Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents

(2018) Laura Walrave et al.   GLIA

2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association

(2018) William J. Powers et al.   STROKE

Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases

(2018) Wei Li et al.   Scientific Reports

Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells

(2017) Nunzio Vicario et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic–ischemic injury in neonatal rats

(2016) Yong Li et al.   EXPERIMENTAL NEUROLOGY

β-Caryophyllene protectsin vitroneurovascular unit against oxygen-glucose deprivation and re-oxygenation-induced injury

(2016) Xiaocui Tian et al.   JOURNAL OF NEUROCHEMISTRY

Bridging the gap to therapeutic strategies based on connexin/pannexin biology

(2016) Christian C. Naus et al.   Journal of Translational Medicine

The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation

(2016) Monica Molteni et al.   MEDIATORS OF INFLAMMATION

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory

(2016) Laura Walrave et al.   Frontiers in Cellular Neuroscience

Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats

(2015) Xiaojing Li et al.   GLIA

TAK-242, an Antagonist for Toll-like Receptor 4, Protects against Acute Cerebral Ischemia/Reperfusion Injury in Mice

(2015) Fang Hua et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

(2015) Paul M. George et al.   NEURON

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

(2015) Rainer Schulz et al.   PHARMACOLOGY & THERAPEUTICS

Computational and Pharmacological Target of Neurovascular Unit for Drug Design and Delivery

(2015) Md. Mirazul Islam et al.   Biomed Research International

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets

(2014) J.Y. Kim et al.   CURRENT MEDICINAL CHEMISTRY

Leukemia inhibitor factor promotes functional recovery and oligodendrocyte survival in rat models of focal ischemia

(2014) Derrick D. Rowe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Hunting for connexin hemichannels

(2014) Juan C. Sáez et al.   FEBS LETTERS

Neuronal NAMPT is Released after Cerebral Ischemia and Protects against White Matter Injury

(2014) Zheng Jing et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Polyinosinic-Polycytidylic Acid Has Therapeutic Effects against Cerebral Ischemia/Reperfusion Injury through the Downregulation of TLR4 Signaling via TLR3

(2014) P.-F. Wang et al.   JOURNAL OF IMMUNOLOGY

Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

(2014) Hai-tao Zhu et al.   Journal of Neuroinflammation

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae

(2014) P.M. Grace et al.   NEUROSCIENCE

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

(2014) Verónica Abudara et al.   Frontiers in Cellular Neuroscience

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

(2014) Catheleyne D'hondt et al.   Frontiers in Physiology

Isolation of Primary Murine Brain Microvascular Endothelial Cells

(2014) Tobias Ruck et al.   Jove-Journal of Visualized Experiments

A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

(2013) Qiang Xue et al.   International Journal of Biological Sciences

Time to Treatment With Intravenous Tissue Plasminogen Activator and Outcome From Acute Ischemic Stroke

(2013) Jeffrey L. Saver et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ATP Is Required and Advances Cytokine-Induced Gap Junction Formation in Microglia In Vitro

(2013) Pablo J. Sáez et al.   MEDIATORS OF INFLAMMATION

TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion

(2013) Ying Wang et al.   MEDIATORS OF INFLAMMATION

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

(2012) Nan Wang et al.   BASIC RESEARCH IN CARDIOLOGY

Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia

(2012) Helen V. Danesh-Meyer et al.   BRAIN

Pathophysiology of the Neurovascular Unit: Disease Cause or Consequence?

(2012) Danica B Stanimirovic et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation

(2012) Jiaxiang Shao et al.   JOURNAL OF NEUROIMMUNOLOGY

The vascular neural network—a new paradigm in stroke pathophysiology

(2012) John H. Zhang et al.   Nature Reviews Neurology

AGEs–RAGE mediated up-regulation of connexin43 in activated human microglial CHME-5 cells

(2012) Shamim B. Shaikh et al.   NEUROCHEMISTRY INTERNATIONAL

Carvacrol, a Food-Additive, Provides Neuroprotection on Focal Cerebral Ischemia/Reperfusion Injury in Mice

(2012) Hailong Yu et al.   PLoS One

Connexin 43 controls the multipolar phase of neuronal migration to the cerebral cortex

(2012) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-Ischemic Inflammation in the Brain

(2012) Takashi Shichita et al.   Frontiers in Immunology

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Connexin Channels Provide a Target to Manipulate Brain Endothelial Calcium Dynamics and Blood—Brain Barrier Permeability

(2011) Marijke De Bock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Investigational Therapies for Ischemic Stroke: Neuroprotection and Neurorecovery

(2011) Preeti Sahota et al.   Neurotherapeutics

Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease

(2011) Hideyuki Takeuchi et al.   PLoS One

Connexin 43 Reverses Malignant Phenotypes of Glioma Stem Cells by Modulating E-Cadherin

(2011) Shi-Cang Yu et al.   STEM CELLS

Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia

(2011) Xiaoxing Xiong et al.   STROKE

Connexin Modulators and Their Potential Targets under the Magnifying Glass

(2010) S. B. Bodendiek et al.   CURRENT MEDICINAL CHEMISTRY

Role of connexin43 in central nervous system injury

(2010) Shenton S.L. Chew et al.   EXPERIMENTAL NEUROLOGY

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Degeneration and repair in central nervous system disease

(2010) Eng H Lo   NATURE MEDICINE

Astroglial networks: a step further in neuroglial and gliovascular interactions

(2010) Christian Giaume et al.   NATURE REVIEWS NEUROSCIENCE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury

(2010) Ghayda Hawat et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Connexin43 Mimetic Peptides Reduce Swelling, Astrogliosis, and Neuronal Cell Death after Spinal Cord Injury

(2008) Simon J. O'Carroll et al.   CELL COMMUNICATION AND ADHESION

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model

(2008) E Decrock et al.   CELL DEATH AND DIFFERENTIATION

A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

(2008) Shinsuke Nakagawa et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons

(2008) S. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial toll-like receptor signaling in central nervous system infection and autoimmunity

(2007) Pamela A. Carpentier et al.   BRAIN BEHAVIOR AND IMMUNITY