XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis

Identification of XAF1–MT2A mutual antagonism as a molecular switch in cell-fate decisions under stressful conditions

(2017) Cheol-Hee Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA

(2016) Yumiko Komatsu et al.   PLoS One

The regulation role of interferon regulatory factor-1 gene and clinical relevance

(2014) Lei Dou et al.   HUMAN IMMUNOLOGY

Oncogenic Ras inhibits IRF1 to promote viral oncolysis

(2014) Y Komatsu et al.   ONCOGENE

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

(2014) M.-G. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21WAF1

(2013) J Han et al.   CELL DEATH AND DIFFERENTIATION

Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade

(2013) Jennifer Vandooren et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Inhibition of Histone Deacetylase Activity Suppresses IFN-  Induction of Tripartite Motif 22 via CHIP-Mediated Proteasomal Degradation of IRF-1

(2013) B. Gao et al.   JOURNAL OF IMMUNOLOGY

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

(2013) Andrea Lunardi et al.   NATURE GENETICS

Domain organization of XAF1 and the identification and characterization of XIAPRING-binding domain of XAF1

(2012) Man Kit Tse et al.   PROTEIN SCIENCE

Function and mechanism by which interferon regulatory factor-1 inhibits oncogenesis

(2012) FEI-FEI CHEN et al.   Oncology Letters

Tumor suppressor XIAP-Associated factor 1 (XAF1) cooperates with tumor necrosis factor-related apoptosis-inducing ligand to suppress colon cancer growth and trigger tumor regression

(2010) Shui Ping Tu et al.   CANCER

Docking-dependent Ubiquitination of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by the Ubiquitin Ligase CHIP

(2010) Vikram Narayan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of XAF1 as a novel cell cycle regulator through modulating G2/M checkpoint and interaction with checkpoint kinase 1 in gastrointestinal cancer

(2009) J. Wang et al.   CARCINOGENESIS

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

(2009) J Gao et al.   CELL DEATH AND DIFFERENTIATION

c-Jun N-terminal kinase (JNK1) upregulates XIAP-associated factor 1 (XAF1) through interferon regulatory factor 1 (IRF-1) in gastrointestinal cancer

(2008) J. Wang et al.   CARCINOGENESIS