Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging

PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment

(2020) Marta Pérez-González et al.   PROGRESS IN NEUROBIOLOGY

Lipidomic and biophysical homeostasis of mammalian membranes counteracts dietary lipid perturbations to maintain cellular fitness

(2020) Kandice R. Levental et al.   Nature Communications

The Atlas of Inflammation Resolution (AIR)

(2020) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity

(2020) Regina F. Fernandez et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction

(2019) Gijs Kooij et al.   HAEMATOLOGICA

Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse

(2019) Benjamin J. Hale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction

(2019) Ekaterina S. Lobanova et al.   JOURNAL OF NEUROSCIENCE

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

(2019) Paraskevi Krashia et al.   Nature Communications

Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice

(2019) Emanuela Talamonti et al.   FASEB JOURNAL

Early treatment with C1 esterase inhibitor improves weight but not memory deficits in a rat model of status epilepticus

(2019) Nicole D. Schartz et al.   PHYSIOLOGY & BEHAVIOR

N- Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid

(2018) Hee-Yong Kim et al.   MOLECULAR ASPECTS OF MEDICINE

Towards targeting resolution pathways of airway inflammation in asthma

(2018) Cindy Barnig et al.   PHARMACOLOGY & THERAPEUTICS

Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation

(2018) Brita Kilburg-Basnyat et al.   TOXICOLOGICAL SCIENCES

Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage

(2018) Marco M Manni et al.   eLife

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

(2018) Alexandre Caron et al.   eLife

Bioactive Lipids and Chronic Inflammation: Managing the Fire Within

(2018) Valerio Chiurchiù et al.   Frontiers in Immunology

The Isoform-Specific Pathological Effects of ApoE4 in vivo are Prevented by a Fish Oil (DHA) Diet and are Modified by Cholesterol

(2018) Zehavit Kariv-Inbal et al.   JOURNAL OF ALZHEIMERS DISEASE

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

(2018) Jia Pei Chan et al.   PLOS BIOLOGY

Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer’s disease

(2018) Rhonda P. Patrick   FASEB JOURNAL

Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain

(2018) Regina F. Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ACSL6 is critical for maintaining brain DHA levels

(2018) Raphaël Chouinard-Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

(2017) Charles N. Serhan   FASEB JOURNAL

Metabolism and functions of docosahexaenoic acid-containing membrane glycerophospholipids

(2017) Daisuke Hishikawa et al.   FEBS LETTERS

Regional changes in CNS and retinal glycerophospholipid profiles with age: a molecular blueprint

(2017) Blake R. Hopiavuori et al.   JOURNAL OF LIPID RESEARCH

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-Analysis of Clinical Trials and Biological Studies

(2017) Jane Pei-Chen Chang et al.   NEUROPSYCHOPHARMACOLOGY

The Reactome Pathway Knowledgebase

(2017) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

PLA2G3, a Gene Involved in Oxidative Stress Induced Death, is Associated with Alzheimer's Disease

(2017) Ana Martínez-García et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipid unsaturation and organelle dynamics

(2016) Hélène Barelli et al.   CURRENT OPINION IN CELL BIOLOGY

The pleiotropic effects of omega-3 docosahexaenoic acid on the hallmarks of Alzheimer's disease

(2016) Mounir Belkouch et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Membrane Lipids in Presynaptic Function and Disease

(2016) Elsa Lauwers et al.   NEURON

Heatmapper: web-enabled heat mapping for all

(2016) Sasha Babicki et al.   NUCLEIC ACIDS RESEARCH

Dietary DHA and health: cognitive function ageing

(2016) Carlos Cardoso et al.   NUTRITION RESEARCH REVIEWS

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

A novel Alzheimer disease locus located near the gene encoding tau protein

(2015) G Jun et al.   MOLECULAR PSYCHIATRY

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Docosahexaenoic acid and human brain development: Evidence that a dietary supply is needed for optimal development

(2014) J. Thomas Brenna et al.   JOURNAL OF HUMAN EVOLUTION

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

U.S. adults are not meeting recommended levels for fish and omega-3 fatty acid intake: results of an analysis using observational data from NHANES 2003–2008

(2014) Yanni Papanikolaou et al.   Nutrition Journal

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

(2014) Matthew D Li et al.   Acta Neuropathologica Communications

Fatty acid analysis by high resolution gas chromatography and mass spectrometry for clinical and experimental applications

(2013) J. Thomas Brenna   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Epoxy Fatty Acids and Inhibition of the Soluble Epoxide Hydrolase Selectively Modulate GABA Mediated Neurotransmission to Delay Onset of Seizures

(2013) Bora Inceoglu et al.   PLoS One

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution

(2012) Michael A. Crawford et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Docosahexaenoic Acid Signalolipidomics in Nutrition: Significance in Aging, Neuroinflammation, Macular Degeneration, Alzheimer's, and Other Neurodegenerative Diseases

(2011) Nicolas G. Bazan et al.   Annual Review of Nutrition

Effects of Docosahexaenoic Acid on Mouse Brain Synaptic Plasma Membrane Proteome Analyzed by Mass Spectrometry and16O/18O Labeling

(2011) Vishaldeep K. Sidhu et al.   JOURNAL OF PROTEOME RESEARCH

Identification of Novel Schizophrenia Loci by Homozygosity Mapping Using DNA Microarray Analysis

(2011) Naohiro Kurotaki et al.   PLoS One

Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain

(2010) Hyung-Wook Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Revisiting Hydrophobic Mismatch with Free Energy Simulation Studies of Transmembrane Helix Tilt and Rotation

(2010) Taehoon Kim et al.   BIOPHYSICAL JOURNAL

Acyl-coenzyme A synthetases in metabolic control

(2010) Jessica M Ellis et al.   CURRENT OPINION IN LIPIDOLOGY

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function

(2009) Dehua Cao et al.   JOURNAL OF NEUROCHEMISTRY

Dietary fish oil n-3 polyunsaturated fatty acids and alpha-linolenic acid differently affect brain accretion of docosahexaenoic acid and expression of desaturases and sterol regulatory element-binding protein 1 in mice☆

(2009) Haiyan Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Genomewide association study for susceptibility genes contributing to familial Parkinson disease

(2008) Nathan Pankratz et al.   HUMAN GENETICS

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Docosahexaenoic Acid and the Aging Brain

(2008) Walter J. Lukiw et al.   JOURNAL OF NUTRITION

The Influence of Maternal Early to Mid-Gestation Nutrient Restriction on Long Chain Polyunsaturated Fatty Acids in Fetal Sheep

(2008) Yunhua Zhou et al.   LIPIDS

Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder

(2008) Robert K. McNamara et al.   PSYCHIATRY RESEARCH