The Uniqueness of Clear Cell Renal Cell Carcinoma: Summary of the Process and Abnormality of Glucose Metabolism and Lipid Metabolism in ccRCC

Targeting ACSS2 with a transition state mimetic inhibits triple-negative breast cancer growth

(2021) Katelyn D. Miller et al.   CANCER RESEARCH

Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity

(2021) Ke Xu et al.   SCIENCE

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

(2021) Yoshikazu Johmura et al.   SCIENCE

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma

(2021) Yongmei Feng et al.   MOLECULAR CANCER THERAPEUTICS

Cell-programmed nutrient partitioning in the tumour microenvironment

(2021) Bradley I. Reinfeld et al.   NATURE

Improving understanding of the obesity paradox in ccRCC

(2020) Louise Stone   Nature Reviews Urology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?

(2020) Aviad Ben-Shmuel et al.   Frontiers in Immunology

Acetate promotes SNAI1 expression by ACSS2-mediated histone acetylation under glucose limitation in renal cell carcinoma cell

(2020) Lv Yao et al.   BIOSCIENCE REPORTS

Structural basis for catalysis and substrate specificity of human ACAT1

(2020) Hongwu Qian et al.   NATURE

PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA

(2020) Liang Shi et al.   OncoTargets and Therapy

A new survival model based on ferroptosis-related genes for prognostic prediction in clear cell renal cell carcinoma

(2020) Guangzhen Wu et al.   Aging-US

The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy

(2020) Yuechen Zhao et al.   OncoTargets and Therapy

Flavonoids against the Warburg phenotype—concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism

(2020) Marek Samec et al.   EPMA Journal

Genetically Encoded Tools for Research of Cell Signaling and Metabolism under Brain Hypoxia

(2020) Alexander I. Kostyuk et al.   Antioxidants

SnapShot: FABP Functions

(2020) Bing Li et al.   CELL

Patent landscape for discovery of promising acyltransferase DGAT and MGAT inhibitors

(2020) Vishal P. Zambre et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

(2020) Rouven Hoefflin et al.   Nature Communications

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

(2020) Linyuan Xue et al.   Frontiers in Oncology

Metabolomic Analysis to Elucidate Mechanisms of Sunitinib Resistance in Renal Cell Carcinoma

(2020) Tomonori Sato et al.   Metabolites

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer

(2019) Seher Balaban et al.   MOLECULAR CANCER RESEARCH

RBCK1 promotes p53 degradation via ubiquitination in renal cell carcinoma

(2019) Sifan Yu et al.   Cell Death & Disease

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

(2019) Peter Vaupel et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Circulating obesity-driven biomarkers are associated with risk of clear cell renal cell carcinoma: a two-stage, case-control study

(2019) Qinchuan Wang et al.   CARCINOGENESIS

Metabolomic insights into pathophysiological mechanisms and biomarker discovery in clear cell renal cell carcinoma

(2019) Giuseppe Lucarelli et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Autophagy, anoikis, ferroptosis, necroptosis, and endoplasmic reticulum stress: Potential applications in melanoma therapy

(2019) Milad Ashrafizadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

(2019) Jia Wei et al.   NATURE

Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?

(2019) Guangzhen Wu et al.   Cell Death & Disease

Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway

(2019) Ge Liu et al.   FASEB JOURNAL

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies

(2019) Xiao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications

(2019) W. Marston Linehan et al.   Nature Reviews Urology

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma

(2019) Guangzhen Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ACAT1 and Metabolism-Related Pathways Are Essential for the Progression of Clear Cell Renal Cell Carcinoma (ccRCC), as Determined by Co-expression Network Analysis

(2019) Liang Chen et al.   Frontiers in Oncology

GPX1, a biomarker for the diagnosis and prognosis of kidney cancer, promotes the progression of kidney cancer

(2019) Yongbiao Cheng et al.   Aging-US

ATP citrate lyase: A central metabolic enzyme in cancer

(2019) Philippe Icard et al.   CANCER LETTERS

A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells

(2019) Hee Chan Yoo et al.   Cell Metabolism

Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma

(2019) Johannes C. van der Mijn et al.   Translational Oncology

Dysregulation of Ketone Body Metabolism Is Associated With Poor Prognosis for Clear Cell Renal Cell Carcinoma Patients

(2019) Wanmeng Cui et al.   Frontiers in Oncology

Lipid metabolism and lipophagy in cancer

(2018) Meenu Maan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

(2018) Maria Buchsteiner et al.   BIOTECHNOLOGY AND BIOENGINEERING

The Plausibility of Obesity Paradox in Cancer—Point

(2018) Yikyung Park et al.   CANCER RESEARCH

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression

(2018) Lv Yao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Four new compounds isolated from Psoralea corylifolia and their diacylglycerol acyltransferase (DGAT) inhibitory activity

(2018) Xin Lin et al.   FITOTERAPIA

The role of hypoxia-inducible factor-2 alpha in angiogenesis

(2018) Christina Befani et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting the mevalonate pathway suppresses VHL-deficient CC-RCC through a HIF-dependent mechanism

(2018) Jordan M. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation

(2018) Jong-Ho Lee et al.   MOLECULAR CELL

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

(2018) Heike Miess et al.   ONCOGENE

Metabolomics and Metabolic Reprogramming in Kidney Cancer

(2018) Robert H. Weiss   SEMINARS IN NEPHROLOGY

Acetyl-CoA synthetase 2 enhances tumorigenesis and is indicative of a poor prognosis for patients with renal cell carcinoma

(2018) Shaojin Zhang et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Role of DGAT enzymes in triacylglycerol metabolism

(2018) Bhumika Bhatt-Wessel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

(2018) James S.V. Lally et al.   Cell Metabolism

Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

(2018) Kevin D. Courtney et al.   Cell Metabolism

Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis

(2018) Seher Balaban et al.   Molecular Oncology

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism

(2018) Zhiguang Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

AMPK: Regulation of Metabolic Dynamics in the Context of Autophagy

(2018) Isaac Tamargo-Gómez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D growth of cancer cells elicits sensitivity to kinase inhibitors but not lipid metabolism modifiers.

(2018) Dylan Trefor Jones et al.   MOLECULAR CANCER THERAPEUTICS

Fatty acid synthase (FASN) as a therapeutic target in breast cancer

(2017) Javier A. Menendez et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

(2017) Yiqing Du et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy

(2017) Xinjian Li et al.   MOLECULAR CELL

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice

(2017) Sabine Harlander et al.   NATURE MEDICINE

Metabolic reprogramming in clear cell renal cell carcinoma

(2017) Hiromi I. Wettersten et al.   Nature Reviews Nephrology

Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis

(2017) L Jin et al.   ONCOGENE

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

(2017) Weinan Du et al.   Nature Communications

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

(2016) A. Ari Hakimi et al.   CANCER CELL

Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1-Mediated Lipogenesis

(2016) F. Geng et al.   CLINICAL CANCER RESEARCH

ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs

(2016) Christopher R. LaPensee et al.   ENDOCRINOLOGY

Long-term Use of Statins and Risk of Renal Cell Carcinoma: A Population-based Case–Control Study

(2016) Anton Pottegård et al.   EUROPEAN UROLOGY

Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015)

(2016) Yan-Ting Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma

(2016) Xinsheng Wang et al.   UROLOGIA INTERNATIONALIS

The Obesity Paradox in Cancer: a Review

(2016) Hannah Lennon et al.   Current Oncology Reports

ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch

(2016) Steven Zhao et al.   Cell Reports

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

(2016) Kosuke Saito et al.   Scientific Reports

Angiomyolipoma with Minimal Fat

(2015) Lifen Yan et al.   ACADEMIC RADIOLOGY

Infiltrating neutrophils promote renal cell carcinoma (RCC) proliferation via modulating androgen receptor (AR) → c-Myc signals

(2015) Wenbin Song et al.   CANCER LETTERS

Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis

(2015) H. I. Wettersten et al.   CANCER RESEARCH

Uncoupling Nuclear Receptor LXR and Cholesterol Metabolism in Cancer

(2015) Fabiola Bovenga et al.   Cell Metabolism

ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment

(2015) Amrita Khwairakpam et al.   CURRENT DRUG TARGETS

Fast clearance of lipid droplets through MAP1S-activated autophagy suppresses clear cell renal cell carcinomas and promotes patient survival

(2015) Guibin Xu et al.   Oncotarget

Prognostic Value of Malic Enzyme and ATP-Citrate Lyase in Non-Small Cell Lung Cancer of the Young and the Elderly

(2015) Agnes Csanadi et al.   PLoS One

Therapeutic Strategies for Metabolic Diseases: Small-Molecule Diacylglycerol Acyltransferase (DGAT) Inhibitors

(2014) Ravi Naik et al.   ChemMedChem

The pharmacology of statins

(2014) Cesare R. Sirtori   PHARMACOLOGICAL RESEARCH

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

An Epidemiologic and Genomic Investigation Into the Obesity Paradox in Renal Cell Carcinoma

(2013) A. Ari Hakimi et al.   JNCI-Journal of the National Cancer Institute

Reciprocal Regulation of HIF-1α and LincRNA-p21 Modulates the Warburg Effect

(2013) Fan Yang et al.   MOLECULAR CELL

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

Association of Weight Status With Mortality in Adults With Incident Diabetes

(2012) Mercedes R. Carnethon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Human 5-, 12- and 15-lipoxygenase-1 coexist in kidney but show opposite trends and their balance changes in cancer

(2012) AMIRA GOHARA et al.   ONCOLOGY REPORTS

Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency

(2011) Wan Seok Yang et al.   ACS Medicinal Chemistry Letters

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Acyl-coenzyme A: Cholesterol acyltransferase inhibitor Avasimibe affect survival and proliferation of glioma tumor cell lines

(2010) Sana Bemlih et al.   CANCER BIOLOGY & THERAPY

Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia

(2010) F. Chiarini et al.   CANCER RESEARCH

Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1

(2010) M. J. Seltzer et al.   CANCER RESEARCH

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The Obesity Paradox and Mortality Associated With Surrogates of Body Size and Muscle Mass in Patients Receiving Hemodialysis

(2010) Kamyar Kalantar-Zadeh et al.   MAYO CLINIC PROCEEDINGS

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY