Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

(2020) Song Ih Ahn et al.   Nature Communications

Aligned Brain Extracellular Matrix Promotes Differentiation and Myelination of Human-Induced Pluripotent Stem Cell-Derived Oligodendrocytes

(2019) Ann-Na Cho et al.   ACS Applied Materials & Interfaces

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

(2019) Rémi Porte et al.   Frontiers in Immunology

The Early Innate Immune Response to, and Phagocyte-Dependent Entry of, Cryptococcus neoformans Map to the Perivascular Space of Cortical Post-Capillary Venules in Neurocryptococcosis

(2018) Keren Kaufman-Francis et al.   AMERICAN JOURNAL OF PATHOLOGY

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

(2018) Yoonhee Jin et al.   Nature Biomedical Engineering

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

(2017) Radha Rajasingham et al.   LANCET INFECTIOUS DISEASES

Trojan Horse Transit Contributes to Blood-Brain Barrier Crossing of a Eukaryotic Pathogen

(2017) Felipe H. Santiago-Tirado et al.   mBio

Catechol-Functionalized Hyaluronic Acid Hydrogels Enhance Angiogenesis and Osteogenesis of Human Adipose-Derived Stem Cells in Critical Tissue Defects

(2016) Hyun-Ji Park et al.   BIOMACROMOLECULES

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

(2016) Jacquelyn A. Brown et al.   Journal of Neuroinflammation

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

(2016) Akihiro Shindo et al.   STROKE

Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

(2016) Qi Gao et al.   Cell Death & Disease

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

(2016) Kyung-Tae Lee et al.   Nature Communications

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Tissue Adhesive Catechol-Modified Hyaluronic Acid Hydrogel for Effective, Minimally Invasive Cell Therapy

(2015) Jisoo Shin et al.   ADVANCED FUNCTIONAL MATERIALS

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

(2015) Mathieu Odijk et al.   LAB ON A CHIP

Cryptococcus: from environmental saprophyte to global pathogen

(2015) Robin C. May et al.   NATURE REVIEWS MICROBIOLOGY

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

(2015) Kwang-Woo Jung et al.   Nature Communications

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

(2015) Nobuaki Maeda   Frontiers in Neuroscience

Invasion of the Central Nervous System by Cryptococcus neoformans Requires a Secreted Fungal Metalloprotease

(2014) K. Vu et al.   mBio

Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix

(2014) Yoojin Shin et al.   Advanced Healthcare Materials

A microfluidic array for quantitative analysis of human neural stem cell self-renewal and differentiation in three-dimensional hypoxic microenvironment

(2013) Kisuk Yang et al.   BIOMATERIALS

Cryptococcus neoformans Promotes Its Transmigration into the Central Nervous System by Inducing Molecular and Cellular Changes in Brain Endothelial Cells

(2013) Kiem Vu et al.   INFECTION AND IMMUNITY

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

(2013) Tong-Bao Liu et al.   PLoS Pathogens

Matrix composition regulates three-dimensional network formation by endothelial cells and mesenchymal stem cells in collagen/fibrin materials

(2012) Rameshwar R. Rao et al.   ANGIOGENESIS

Polydopamine-mediated surface modification of scaffold materials for human neural stem cell engineering

(2012) Kisuk Yang et al.   BIOMATERIALS

Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

(2012) Ju Hun Yeon et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Mechanisms of infection by the human fungal pathogenCryptococcus neoformans

(2012) Wilber Sabiiti et al.   Future Microbiology

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

Endogenous Thrombospondin-1 Regulates Leukocyte Recruitment and Activation and Accelerates Death from Systemic Candidiasis

(2012) Gema Martin-Manso et al.   PLoS One

The Primary Target Organ of Cryptococcus gattii Is Different from That of Cryptococcus neoformans in a Murine Model

(2012) P. Ngamskulrungroj et al.   mBio

Cryptococcus and Beyond—Inositol Utilization and Its Implications for the Emergence of Fungal Virulence

(2012) Chaoyang Xue   PLoS Pathogens

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

The effect of matrix characteristics on fibroblast proliferation in 3D gels

(2010) Katrin Bott et al.   BIOMATERIALS

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain

(2010) Meiqing Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Autocrine and paracrine up-regulation of blood–brain barrier function by plasminogen activator inhibitor-1

(2010) Shinya Dohgu et al.   MICROVASCULAR RESEARCH

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

In vivo mapping of brain myo-inositol

(2010) Mohammad Haris et al.   NEUROIMAGE

Vascular regression and survival are differentially regulated by MT1-MMP and TIMPs in the aortic ring model of angiogenesis

(2009) A. C. Aplin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection byCryptococcus neoformans

(2009) Kiem Vu et al.   EUKARYOTIC CELL

The blood-brain barrier in neurodegenerative disease: a rhetorical perspective

(2009) Paul M. Carvey et al.   JOURNAL OF NEUROCHEMISTRY

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

(2009) Jianbo Shao et al.   LAB ON A CHIP

Surface-Associated Plasminogen Binding of Cryptococcus neoformans Promotes Extracellular Matrix Invasion

(2009) Jamal Stie et al.   PLoS One

Facile Conjugation of Biomolecules onto Surfaces via Mussel Adhesive Protein Inspired Coatings

(2008) Haeshin Lee et al.   ADVANCED MATERIALS

Predicting functional transcription factor binding through alignment-free and affinity-based analysis of orthologous promoter sequences

(2008) Lucas D. Ward et al.   BIOINFORMATICS

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY

Endothelin-1 Regulates Astrocyte Proliferation and Reactive Gliosis via a JNK/c-Jun Signaling Pathway

(2008) A. Gadea et al.   JOURNAL OF NEUROSCIENCE