The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain

Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis

(2018) Bo Wang et al.   Cell Stem Cell

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

ER phospholipid composition modulates lipogenesis during feeding and in obesity

(2017) Xin Rong et al.   JOURNAL OF CLINICAL INVESTIGATION

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Cell-Autonomous Control of Neuronal Dendrite Expansion via the Fatty Acid Synthesis Regulator SREBP

(2017) Anna B. Ziegler et al.   Cell Reports

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

(2017) Shunxing Rong et al.   eLife

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet

(2016) Bo Wang et al.   Cell Metabolism

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

How polyunsaturated fatty acids modify molecular organization in membranes: Insight from NMR studies of model systems

(2015) Saame Raza Shaikh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

(2015) Laurent Vergnes et al.   JOURNAL OF LIPID RESEARCH

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

(2015) Vafa Alakbarzade et al.   NATURE GENETICS

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion

(2015) Xin Rong et al.   eLife

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice

(2014) Anna M. Pauter et al.   JOURNAL OF LIPID RESEARCH

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

Isolation and expansion of human and mouse brain microvascular endothelial cells

(2013) Stefania E Navone et al.   Nature Protocols

Reduction of the Cholesterol Sensor SCAP in the Brains of Mice Causes Impaired Synaptic Transmission and Altered Cognitive Function

(2013) Ryo Suzuki et al.   PLOS BIOLOGY

Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism

(2012) Justin H. Berger et al.   PLoS One

Genetic causes of microcephaly and lessons for neuronal development

(2012) Edward C. Gilmore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation

(2011) Harini Sampath et al.   Annals of the New York Academy of Sciences

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy

(2011) Young-Kyo Seo et al.   Cell Metabolism

Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor   in Mouse Liver Reveals Extensive Sharing of Binding Sites

(2011) M. Boergesen et al.   MOLECULAR AND CELLULAR BIOLOGY

Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease

(2011) Giuseppe Astarita et al.   PLoS One

Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) – Implications for dietary recommendations

(2010) Philippe Guesnet et al.   BIOCHIMIE

Lipidomics reveals a remarkable diversity of lipids in human plasma,

(2010) Oswald Quehenberger et al.   JOURNAL OF LIPID RESEARCH

Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

(2010) William J. Zuercher et al.   JOURNAL OF MEDICINAL CHEMISTRY

DHA Deficiency and Prefrontal Cortex Neuropathology in Recurrent Affective Disorders

(2010) Robert K. McNamara   JOURNAL OF NUTRITION

Investigation of postmortem brain polyunsaturated fatty acid composition in psychiatric disorders: Limitations, challenges, and future directions

(2010) Robert K. McNamara et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

Unsaturated Fatty Acids Inhibit Proteasomal Degradation of Insig-1 at a Postubiquitination Step

(2008) Joon No Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice

(2008) Young-Ah Moon et al.   JOURNAL OF LIPID RESEARCH

Lipid rafts, cholesterol, and the brain

(2008) Zeljka Korade et al.   NEUROPHARMACOLOGY

The aging human orbitofrontal cortex: Decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity

(2008) Robert K. McNamara et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS