Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy

(2017) Jenna B Honeycutt et al.   NATURE MEDICINE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder

(2016) Thomas M. Gates et al.   AIDS

Macrophages sustain HIV replication in vivo independently of T cells

(2016) Jenna B. Honeycutt et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation

(2016) Manmeet K. Mamik et al.   Journal of Neuroimmune Pharmacology

Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration

(2016) M. K. Mamik et al.   JOURNAL OF NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing

(2016) Francesc Cunyat et al.   JOURNAL OF VIROLOGY

Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques

(2016) Claudia R. Avalos et al.   JOURNAL OF VIROLOGY

HIV DNA Is Frequently Present within Pathologic Tissues Evaluated at Autopsy from Combined Antiretroviral Therapy-Treated Patients with Undetectable Viral Loads

(2016) Susanna L. Lamers et al.   JOURNAL OF VIROLOGY

Persistent HIV-1 replication maintains the tissue reservoir during therapy

(2016) Ramon Lorenzo-Redondo et al.   NATURE

Defective proviruses rapidly accumulate during acute HIV-1 infection

(2016) Katherine M Bruner et al.   NATURE MEDICINE

CCR5 blockade for neuroinflammatory diseases — beyond control of HIV

(2016) Guillaume Martin-Blondel et al.   Nature Reviews Neurology

HIV-1 cellular and tissue replication patterns in infected humanized mice

(2016) Mariluz Araínga et al.   Scientific Reports

Brain microbiota disruption within inflammatory demyelinating lesions in multiple sclerosis

(2016) W. G. Branton et al.   Scientific Reports

Viral and inflammatory markers in cerebrospinal fluid of patients with HIV-1-associated neurocognitive impairment during antiretroviral treatment switch

(2015) JM Tiraboschi et al.   HIV MEDICINE

Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

(2015) Nathan Osman et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies

(2015) L R Gray et al.   MOLECULAR PSYCHIATRY

Comparison of digital PCR platforms and semi-nested qPCR as a tool to determine the size of the HIV reservoir

(2015) K. J. Bosman et al.   Scientific Reports

Compartmentalized Replication of R5 T Cell-Tropic HIV-1 in the Central Nervous System Early in the Course of Infection

(2015) Christa Buckheit Sturdevant et al.   PLoS Pathogens

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection

(2015) Abderaouf Damouche et al.   PLoS Pathogens

ING116070: A Study of the Pharmacokinetics and Antiviral Activity of Dolutegravir in Cerebrospinal Fluid in HIV-1-Infected, Antiretroviral Therapy-Naive Subjects

(2014) S. L. Letendre et al.   CLINICAL INFECTIOUS DISEASES

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues

(2014) Courtney V. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

(2014) John G Walsh et al.   Retrovirology

CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

(2014) Luca Micci et al.   PLoS Pathogens

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques

(2013) Kathleen M. Kelly et al.   AIDS

High interpatient variability of raltegravir CSF concentrations in HIV-positive patients: a pharmacogenetic analysis

(2013) A. Calcagno et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Etravirine in CSF is highly protein bound

(2013) A. Nguyen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

(2013) E. Pauls et al.   JOURNAL OF IMMUNOLOGY

Brain Microbial Populations in HIV/AIDS: α-Proteobacteria Predominate Independent of Host Immune Status

(2013) William G. Branton et al.   PLoS One

The NRTIs Lamivudine, Stavudine and Zidovudine Have Reduced HIV-1 Inhibitory Activity in Astrocytes

(2013) Lachlan R. Gray et al.   PLoS One

Maraviroc Attenuates Trauma-Hemorrhage-Induced Hepatic Injury through PPAR Gamma-Dependent Pathway in Rats

(2013) Fu-Chao Liu et al.   PLoS One

Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice

(2013) Vibhuti P Dave et al.   Retrovirology

Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

(2012) David Croteau et al.   AIDS

Determinants of darunavir cerebrospinal fluid concentrations

(2012) Andrea Calcagno et al.   AIDS

Predictors of symptomatic HIV-associated neurocognitive disorders in universal health care

(2012) JA McCombe et al.   HIV MEDICINE

Neurovirological Correlation With HIV-Associated Neurocognitive Disorders and Encephalitis in a HAART-Era Cohort

(2012) Benjamin B. Gelman et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Etravirine concentrations in CSF in HIV-infected patients

(2012) J. M. Tiraboschi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

(2012) D. Croteau et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Quantification of Unintegrated HIV-1 DNA at the Single Cell Level In Vivo

(2012) Rodolphe Suspène et al.   PLoS One

Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons

(2012) Viviana Cobos Jiménez et al.   Scientific Reports

Comparative antiviral activity of integrase inhibitors in human monocyte-derived macrophages and lymphocytes

(2011) Fernanda Scopelliti et al.   ANTIVIRAL RESEARCH

Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress

(2011) Ferdinand Maingat et al.   FASEB JOURNAL

Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1

(2010) D. Croteau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Maraviroc Concentrations in Cerebrospinal Fluid in HIV-Infected Patients

(2010) Juan Manuel Tiraboschi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

Neurologic disease burden in treated HIV/AIDS predicts survival: A population-based study

(2010) P. Vivithanaporn et al.   NEUROLOGY

Cerebrospinal fluid maraviroc concentrations in HIV-1 infected patients

(2009) Aylin Yilmaz et al.   AIDS

Raltegravir Cerebrospinal Fluid Concentrations in HIV-1 Infection

(2009) Aylin Yilmaz et al.   PLoS One

A more precise HIV integration assay designed to detect small differences finds lower levels of integrated DNA in HAART treated patients

(2008) Jianqing J. Yu et al.   VIROLOGY