The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implications

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

(2018) Thomas J. Mitchell et al.   CELL

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Novel gene fusion of PRCC-MITF defines a new member of MiT family translocation renal cell carcinoma: clinicopathological analysis and detection of the gene fusion by RNA sequencing and FISH

(2018) Qiu-Yuan Xia et al.   HISTOPATHOLOGY

Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma

(2018) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

(2018) Christopher J. Ricketts et al.   Cell Reports

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

Renal cell carcinoma

(2017) James J. Hsieh et al.   Nature Reviews Disease Primers

Immune Checkpoint Therapy in Renal Cell Carcinoma

(2016) Chung-Han Lee et al.   CANCER JOURNAL

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Targeting renal cell carcinoma with a HIF-2 antagonist

(2016) Wenfang Chen et al.   NATURE

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

(2016) Suraj Peri et al.   Oncotarget

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

(2016) Fengju Chen et al.   Cell Reports

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

SWI/SNF Chromatin Remodeling and Human Malignancies

(2015) Julien Masliah-Planchon et al.   Annual Review of Pathology-Mechanisms of Disease

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

(2015) Tuncay Baubec et al.   NATURE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Merlin/NF2 inactivation in tumor biology

(2015) A M Petrilli et al.   ONCOGENE

MiT family translocation renal cell carcinoma

(2015) Pedram Argani   SEMINARS IN DIAGNOSTIC PATHOLOGY

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

(2015) Rochelle L. Tiedemann et al.   Oncotarget

SDHB-Deficient Cancers: The Role of Mutations That Impair Iron Sulfur Cluster Delivery

(2015) Neetu Saxena et al.   JNCI-Journal of the National Cancer Institute

Immune signature of tumor infiltrating immune cells in renal cancer

(2015) Katharina Geissler et al.   OncoImmunology

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft

(2015) Alexandra Borodovsky et al.   Oncotarget

The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

(2014) Caleb F. Davis et al.   CANCER CELL

Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer

(2014) Carole Sourbier et al.   CANCER CELL

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Prognostic B-cell Signatures Using mRNA-Seq in Patients with Subtype-Specific Breast and Ovarian Cancer

(2014) M. D. Iglesia et al.   CLINICAL CANCER RESEARCH

5 Mechanism based targeted therapy for hereditary leiomyomatosis and renal cell cancer (HLRCC) and sporadic papillary renal cell carcinoma: interim results from a phase 2 study of bevacizumab and erlotinib

(2014) R. Srinivasan et al.   EUROPEAN JOURNAL OF CANCER

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Spectrum of diverse genomic alterations define non–clear cell renal carcinoma subtypes

(2014) Steffen Durinck et al.   NATURE GENETICS

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

(2014) Eric C. Kauffman et al.   Nature Reviews Urology

Tumor-Specific Hypermethylation of Epigenetic Biomarkers, Including SFRP1, Predicts for Poorer Survival in Patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) Project

(2014) Christopher J. Ricketts et al.   PLoS One

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

SQSTM1 Is a Pathogenic Target of 5q Copy Number Gains in Kidney Cancer

(2013) Lianjie Li et al.   CANCER CELL

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated molecular analysis of clear-cell renal cell carcinoma

(2013) Yusuke Sato et al.   NATURE GENETICS

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma

(2012) A. Ari Hakimi et al.   EUROPEAN UROLOGY

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

BAP1 loss defines a new class of renal cell carcinoma

(2012) Samuel Peña-Llopis et al.   NATURE GENETICS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Of Mice and Men: Divergence of Gene Expression Patterns in Kidney

(2012) Lydie Cheval et al.   PLoS One

The metabolic basis of kidney cancer

(2012) W. Marston Linehan et al.   SEMINARS IN CANCER BIOLOGY

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

(2011) Ignacio Varela et al.   NATURE

The Dnmt3a PWWP Domain Reads Histone 3 Lysine 36 Trimethylation and Guides DNA Methylation

(2010) Arunkumar Dhayalan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma

(2010) M R Morris et al.   ONCOGENE

Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma

(2010) M R Morris et al.   ONCOGENE

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia

(2008) Peter Schraml et al.   MODERN PATHOLOGY

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE