RNA-induced epigenetic silencing inhibits HIV-1 reactivation from latency

CRISPR-Cas based antiviral strategies against HIV-1

(2018) Gang Wang et al.   VIRUS RESEARCH

CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo

(2017) Lei Xu et al.   MOLECULAR THERAPY

In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment

(2017) Cari F. Kessing et al.   Cell Reports

Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study

(2016) R Kaminski et al.   GENE THERAPY

CRISPR-mediated Activation of Latent HIV-1 Expression

(2016) Prajit Limsirichai et al.   MOLECULAR THERAPY

Transcriptional gene silencing in humans

(2016) Marc S. Weinberg et al.   NUCLEIC ACIDS RESEARCH

CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape

(2016) Zhen Wang et al.   Cell Reports

PKC  Is an Essential Mediator of Prostate Cancer Bone Metastasis

(2015) A. Gutierrez-Uzquiza et al.   MOLECULAR CANCER RESEARCH

Bryostatin activates HIV-1 latent expression in human astrocytes through a PKC and NF-ĸB-dependent mechanism

(2015) Laura Díaz et al.   Scientific Reports

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Novel RNA Duplex Locks HIV-1 in a Latent State via Chromatin-mediated Transcriptional Silencing

(2015) Chantelle Ahlenstiel et al.   Molecular Therapy-Nucleic Acids

NF-κB target microRNAs and their target genes in TNFα-stimulated HeLa Cells

(2014) Fei Zhou et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Erk1/2 Activity Promotes Chromatin Features and RNAPII Phosphorylation at Developmental Promoters in Mouse ESCs

(2014) Wee-Wei Tee et al.   CELL

TNF-  levels in HIV-infected patients after long-term suppressive cART persist as high as in elderly, HIV-uninfected subjects

(2014) R. S. De Pablo-Bernal et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An HIV-Encoded Antisense Long Noncoding RNA Epigenetically Regulates Viral Transcription

(2014) Sheena Saayman et al.   MOLECULAR THERAPY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapy

(2014) A. R. Cillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells

(2014) M. Allo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

(2014) Julian H. Elliott et al.   PLoS Pathogens

The Majority of HIV Type 1 DNA in Circulating CD4+ T Lymphocytes Is Present in Non-Gut-Homing Resting Memory CD4+ T Cells

(2013) Kristin McBride et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Kinetic and Thermodynamic Rationale for Suberoylanilide Hydroxamic Acid Being a Preferential Human Histone Deacetylase 8 Inhibitor As Compared to the Structurally Similar Ligand, Trichostatin A

(2013) Raushan K. Singh et al.   BIOCHEMISTRY

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

(2013) Florian Thaler et al.   ChemMedChem

Characterization of genome-wide binding of NF-κB in TNFα-stimulated HeLa cells

(2013) Yujun Xing et al.   GENE

The Non-Coding B2 RNA Binds to the DNA Cleft and Active-Site Region of RNA Polymerase II

(2013) Steven L. Ponicsan et al.   JOURNAL OF MOLECULAR BIOLOGY

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

Ago1 Interacts with RNA Polymerase II and Binds to the Promoters of Actively Transcribed Genes in Human Cancer Cells

(2013) Vera Huang et al.   PLoS Genetics

An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

(2013) Celsa A. Spina et al.   PLoS Pathogens

HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period

(2012) Mie Kobayashi-Ishihara et al.   Retrovirology

CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

(2012) Denitra Breuer et al.   Retrovirology

Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells

(2012) Anupriya Aggarwal et al.   PLoS Pathogens

Impact of treatment with raltegravir during primary or chronic HIV infection on RNA decay characteristics and the HIV viral reservoir

(2011) Kersten K. Koelsch et al.   AIDS

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

(2011) Wendy Bernhard et al.   FEBS LETTERS

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Transcriptional gene silencing of HIV-1 through promoter targeted RNA is highly specific

(2011) Kazuo Suzuki et al.   RNA Biology

Gene-specific RNA polymerase II phosphorylation and the CTD code

(2010) Hyunmin Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

Retroviral delivery of promoter-targeted shRNA induces long-term silencing of HIV-1 transcription

(2009) Makoto Yamagishi et al.   MICROBES AND INFECTION

Closed Chromatin Architecture Is Induced by an RNA Duplex Targeting the HIV-1 Promoter Region

(2008) Kazuo Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY