The Emerging Mechanisms of Wnt Secretion and Signaling in Development

Quantitative analyses reveal extracellular dynamics of Wnt ligands in Xenopus embryos

(2021) Yusuke Mii et al.   eLife

Glypicans shield the Wnt lipid moiety to enable signalling at a distance

(2020) Ian J. McGough et al.   NATURE

Heparan Sulfate Proteoglycan Clustering in Wnt Signaling and Dispersal

(2020) Yusuke Mii et al.   Frontiers in Cell and Developmental Biology

Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins

(2020) Carl Harrison et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands

(2020) Joyce J.S. Yu et al.   DEVELOPMENTAL CELL

No Evidence that Wnt Ligands Are Required for Planar Cell Polarity in Drosophila

(2020) Ben Ewen-Campen et al.   Cell Reports

Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion

(2020) Rie Nygaard et al.   CELL

Mechanisms of intercellular Wnt transport

(2019) Daniel Routledge et al.   DEVELOPMENT

WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

(2019) Karol Kaiser et al.   Nature Communications

Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization

(2019) Ai Tian et al.   PLoS Genetics

Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing

(2019) Varun Chaudhary et al.   DEVELOPMENT

Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

(2019) Varun Chaudhary et al.   PLoS Genetics

WNT Signaling in Disease

(2019) Ng et al.   Cells

Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

(2019) Menghao Lu et al.   eLife

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt signaling in development and tissue homeostasis

(2018) Zachary Steinhart et al.   DEVELOPMENT

APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway

(2018) Kenyi Saito-Diaz et al.   DEVELOPMENTAL CELL

Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

(2018) Ariel M Pani et al.   eLife

Release and spread of Wingless is required to pattern the proximo-distal axis of Drosophila renal tubules

(2018) Robin Beaven et al.   eLife

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway

(2018) Yue Hua et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in the secretion and transport of Wnt proteins

(2017) Shinji Takada et al.   JOURNAL OF BIOCHEMISTRY

Planar cell polarity in development and disease

(2017) Mitchell T. Butler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

(2017) Yusuke Mii et al.   Nature Communications

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled

(2016) Melissa V. Gammons et al.   MOLECULAR CELL

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs

(2016) Yasuo Yamazaki et al.   NATURE CELL BIOLOGY

Wnt signaling in cancer

(2016) T Zhan et al.   ONCOGENE

Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling inDrosophilawing discs

(2016) Anupama Hemalatha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt proteins can direct planar cell polarity in vertebrate ectoderm

(2016) Chih-Wen Chu et al.   eLife

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Conservation of Planar Polarity Pathway Function Across the Animal Kingdom

(2015) Rosalind Hale et al.   Annual Review of Genetics

Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway

(2015) Xue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

(2015) S. Das et al.   DEVELOPMENT

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

(2015) Hai Huang et al.   eLife

PowerfulDrosophilascreens that paved the wingless pathway

(2015) Fabian Heinz Jenny et al.   FLY

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

(2014) Jia Yu et al.   DEVELOPMENTAL CELL

Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm

(2014) Marta Luz et al.   PLoS One

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Wnt/Catenin Signaling in Adult Stem Cell Physiology and Disease

(2014) Alexander Ring et al.   Stem Cell Reviews and Reports

Secretion and extracellular space travel of Wnt proteins

(2013) Julia Christina Gross et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Perlecan regulates bidirectional Wnt signaling at theDrosophilaneuromuscular junction

(2013) Keisuke Kamimura et al.   JOURNAL OF CELL BIOLOGY

Patterning and growth control by membrane-tethered Wingless

(2013) Cyrille Alexandre et al.   NATURE

Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila

(2013) Jun Wu et al.   NATURE CELL BIOLOGY

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction

(2013) J. Green et al.   Cold Spring Harbor Perspectives in Biology

Live imaging of active fluorophore labelled Wnt proteins

(2012) Tatjana Holzer et al.   FEBS LETTERS

Structure–Function Dissection of the Frizzled Receptor in Drosophila melanogaster Suggests Different Mechanisms of Action in Planar Polarity and Canonical Wnt Signaling

(2012) David Strutt et al.   GENETICS

Mechanism of Evenness Interrupted (Evi)-Exosome Release at Synaptic Boutons

(2012) Kate Koles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

Drosophila S2 Cells Secrete Wingless on Exosome-Like Vesicles but the Wingless Gradient Forms Independently of Exosomes

(2012) Karen Beckett et al.   TRAFFIC

Wnt/Ca2+ signaling pathway: a brief overview

(2011) Antara De   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless

(2011) Peng Zhang et al.   CELL RESEARCH

Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein

(2011) M. Harterink et al.   DEVELOPMENT

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos

(2011) Steffen Biechele et al.   DEVELOPMENTAL BIOLOGY

Porcupine-mediated lipidation is required for Wnt recognition by Wls

(2011) Patrick Herr et al.   DEVELOPMENTAL BIOLOGY

Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2

(2011) Bo Gao et al.   DEVELOPMENTAL CELL

p24 proteins are required for secretion of Wnt ligands

(2011) Tina Buechling et al.   EMBO REPORTS

A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

(2011) Fillip Port et al.   EMBO REPORTS

The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling

(2011) Guillaume A. Castillon et al.   MOLECULAR BIOLOGY OF THE CELL

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome

(2011) J. J. Barrott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regeneration and transdetermination: The role of wingless and its regulation

(2010) Margrit Schubiger et al.   DEVELOPMENTAL BIOLOGY

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

(2010) G. S. Coombs et al.   JOURNAL OF CELL SCIENCE

Interpretation of the Wingless Gradient Requires Signaling-Induced Self-Inhibition

(2009) Eugenia Piddini et al.   CELL

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range

(2009) Y. Mii et al.   DEVELOPMENT

The Core Protein of Glypican Dally-Like Determines Its Biphasic Activity in Wingless Morphogen Signaling

(2009) Dong Yan et al.   DEVELOPMENTAL CELL

Mammalian Wnt3a is Released on Lipoprotein Particles

(2009) Sylvia Neumann et al.   TRAFFIC

Integrating technologies for comparing 3D gene expression domains in the developing chick limb

(2008) Malcolm E. Fisher et al.   DEVELOPMENTAL BIOLOGY

Molecular Integration of Wingless, Decapentaplegic, and Autoregulatory Inputs into Distalless during Drosophila Leg Development

(2008) Carlos Estella et al.   DEVELOPMENTAL CELL

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

(2008) Vladimir L Katanaev et al.   EMBO JOURNAL

WGEF activates Rho in the Wnt–PCP pathway and controls convergent extension in Xenopus gastrulation

(2008) Kosuke Tanegashima et al.   EMBO JOURNAL

Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation

(2008) Sibel Aylin Ugur et al.   HUMAN MOLECULAR GENETICS

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

(2008) Jérôme Gros et al.   NATURE

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL

Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells

(2007) Pei-Tzu Yang et al.   DEVELOPMENTAL CELL

C. elegans AP-2 and Retromer Control Wnt Signaling by Regulating MIG-14/Wntless

(2007) Chun-Liang Pan et al.   DEVELOPMENTAL CELL