Human pluripotent stem cells for the modelling and treatment of respiratory diseases

Stem Cell-Derived Endothelial Cell Model that Responds to Tobacco Smoke Like Primary Endothelial Cells

(2020) Pei-Hsuan Chu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models

(2020) Jessica L Forbester et al.   JOURNAL OF VIROLOGY

Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway

(2020) Kathrin Haake et al.   Cells

In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells

(2020) Sander van Riet et al.   Scientific Reports

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

(2020) Finn J. Hawkins et al.   Cell Stem Cell

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

(2020) Jessie Huang et al.   Cell Stem Cell

Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

(2020) Emily M. Holloway et al.   DEVELOPMENTAL CELL

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids

(2019) Yohei Korogi et al.   Stem Cell Reports

The potential and limitations of induced pluripotent stem cells to achieve wound healing

(2019) Jolanta Gorecka et al.   Stem Cell Research & Therapy

Human pluripotent stem cell-derived alveolar epithelial cells are alternatives for in vitro pulmotoxicity assessment

(2019) Hye-Ryeon Heo et al.   Scientific Reports

Human pluripotent stem cell-derived mesenchymal stem cells prevent chronic allergic airway inflammation via TGF-β1-Smad2/Smad3 signaling pathway in mice

(2019) Hua Zhong et al.   MOLECULAR IMMUNOLOGY

Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids

(2019) M. Porotto et al.   mBio

High-Throughput Screening for Modulators of CFTR Activity Based on Genetically Engineered Cystic Fibrosis Disease-Specific iPSCs

(2019) Sylvia Merkert et al.   Stem Cell Reports

Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

(2019) Michael Xavier Doss et al.   Cells

The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease

(2019) Lu Zhao et al.   Stem Cell Research & Therapy

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

iPSC-derived MSC therapy induces immune tolerance and supports long-term graft survival in mouse orthotopic tracheal transplants

(2019) Mohammad Afzal Khan et al.   Stem Cell Research & Therapy

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

The immunoregulation of mesenchymal stem cells plays a critical role in improving the prognosis of liver transplantation

(2019) Chenxia Hu et al.   Journal of Translational Medicine

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule

(2019) Preethi Vijayaraj et al.   Cell Reports

Engineered cell and tissue models of pulmonary fibrosis

(2018) Aswin Sundarakrishnan et al.   ADVANCED DRUG DELIVERY REVIEWS

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling

(2018) Fedir N. Kiskin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human induced pluripotent stem cell–derived lung progenitor and alveolar epithelial cells attenuate hyperoxia-induced lung injury

(2018) Mehdi Shafa et al.   CYTOTHERAPY

The genes involved in asthma with the treatment of human embryonic stem cell-derived mesenchymal stem cells

(2018) Yong-Dong Lin et al.   MOLECULAR IMMUNOLOGY

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions

(2018) Pieter S. Hiemstra et al.   TOXICOLOGY IN VITRO

Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes

(2018) Shu-Bin Fang et al.   Stem Cell Research & Therapy

Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells

(2018) Junhao Deng et al.   Stem Cells International

Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials

(2018) Zhongwei Sun et al.   Journal of Thoracic Disease

Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset

(2018) Patty Sachamitr et al.   Frontiers in Immunology

Induced Pluripotent Stem Cells for Primary Ciliary Dyskinesia Modeling and Personalized Medicine

(2018) Joffrey Mianné et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Induced pluripotent stem cells for treating cystic fibrosis: State of the science

(2018) Bette S. Pollard et al.   PEDIATRIC PULMONOLOGY

Building and Regenerating the Lung Cell by Cell

(2018) Jeffrey A. Whitsett et al.   PHYSIOLOGICAL REVIEWS

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections

(2018) Mania Ackermann et al.   Nature Communications

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Stem cell biology and regenerative medicine for neonatal lung diseases

(2017) Martin Kang et al.   PEDIATRIC RESEARCH

In Vitro Models to Study Human Lung Development, Disease and Homeostasis

(2017) Alyssa J. Miller et al.   PHYSIOLOGY

Comparing the cytotoxicity of electronic cigarette fluids, aerosols and solvents

(2017) Rachel Z Behar et al.   TOBACCO CONTROL

Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells

(2017) Wen-Xiang Gao et al.   Stem Cell Research & Therapy

Organoids as a model system for studying human lung development and disease

(2016) Rohan R. Nadkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cells and Culture Systems Used to Model the Small Airway Epithelium

(2016) Rudra Bhowmick et al.   LUNG

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

(2016) Michael J Workman et al.   NATURE MEDICINE

A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema

(2016) J. Stolk et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Mesenchymal stem cells and immunomodulation: current status and future prospects

(2016) F Gao et al.   Cell Death & Disease

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

(2016) Satoshi Konishi et al.   Stem Cell Reports

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells

(2015) Sarah X L Huang et al.   Nature Protocols

Generation of pure lymphatic endothelial cells from human pluripotent stem cells and their therapeutic effects on wound repair

(2015) Shin-Jeong Lee et al.   Scientific Reports

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

(2015) Nico Lachmann et al.   Stem Cell Reports

Respiratory Syncytial Virus Can Infect Basal Cells and Alter Human Airway Epithelial Differentiation

(2014) B. David Persson et al.   PLoS One

Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells

(2014) Joana Frobel et al.   Stem Cell Reports

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

(2013) Hong Yu Ren et al.   MOLECULAR BIOLOGY OF THE CELL

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

(2012) Amy P Wong et al.   NATURE BIOTECHNOLOGY

Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility

(2012) Christine Cheung et al.   NATURE BIOTECHNOLOGY

Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Allergic Airway Inflammation in Mice

(2012) Yue-Qi Sun et al.   STEM CELLS

Small Molecule Mesengenic Induction of Human Induced Pluripotent Stem Cells to Generate Mesenchymal Stem/Stromal Cells

(2012) Yen Shun Chen et al.   Stem Cells Translational Medicine

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb Ischemia in Mice

(2010) Qizhou Lian et al.   CIRCULATION

Transplantation of Human Embryonic Stem Cell–Derived Alveolar Epithelial Type II Cells Abrogates Acute Lung Injury in Mice

(2010) Dachun Wang et al.   MOLECULAR THERAPY

Ciliated epithelial cell lifespan in the mouse trachea and lung

(2008) Emma L. Rawlins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY