Integrated longitudinal immunophenotypic, transcriptional, and repertoire analyses delineate immune responses in patients with COVID-19

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

(2021) Jennifer M. Dan et al.   SCIENCE

Durable SARS-CoV-2 B cell immunity after mild or severe disease

(2021) Clinton O. Ogega et al.   JOURNAL OF CLINICAL INVESTIGATION

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

(2021) Jackson S. Turner et al.   NATURE

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

(2021) Zijun Wang et al.   NATURE

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones

(2020) Anastasia A Minervina et al.   eLife

Myeloid cells in sepsis-acquired immunodeficiency

(2020) Fabienne Venet et al.   Annals of the New York Academy of Sciences

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

(2020) Alba Grifoni et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Distinct features of SARS-CoV-2-specific IgA response in COVID-19 patients

(2020) Hai-qiong Yu et al.   EUROPEAN RESPIRATORY JOURNAL

Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

(2020) Ling Ni et al.   IMMUNITY

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

(2020) Giacomo Grasselli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing

(2020) Wen Wen et al.   Cell Discovery

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease

(2020) Christoph Schultheiß et al.   IMMUNITY

Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients

(2020) Linnan Zhu et al.   IMMUNITY

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Single-cell landscape of immunological responses in patients with COVID-19

(2020) Ji-Yuan Zhang et al.   NATURE IMMUNOLOGY

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

(2020) Divij Mathew et al.   SCIENCE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

(2020) Lakshmanane Premkumar et al.   Science Immunology

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity

(2020) Carolyn Rydyznski Moderbacher et al.   CELL

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

(2020) Luca Piccoli et al.   CELL

Expansion of atypical memory B cells is a prominent feature of COVID-19

(2020) Barbara Oliviero et al.   Cellular & Molecular Immunology

Unique immunological profile in patients with COVID-19

(2020) Stefania Varchetta et al.   Cellular & Molecular Immunology

Kinetics of viral load and antibody response in relation to COVID-19 severity

(2020) Yanqun Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

(2020) Yanchun Peng et al.   NATURE IMMUNOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

(2020) Lauren B. Rodda et al.   CELL

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

(2020) Yapeng Su et al.   CELL

Early Phases of COVID-19 Are Characterized by a Reduction in Lymphocyte Populations and the Presence of Atypical Monocytes

(2020) Andrea Lombardi et al.   Frontiers in Immunology

Nonclassical Monocytes in Health and Disease

(2019) Prakash Babu Narasimhan et al.   Annual Review of Immunology

FCRL5+ Memory B Cells Exhibit Robust Recall Responses

(2019) Charles C. Kim et al.   Cell Reports

Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients

(2019) Yuanyuan Zhang et al.   Scientific Data

TCR- or Cytokine-Activated CD8+ Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses

(2019) Rajesh Lamichhane et al.   Cell Reports

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

(2019) Amania A. Sheikh et al.   Cell Reports

Heterogeneity of human bone marrow and blood natural killer cells defined by single-cell transcriptome

(2019) Chao Yang et al.   Nature Communications

CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

(2019) Tomasz Ahrends et al.   Nature Communications

KLRG1 + Effector CD8 + T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

(2018) Dietmar Herndler-Brandstetter et al.   IMMUNITY

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis

(2018) Seong-In Jeong et al.   Cell Death & Disease

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

(2018) Laura M. Snell et al.   IMMUNITY

Emerging insights into human health and NK cell biology from the study of NK cell deficiencies

(2018) Emily M. Mace et al.   IMMUNOLOGICAL REVIEWS

The Broad Spectrum of Human Natural Killer Cell Diversity

(2017) Aharon G. Freud et al.   IMMUNITY

Origin and differentiation of human memory CD8 T cells after vaccination

(2017) Rama S. Akondy et al.   NATURE

The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis

(2016) Carmen Gerlach et al.   IMMUNITY

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

(2016) Ran He et al.   NATURE

CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

(2016) Yew Ann Leong et al.   NATURE IMMUNOLOGY

MAIT cells are activated during human viral infections

(2016) Bonnie van Wilgenburg et al.   Nature Communications

FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure

(2015) Richard T. Sullivan et al.   PLoS Pathogens

T Cell Responses to Whole SARS Coronavirus in Humans

(2014) C. K.-f. Li et al.   JOURNAL OF IMMUNOLOGY

Primary Human Cytomegalovirus Infection Induces the Expansion of Virus-Specific Activated and Atypical Memory B Cells

(2014) Nicolas Dauby et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular regulation of effector and memory T cell differentiation

(2014) John T Chang et al.   NATURE IMMUNOLOGY

B-cell exhaustion in HIV infection

(2014) Susan Moir et al.   Current Opinion in HIV and AIDS

CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages

(2014) Joannah R. Fergusson et al.   Cell Reports

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

(2013) Rangsima Reantragoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MR1 presents microbial vitamin B metabolites to MAIT cells

(2012) Lars Kjer-Nielsen et al.   NATURE

Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells

(2011) C Zhong et al.   CELL DEATH AND DIFFERENTIATION

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study

(2011) F. Tang et al.   JOURNAL OF IMMUNOLOGY

Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

(2010) Kirsten M.L. Hertoghs et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure

(2009) A. Harari et al.   JOURNAL OF VIROLOGY

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

(2008) Surojit Sarkar et al.   JOURNAL OF EXPERIMENTAL MEDICINE