Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?
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Title
Unleashing Natural Killer Cells in the Tumor Microenvironment–The Next Generation of Immunotherapy?
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-02-21
DOI
10.3389/fimmu.2020.00275
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- A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma
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- Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer
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- PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
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- KIR/HLA Interactions Negatively Affect Rituximab- but Not GA101 (Obinutuzumab)-Induced Antibody-Dependent Cellular Cytotoxicity
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- WIP: more than a WASp-interacting protein
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- The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
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- Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex
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- Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade
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- Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition
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- NMR Determines Transient Structure and Dynamics in the Disordered C-Terminal Domain of WASp Interacting Protein
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- NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
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- Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicity
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- Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
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- Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen-Specific T-cell Immunity in Head and Neck Cancer Patients
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- Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment
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- Hypoxia downregulates the expression of activating receptors involved in NK-cell-mediated target cell killing without affecting ADCC
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- Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation
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- A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer
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- Neuroblastoma-Derived TGF- 1 Modulates the Chemokine Receptor Repertoire of Human Resting NK Cells
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- Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer
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- Targeting Blockage of STAT3 in Hepatocellular Carcinoma Cells Augments NK Cell Functions via Reverse Hepatocellular Carcinoma-Induced Immune Suppression
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- Novel Interaction between Proliferating Cell Nuclear Antigen and HLA I on the Surface of Tumor Cells Inhibits NK Cell Function through NKp44
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- Blockade of A2Areceptors potently suppresses the metastasis of CD73+tumors
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- PD-1 Expression on Peripheral Blood Cells Increases with Stage in Renal Cell Carcinoma Patients and Is Rapidly Reduced after Surgical Tumor Resection
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- The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+T cells into innate-like effector cells with antitumor activity
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- TLR3 agonists improve the immunostimulatory potential of cetuximab against EGFR+head and neck cancer cells
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- Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
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- A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
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- Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
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- A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
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- Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells
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- A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
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- Primary B-CLL Resistance to NK Cell Cytotoxicity can be Overcome In Vitro and In Vivo by Priming NK Cells and Monoclonal Antibody Therapy
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- A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
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- Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
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- Cetuximab therapy in head and neck cancer: Immune modulation with interleukin-12 and other natural killer cell–activating cytokines
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- IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
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- IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR
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- Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma
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- Monoclonal Antibodies for Non-Hodgkin's Lymphoma: State of the Art and Perspectives
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- Natural Killer Cells are Scarce in Colorectal Carcinoma Tissue Despite High Levels of Chemokines and Cytokines
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- IL-15:IL-15 receptor alpha superagonist complex: High-level co-expression in recombinant mammalian cells, purification and characterization
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- Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
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- Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
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- Mechanism of Action of Type II, Glycoengineered, Anti-CD20 Monoclonal Antibody GA101 in B-Chronic Lymphocytic Leukemia Whole Blood Assays in Comparison with Rituximab and Alemtuzumab
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- Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging
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- The Suppressive Tumor Microenvironment: A Challenge in Cancer Immunotherapy
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- T cell exhaustion
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- Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose
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- Innate or Adaptive Immunity? The Example of Natural Killer Cells
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- A Phase I study of recombinant human interleukin-21 (rIL-21) in combination with sunitinib in patients with metastatic renal cell carcinoma (RCC)
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- Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
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- The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody
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- Synergistic Signals for Natural Cytotoxicity Are Required to Overcome Inhibition by c-Cbl Ubiquitin Ligase
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- Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients
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- Safety and immunologic effects of IL-15 administration in nonhuman primates
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- Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
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- Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
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- Programmed death 1 signaling on chronic myeloid leukemia-specific T cells results in T-cell exhaustion and disease progression
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- Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
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- In Vivo Expansion of Activated Naive CD8+ T Cells and NK Cells Driven by Complexes of IL-2 and Anti-IL-2 Monoclonal Antibody As Novel Approach of Cancer Immunotherapy
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- Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection
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- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
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- Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity
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- Colocalization of the IL-12 receptor and Fc RIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-
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- Human natural killer cells
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- Specificity and affinity of human Fc receptors and their polymorphic variants for human IgG subclasses
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- A phase II trial of trastuzumab in combination with low-dose interleukin-2 (IL-2) in patients (PTS) with metastatic breast cancer (MBC) who have previously failed trastuzumab
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- PRL PTPs: mediators and markers of cancer progression
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- Loss and Reduction of Fus1 Protein Expression is a Frequent Phenomenon in the Pathogenesis of Lung Cancer
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- Lenalidomide Enhances Natural Killer Cell and Monocyte-Mediated Antibody-Dependent Cellular Cytotoxicity of Rituximab-Treated CD20+ Tumor Cells
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- Approved monoclonal antibodies for cancer therapy
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- Immunoglobulin G Fragment C Receptor Polymorphisms and Clinical Efficacy of Trastuzumab-Based Therapy in Patients With HER-2/neu–Positive Metastatic Breast Cancer
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- Correlation between NK function and response to trastuzumab in metastatic breast cancer patients
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- The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
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- Functions of natural killer cells
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- The tumor microenvironment and its role in promoting tumor growth
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- WIP is essential for lytic granule polarization and NK cell cytotoxicity
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