometry analysis of the influenza virus

(2008) Kevin M. Downard et al.   MASS SPECTROMETRY REVIEWS

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

(2008) Aarthi Chandrasekaran et al.   NATURE BIOTECHNOLOGY

Changing Selective Pressure during Antigenic Changes in Human Influenza H3

(2008) Benjamin P. Blackburne et al.   PLoS Pathogens