Cryptococcus: from environmental saprophyte to global pathogen

Aging as an emergent factor that contributes to phenotypic variation in Cryptococcus neoformans

(2015) Tejas Bouklas et al.   FUNGAL GENETICS AND BIOLOGY

Epidemiology of Cryptococcus and cryptococcosis in China

(2015) Wei Fang et al.   FUNGAL GENETICS AND BIOLOGY

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

(2015) Ferry Hagen et al.   FUNGAL GENETICS AND BIOLOGY

Cryptococcal Phospholipase B1 Is Required for Intracellular Proliferation and Control of Titan Cell Morphology during Macrophage Infection

(2015) Robert J. Evans et al.   INFECTION AND IMMUNITY

Cryptococcus neoformans–Induced Macrophage Lysosome Damage Crucially Contributes to Fungal Virulence

(2015) Michael J. Davis et al.   JOURNAL OF IMMUNOLOGY

Cryptococcal meningitis screening and community-based early adherence support in people with advanced HIV infection starting antiretroviral therapy in Tanzania and Zambia: an open-label, randomised controlled trial

(2015) Sayoki Mfinanga et al.   LANCET

Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts

(2015) Jianfeng Lin et al.   MEDICAL MYCOLOGY

Cryptococcus neoformans Host Adaptation: Toward Biological Evidence of Dormancy

(2015) Alexandre Alanio et al.   mBio

Polyploid Titan Cells Produce Haploid and Aneuploid Progeny To Promote Stress Adaptation

(2015) Aleeza C. Gerstein et al.   mBio

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa

(2015) Mathew A. Beale et al.   PLoS Neglected Tropical Diseases

Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection

(2015) Darin L. Wiesner et al.   PLoS Pathogens

Cerebrospinal Fluid Cytokine Profiles Predict Risk of Early Mortality and Immune Reconstitution Inflammatory Syndrome in HIV-Associated Cryptococcal Meningitis

(2015) Joseph N. Jarvis et al.   PLoS Pathogens

Unraveling the Biology of a Fungal Meningitis Pathogen Using Chemical Genetics

(2014) Jessica C.S. Brown et al.   CELL

Molecular Diagnosis of Central Nervous System Opportunistic Infections in HIV-Infected Zambian Adults

(2014) O. K. Siddiqi et al.   CLINICAL INFECTIOUS DISEASES

CD4+FoxP3+regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection

(2014) Bianca Schulze et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cryptococcus neoformans glucuronoxylomannan fractions of different molecular masses are functionally distinct

(2014) Priscila C Albuquerque et al.   Future Microbiology

Cryptococcus gattii Infection Dampens Th1 and Th17 Responses by Attenuating Dendritic Cell Function and Pulmonary Chemokine Expression in the Immunocompetent Hosts

(2014) Pornpimon Angkasekwinai et al.   INFECTION AND IMMUNITY

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

(2014) Wilber Sabiiti et al.   JOURNAL OF CLINICAL INVESTIGATION

Amphotericin forms an extramembranous and fungicidal sterol sponge

(2014) Thomas M Anderson et al.   Nature Chemical Biology

Timing of Antiretroviral Therapy after Diagnosis of Cryptococcal Meningitis

(2014) David R. Boulware et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-4 Receptor-Alpha-Dependent Control of Cryptococcus neoformans in the Early Phase of Pulmonary Infection

(2014) Andreas Grahnert et al.   PLoS One

Quorum Sensing-Mediated, Cell Density-Dependent Regulation of Growth and Virulence in Cryptococcus neoformans

(2014) P. Albuquerque et al.   mBio

Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies Are a Risk Factor for Central Nervous System Infection by Cryptococcus gattii in Otherwise Immunocompetent Patients

(2014) T. Saijo et al.   mBio

Highly Recombinant VGII Cryptococcus gattii Population Develops Clonal Outbreak Clusters through both Sexual Macroevolution and Asexual Microevolution

(2014) R. B. Billmyre et al.   mBio

Cryptococcus gattii in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal

(2014) D. M. Engelthaler et al.   mBio

Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo

(2014) A. Butts et al.   mBio

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

(2014) Kerstin Voelz et al.   Nature Communications

Cryptococcus gattii VGIII Isolates Causing Infections in HIV/AIDS Patients in Southern California: Identification of the Local Environmental Source as Arboreal

(2014) Deborah J. Springer et al.   PLoS Pathogens

A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions

(2013) Seameen J. Dehdashti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The Intracellular Life of Cryptococcus neoformans

(2013) Carolina Coelho et al.   Annual Review of Pathology-Mechanisms of Disease

Azole Heteroresistance in Cryptococcus neoformans: Emergence of Resistant Clones with Chromosomal Disomy in the Mouse Brain during Fluconazole Treatment

(2013) Edward Sionov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Susceptibility of Intact Germinating Arabidopsis thaliana to Human Fungal Pathogens Cryptococcus neoformans and C. gattii

(2013) Katherine M. Warpeha et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Titan cells in Cryptococcus neoformans: cells with a giant impact

(2013) Oscar Zaragoza et al.   CURRENT OPINION IN MICROBIOLOGY

Interleukin-17A Enhances Host Defense against Cryptococcal Lung Infection through Effects Mediated by Leukocyte Recruitment, Activation, and Gamma Interferon Production

(2013) Benjamin J. Murdock et al.   INFECTION AND IMMUNITY

Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing Th2 response

(2013) Uwe Müller et al.   INTERNATIONAL IMMUNOLOGY

IL-33 Signaling Regulates Innate and Adaptive Immunity to Cryptococcus neoformans

(2013) A. Flaczyk et al.   JOURNAL OF IMMUNOLOGY

Cryptococcosis-IRIS is Associated With Lower Cryptococcus-specific IFN-γ Responses Before Antiretroviral Therapy but Not Higher T-Cell Responses During Therapy

(2013) Christina C. Chang et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcus neoformans Ex Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis

(2013) Emma J. Robertson et al.   JOURNAL OF INFECTIOUS DISEASES

Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries

(2013) Angela Loyse et al.   LANCET INFECTIOUS DISEASES

Combination Antifungal Therapy for Cryptococcal Meningitis

(2013) Jeremy N. Day et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predictors of Mortality and Differences in Clinical Features among Patients with Cryptococcosis According to Immune Status

(2013) Kyle D. Brizendine et al.   PLoS One

Cryptococcus gattii Induces a Cytokine Pattern That Is Distinct from Other Cryptococcal Species

(2013) Teske Schoffelen et al.   PLoS One

Geographically Structured Populations of Cryptococcus neoformans Variety grubii in Asia Correlate with HIV Status and Show a Clonal Population Structure

(2013) Kantarawee Khayhan et al.   PLoS One

Development of an Aerosol Model of Cryptococcus Reveals Humidity as an Important Factor Affecting the Viability of Cryptococcus during Aerosolization

(2013) Deborah J. Springer et al.   PLoS One

Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest

(2013) Ferry Hagen et al.   PLoS One

Fungal adhesion protein guides community behaviors and autoinduction in a paracrine manner

(2013) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Old Cryptococcus neoformans Cells Contribute to Virulence in Chronic Cryptococcosis

(2013) T. Bouklas et al.   mBio

Fc Gamma Receptor 3A Polymorphism and Risk for HIV-Associated Cryptococcal Disease

(2013) S. Rohatgi et al.   mBio

Macrophage M1/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection

(2013) M. J. Davis et al.   mBio

Fungicidal Drugs Induce a Common Oxidative-Damage Cellular Death Pathway

(2013) Peter Belenky et al.   Cell Reports

Unisexual and Heterosexual Meiotic Reproduction Generate Aneuploidy and Phenotypic Diversity De Novo in the Yeast Cryptococcus neoformans

(2013) Min Ni et al.   PLOS BIOLOGY

Brain Inositol Is a Novel Stimulator for Promoting Cryptococcus Penetration of the Blood-Brain Barrier

(2013) Tong-Bao Liu et al.   PLoS Pathogens

Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis

(2012) Joseph N. Jarvis et al.   AIDS

IL-23 Dampens the Allergic Response to Cryptococcus neoformans through IL-17–Independent and –Dependent Mechanisms

(2012) Wendy A. Szymczak et al.   AMERICAN JOURNAL OF PATHOLOGY

T-2307 Causes Collapse of Mitochondrial Membrane Potential in Yeast

(2012) Tatsuya Shibata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections

(2012) Bing Zhai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cryptococcus

(2012) Tami McDonald et al.   CURRENT BIOLOGY

A Repurposing Approach Identifies Off-Patent Drugs with Fungicidal Cryptococcal Activity, a Common Structural Chemotype, and Pharmacological Properties Relevant to the Treatment of Cryptococcosis

(2012) Arielle Butts et al.   EUKARYOTIC CELL

Titan Cells Confer Protection from Phagocytosis in Cryptococcus neoformans Infections

(2012) Laura H. Okagaki et al.   EUKARYOTIC CELL

A Purified Capsular Polysaccharide Markedly Inhibits Inflammatory Response during Endotoxic Shock

(2012) M. Piccioni et al.   INFECTION AND IMMUNITY

Protective Immunity against Pulmonary Cryptococcosis Is Associated with STAT1-Mediated Classical Macrophage Activation

(2012) S. E. Hardison et al.   JOURNAL OF IMMUNOLOGY

Association of Fcγ Receptor IIB Polymorphism with Cryptococcal Meningitis in HIV-Uninfected Chinese Patients

(2012) Xiu-Ping Hu et al.   PLoS One

Immune Modulation Mediated by Cryptococcal Laccase Promotes Pulmonary Growth and Brain Dissemination of Virulent Cryptococcus neoformans in Mice

(2012) Yafeng Qiu et al.   PLoS One

Amphotericin primarily kills yeast by simply binding ergosterol

(2012) K. C. Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptococcal Genotype Influences Immunologic Response and Human Clinical Outcome after Meningitis

(2012) D. L. Wiesner et al.   mBio

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

(2012) Linqi Wang et al.   PLoS Pathogens

DNA Mutations Mediate Microevolution between Host-Adapted Forms of the Pathogenic Fungus Cryptococcus neoformans

(2012) Denise A. Magditch et al.   PLoS Pathogens

Population Genetic Analyses Reveal the African Origin and Strain Variation of Cryptococcus neoformans var. grubii

(2012) Anastasia P. Litvintseva et al.   PLoS Pathogens

In VitroActivity of E1210, a Novel Antifungal, against Clinically Important Yeasts and Molds

(2011) Mamiko Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transmission of Cryptococcus neoformans by Organ Transplantation

(2011) J. W. Baddley et al.   CLINICAL INFECTIOUS DISEASES

Cryptococcus gattii in the United States: Clinical Aspects of Infection With an Emerging Pathogen

(2011) J. R. Harris et al.   CLINICAL INFECTIOUS DISEASES

Evaluation of a Novel Point-of-Care Cryptococcal Antigen Test on Serum, Plasma, and Urine From Patients With HIV-Associated Cryptococcal Meningitis

(2011) J. N. Jarvis et al.   CLINICAL INFECTIOUS DISEASES

Environmental prevalence ofCryptococcus neoformansandCryptococcus gattiiin India: An update

(2011) Anuradha Chowdhary et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Genotypes Coding for Mannose-Binding Lectin Deficiency Correlated With Cryptococcal Meningitis in HIV-Uninfected Chinese Patients

(2011) X.-T. Ou et al.   JOURNAL OF INFECTIOUS DISEASES

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

(2011) James W. Kronstad et al.   NATURE REVIEWS MICROBIOLOGY

Evidence that the Human Pathogenic Fungus Cryptococcus neoformans var. grubii May Have Evolved in Africa

(2011) Anastasia P. Litvintseva et al.   PLoS One

Nonlytic Exocytosis of Cryptococcus neoformans from Macrophages Occurs In Vivo and Is Influenced by Phagosomal pH

(2011) A. M. Nicola et al.   mBio

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

(2010) John R. Perfect et al.   CLINICAL INFECTIOUS DISEASES

Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain

(2010) Meiqing Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation

(2010) Simon A. Johnston et al.   PLoS Pathogens

Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes

(2010) Edward Sionov et al.   PLoS Pathogens

Cryptococcal Cell Morphology Affects Host Cell Interactions and Pathogenicity

(2010) Laura H. Okagaki et al.   PLoS Pathogens

Fungal Cell Gigantism during Mammalian Infection

(2010) Oscar Zaragoza et al.   PLoS Pathogens

Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence

(2009) E. Sionov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation and Characterization of SenescentCryptococcus neoformansand Implications for Phenotypic Switching and Pathogenesis in Chronic Cryptococcosis

(2009) Neena Jain et al.   EUKARYOTIC CELL

Phylogeny and Phenotypic Characterization of PathogenicCryptococcusSpecies and Closely Related Saprobic Taxa in the Tremellales

(2009) Keisha Findley et al.   EUKARYOTIC CELL

Most Environmental Isolates of Cryptococcus neoformans var. grubii (Serotype A) Are Not Lethal for Mice

(2009) A. P. Litvintseva et al.   INFECTION AND IMMUNITY

Elucidating the Pathogenesis of Spores from the Human Fungal Pathogen Cryptococcus neoformans

(2009) S. S. Giles et al.   INFECTION AND IMMUNITY

Spores as Infectious Propagules of Cryptococcus neoformans

(2009) R. Velagapudi et al.   INFECTION AND IMMUNITY

Cytokine Signaling Regulates the Outcome of Intracellular Macrophage Parasitism by Cryptococcus neoformans

(2009) K. Voelz et al.   INFECTION AND IMMUNITY

The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation

(2009) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diploids in the Cryptococcus neoformans Serotype A Population Homozygous for the α Mating Type Originate via Unisexual Mating

(2009) Xiaorong Lin et al.   PLoS Pathogens

Evolution of Intracellular Pathogens

(2008) Arturo Casadevall   Annual Review of Microbiology

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells

(2008) Ambrose Jong et al.   CELLULAR MICROBIOLOGY

Invasion ofCryptococcus neoformansinto human brain microvascular endothelial cells requires protein kinase C-α activation

(2008) Ambrose Jong et al.   CELLULAR MICROBIOLOGY

Capsule enlargement inCryptococcus neoformansconfers resistance to oxidative stress suggesting a mechanism for intracellular survival

(2008) Oscar Zaragoza et al.   CELLULAR MICROBIOLOGY

Inheritance of Immune Polarization Patterns Is Linked to Resistance versus Susceptibility to Cryptococcus neoformans in a Mouse Model

(2008) G.-h. Chen et al.   INFECTION AND IMMUNITY

Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans

(2008) C. Charlier et al.   INFECTION AND IMMUNITY

The role of laccase in prostaglandin production byCryptococcus neoformans

(2008) John R. Erb-Downward et al.   MOLECULAR MICROBIOLOGY

Intracellular pathogenic bacteria and fungi — a case of convergent evolution?

(2008) James B. Bliska et al.   NATURE REVIEWS MICROBIOLOGY