Extracellular vesicles in the development of organ‐specific metastasis

Exosomes Derived from Brain Metastatic Breast Cancer Cells Destroy the Blood-Brain Barrier by Carrying lncRNA GS1-600G8.5

(2020) Yunhe Lu et al.   Biomed Research International

Extracellular microvesicles/exosomes: discovery, disbelief, acceptance, and the future?

(2020) Mariusz Z. Ratajczak et al.   LEUKEMIA

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis

(2019) Stefania Raimondo et al.   Journal of Hematology & Oncology

Extracellular vesicle-associated procoagulant phospholipid and tissue factor activity in multiple myeloma

(2019) Thøger Nielsen et al.   PLoS One

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes

(2019) Bo Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

(2019) Vincent Hyenne et al.   DEVELOPMENTAL CELL

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Brainwashed by extracellular vesicles: the role of extracellular vesicles in primary and metastatic brain tumour microenvironment

(2019) Golnaz Morad et al.   Journal of Extracellular Vesicles

Immune Microenvironment of Brain Metastases—Are Microglia and Other Brain Macrophages Little Helpers?

(2019) Hua You et al.   Frontiers in Immunology

Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis

(2019) Gonçalo Rodrigues et al.   NATURE CELL BIOLOGY

Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells

(2019) Maria Harmati et al.   Scientific Reports

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

(2019) Changhao Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis

(2018) Fei Xing et al.   CANCER RESEARCH

Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis

(2018) Min Li et al.   GENE

Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins

(2018) Jian-Hong Fang et al.   HEPATOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosome-mediated transfer of lncRUNX2-AS1 from multiple myeloma cells to MSCs contributes to osteogenesis

(2018) Bingzong Li et al.   ONCOGENE

Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer

(2018) Qihan Fu et al.   ONCOGENE

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

(2018) Kyoko Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis

(2018) Yingkuan Shao et al.   CARCINOGENESIS

Brain microvascular endothelial cell exosome–mediated S100A16 up-regulation confers small-cell lung cancer cell survival in brain

(2018) Zhi-Hua Xu et al.   FASEB JOURNAL

CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis

(2018) Susanne Pfeiler et al.   FASEB JOURNAL

Coupling of bone resorption and formation by RANKL reverse signalling

(2018) Yuki Ikebuchi et al.   NATURE

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

(2018) Chen-Fei Zhou et al.   ONCOGENE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts

(2018) Sylvia Faict et al.   Blood Cancer Journal

Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential

(2017) Lahiru Gangoda et al.   PROTEOMICS

Disassembly of the Dying: Mechanisms and Functions

(2017) Georgia K. Atkin-Smith et al.   TRENDS IN CELL BIOLOGY

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

(2017) Haiyang Zhang et al.   Nature Communications

Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis

(2017) Yin Ji Piao et al.   Oncotarget

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

(2017) Simona Taverna et al.   Scientific Reports

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Mesenchymal Stem Cell–Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow

(2016) Sarah A. Bliss et al.   CANCER RESEARCH

Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches

(2016) P. Brodt   CLINICAL CANCER RESEARCH

Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis

(2016) Sayantan Maji et al.   MOLECULAR CANCER RESEARCH

Blood–brain Barrier Remodeling during Brain Metastasis Formation

(2016) Jagoda K Wrobel et al.   MOLECULAR MEDICINE

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mechanisms and functions of extracellular vesicle release in vivo—What we can learn from flies and worms

(2016) Katharina B. Beer et al.   Cell Adhesion & Migration

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis

(2015) Miranda Y. Fong et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Investigation of the roles of exosomes in colorectal cancer liver metastasis

(2015) XIA WANG et al.   ONCOLOGY REPORTS

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

(2015) Maria Rita Pitari et al.   Oncotarget

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

(2015) Lavinia Raimondi et al.   Oncotarget

The landscape of metastatic progression patterns across major human cancers

(2015) Jan Budczies et al.   Oncotarget

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8+ T Cells: Mechanism of Immune Evasion

(2014) Marie Lundholm et al.   PLoS One

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells

(2014) M. Ono et al.   Science Signaling

Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

(2014) Amy Chow et al.   Scientific Reports

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Differential Post-Surgical Metastasis and Survival in SCID, NOD-SCID and NOD-SCID-IL-2Rγnull Mice with Parental and Subline Variants of Human Breast Cancer: Implications for Host Defense Mechanisms Regulating Metastasis

(2013) Chloe C. Milsom et al.   PLoS One

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

(2013) P. Kucharzewska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes in Prostate Cancer: Putting Together the Pieces of a Puzzle

(2013) Carolina Soekmadji et al.   Cancers

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination

(2012) M. Labelle et al.   Cancer Discovery

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Proteomic Discovery of Genistein Action in the Rat Mammary Gland

(2011) Jun Wang et al.   JOURNAL OF PROTEOME RESEARCH

The biology of brain metastases—translation to new therapies

(2011) April F. Eichler et al.   Nature Reviews Clinical Oncology

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Endogenous Angiogenesis Inhibitor Vasohibin1 Exhibits Broad-Spectrum Antilymphangiogenic Activity and Suppresses Lymph Node Metastasis

(2010) Takahiro Heishi et al.   AMERICAN JOURNAL OF PATHOLOGY

Natural Killer Cell Cytotoxicity Is Suppressed by Exposure to the Human NKG2D Ligand MICA*008 That Is Shed by Tumor Cells in Exosomes

(2010) O. Ashiru et al.   CANCER RESEARCH

Modeling metastasis in the mouse

(2010) Paula D Bos et al.   CURRENT OPINION IN PHARMACOLOGY

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Tyrosine phosphorylation of annexin A2 regulates Rho-mediated actin rearrangement and cell adhesion

(2008) U. Rescher et al.   JOURNAL OF CELL SCIENCE