Review
Oncology
Jea Giezl N. Solidum, Raniv D. Rojo, Jennifer Y. Wo, Edward Christopher Dee
Summary: Early-stage esophageal cancer is usually treated with surgery, and radiotherapy is added for locally advanced disease. However, current photon-based radiotherapy regimens result in high complications, and the anatomical location of the esophagus poses challenges for radiotherapy. This review focuses on proton beam therapy (PBT) for esophageal cancer, including treatment planning, clinical comparisons with photon-based techniques, ongoing trials, challenges, toxicities, and issues of equity and health services.
Article
Oncology
Liang Du, Da Wang, Peter W. Nagle, Andries A. H. Groen, Hao Zhang, Christina T. Muijs, John Th M. Plukker, Robert P. Coppes
Summary: Esophageal cancer is a highly aggressive disease with poor prognosis. The hypoxia-responding mTOR pathway plays a crucial role in the regulation of esophageal cancer stem-like cells (CSCs). Targeting the mTOR pathway could be a potential therapeutic strategy for eliminating putative esophageal CSCs.
Article
Materials Science, Biomaterials
Shuying Li, Wenjie Sun, Yuan Luo, Yanping Gao, Xueping Jiang, Cheng Yuan, Linzhi Han, Kuo Cao, Yan Gong, Conghua Xie
Summary: A novel hollow PtCo nanosphere-based radiosensitizer is proposed with advantages including higher radiation absorption, dual catalase-like enzymatic activity converting H2O2 to O2 efficiently, and a large specific surface area amplifying catalytic reaction of H2O2 to induce reactive oxygen species and cancer cell apoptosis upon combination with radiation. Both in vivo and in vitro studies demonstrate the significant inhibition of tumor growth and relief of tumor hypoxia with good biocompatibility and biosafety, presenting a simple but multifunctional radiosensitizer for enhancing radiotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu, Weiyu Shen
Summary: This study found that circBCAR3 is highly expressed in esophageal cancer and it can promote the tumorigenesis of esophageal cancer by interacting with miR-27a-3p to upregulate TNPO1. The splicing factor QKI was identified as a positive regulator of circBCAR3 and hypoxia upregulates E2F7 to transcriptionally activate QKI.
Article
Chemistry, Multidisciplinary
Wei Zhou, Zhulong Liu, Nana Wang, Xue Chen, Xiaozheng Sun, Yufeng Cheng
Summary: This study demonstrates a simple method for synthesizing UiO-66-NH2(Hf) metal-organic framework nanoparticles as radiosensitizers for radiotherapy. The nanoparticles have a stable structure and enhanced X-ray absorption, making them a promising option for esophageal cancer radiotherapy.
Review
Oncology
Plabon Kumar Das, Farhadul Islam, Robert A. Smith, Alfred K. Lam
Summary: Cancer stem cells play a key role in esophageal cancer initiation, progression, and therapy resistance. Targeting signaling pathways, miRNA expression profiles, and hypoxia factors could provide effective therapeutic options against esophageal CSCs. Further research is needed to validate these strategies and potential therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vera L. Silva, Amalia Ruiz, Ahlam Ali, Sara Pereira, Jani Seitsonen, Janne Ruokolainen, Fiona Furlong, Jonathan Coulter, Wafa' T. Al-Jamal
Summary: Novel cupric-tirapazamine [Cu(TPZ)2]-liposomes were developed as an effective hypoxia-targeted therapeutic, which potentiated radiotherapy in a three dimensional (3D) prostate cancer (PCa) model. The highest loading efficiency was obtained at neutral pH, and enhanced drug loading was achieved upon decreasing the lipid:complex molar ratio.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Dechao Jiao, Kunpeng Wu, Kaihao Xu, Yiming Liu, Deyao Zhao, Xinwei Han, Ruitai Fan
Summary: In this study, a folic acid-decorated palladium decahedral nanoenzyme was prepared to target and modify the hypoxic tumor microenvironment while enhancing radiation energy deposition within tumor tissues. Compared to palladium nanodots, these decahedral constructs showed prolonged in vivo circulation, allowing for sustained radiosensitization. This novel approach highlights a potential direction for future clinical research in improving I-125 seed interstitial implantation therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Oncology
Caitlin T. Demarest, Andrew C. Chang
Summary: Esophagectomy is the main treatment for resectable esophageal cancer, with chemotherapy and chemoradiation as essential adjunct therapies. The optimal perioperative therapy remains controversial. Three landmark trials have established chemotherapy and chemoradiotherapy as standard care, with ongoing research aiming to clarify the roles of different regimens in esophageal cancer treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ahmed Ali Chughtai, Julia Pannhausen, Pia Dinger, Julia Wirtz, Ruth Knuechel, Nadine T. Gaisa, Michael J. Eble, Michael Rose
Summary: This study investigates the impact of pharmacological inhibition of DDR targets on bladder cancer cells. The results demonstrate that DNA-PK and ATR inhibitors can sensitize bladder cancer cells to ionizing radiation by delaying DNA repair. Moreover, the synergistic effect of combined DDR inhibition varies among different cell lines.
Review
Oncology
Cordell Gilreath, Marjan Boerma, Zhiqiang Qin, M. Keith Hudson, Shanzhi Wang
Summary: Breast cancer is a significant health issue in the U.S., with a high incidence and mortality rate. Radiation therapy is commonly used in treatment, but tumor resistance to radiation poses a major challenge. Tumor cells residing in a hypoxic microenvironment promote resistance to radiation therapy, as well as cancer proliferation and metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Xijuan Yao, Shuting Lu, Cheng Feng, Ruiyang Suo, Hang Li, Yi Zhang, Qi Chen, Jian Lu, Bo Wu, Jinhe Guo
Summary: This study proposes a new strategy to overcome the resistance of esophageal cancer to 125I brachytherapy. By co-encapsulating catalase and a HIF-1 inhibitor into liposomes, researchers were able to generate oxygen and reduce the expression of hypoxia-related proteins, improving the radiosensitivity of brachytherapy and leading to the eradication of esophageal cancer.
Article
Multidisciplinary Sciences
Hao Li, Meng Wang, Biao Huang, Su-Wen Zhu, Jun-Jie Zhou, De-Run Chen, Ran Cui, Mingxi Zhang, Zhi-Jun Sun
Summary: A nanoprobe based on NIR-IIb emitting quantum dots was designed to alleviate hypoxia in the tumor microenvironment, enhancing precision and efficacy of radiotherapy, and promoting anti-tumor immune responses.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Xin Wang, Brian Hobbs, Saumil J. Gandhi, Christina T. Muijs, Johannes A. Langendijk, Steven H. Lin
Summary: Esophageal cancer remains a leading cause of cancer death globally. While early-stage disease can be surgically treated, locally advanced disease is typically managed with concurrent chemoradiation, with proton therapy showing potential benefits in reducing complications and improving survival outcomes.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Kuan-Heng Lin, Chen-Xiong Hsu, Shan-Ying Wang, Greta S. P. Mok, Chiu-Han Chang, Hui-Ju Tien, Pei-Wei Shueng, Tung-Hsin Wu
Summary: This study developed a volume-based algorithm (VBA) to predict lung V-5 and optimize lung dose in treatment planning. The predicted lung V-5 was positively correlated with actual lung V-5, while a decrease in arc angle led to a decrease in lung dose and an increase in heart dose.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Tiuri E. Kroese, Peter S. N. van Rossum, Magnus Nilsson, Florian Lordick, Elizabeth C. Smyth, Riccardo Rosati, Philippe Nafteux, Domenico D'Ugo, M. Asif Chaudry, Wojciech Polkowkski, Franco Roviello, Ines Gockel, Piotr Kolodziejczyk, Karin Haustermans, Matthias Guckenberger, Marianne Nordsmark, Maria A. Hawkins, Andres Cervantes, Tania Fleitas, Eric van Cutsem, Markus Moehler, Anna D. Wagner, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: Currently, there is a lack of uniform definition and treatment for oligometastatic esophagogastric cancer. The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement to improve outcomes for these patients.
Article
Oncology
Katja R. Worth, Ioanna Papandreou, Ester M. Hammond
Summary: Louis Harold Gray's pivotal research in the 1950s demonstrated the vital role of oxygen in radiotherapy. This research inspired further studies into the mechanistic role of molecular oxygen and its relationship with tumor hypoxia and patient outcomes. Despite the abundance of pre-clinical data supporting hypoxia-targeted treatments, the clinical application of these therapies remains limited.
BRITISH JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Antoine L. D. Wallabregue, Hannah Bolland, Stephen Faulkner, Ester M. Hammond, Stuart J. Conway
Summary: Hypoxia, which occurs in various biological contexts, has a negative impact on the survival of biological systems such as plants, bacterial biofilms, and tumors. Chemical probes that can study biological hypoxia help to improve the understanding and treatment of diseases related to low oxygen levels. This study presents a range of indolequinone-based bioreductive fluorescent probes that can image different levels of hypoxia in cellular cultures, providing a convenient alternative to antibody-based imaging approaches.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Medicine, General & Internal
Christopher M. Jones, Heather O'Connor, Maria O'Donovan, Daniel Hayward, Adrienn Blasko, Ruth Harman, Shalini Malhotra, Irene Debiram-Beecham, Bincy Alias, Adam Bailey, Andrew Bateman, Tom D. L. Crosby, Stephen Falk, Simon Gollins, Maria A. Hawkins, Sudarshan Kadri, Stephanie Levy, Ganesh Radhakrishna, Rajarshi Roy, Raj Sripadam, Rebecca C. Fitzgerald, Somnath Mukherjee
Summary: This study evaluated the safety and acceptability of using the Cytosponge (TM) to assess treatment response in patients with oesophageal squamous cell carcinoma (OSCC) or adenocarcinoma (OAC) undergoing chemoradiotherapy (CRT). The findings suggest that the Cytosponge (TM) is safe, tolerable, and acceptable for evaluating treatment response in this population, supporting further evaluation of its use in this setting.
Article
Oncology
M. Robinson, R. Muirhead, D. R. Mcgowan, K. -Y. Chu, C. Jacobs, M. A. Hawkins
Summary: The definition of active pelvic bone marrow as FDG uptake greater than the mean of the whole structure can represent underlying cell physiology. This study supports the feasibility of atlas-based approaches published in the literature to contour active bone marrow based on the current definition.
Article
Oncology
Tiuri E. Kroese, Hanneke W. M. van Laarhoven, Sebastian F. Schoppman, Pieter R. A. J. Deseyne, Eric van Cutsem., Karin Haustermans., Philippe. Nafteux, Melissa Thomas, Radka Obermannova, Hanna R. Mortensen, Marianne Nordsmark, Per Pfeiffer, Anneli Elme, Antoine Adenis, Guillaume Piessen, Christiane J. Bruns, Florian Lordick, Ines Gockel, Markus Moehler, Cihan Gani, Theodore Liakakos, John Reynolds, Alessio G. Morganti, Riccardo Rosati, Carlo Castoro, Francesco Cellini, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Mark I. van Berge Henegouwen, Maarten C. C. M. Hulshof, Jolanda van Dieren, Marieke Vollebergh, Johanna W. van Sandick, Paul Jeene, Christel T. Muijs, Marije Slingerland, Francine E. M. Voncken, Henk Hartgrink, Geert-Jan Creemers, Maurice J. C. van der Sangen, Grard Nieuwenhuijzen, Maaike Berbee, Marcel Verheij, Bas Wijnhoven, Laurens V. Beerepoot, Nadia H. Mohammad, Stella Mook, Jelle P. Ruurda, Piotr Kolodziejczyk, Wojciech P. Polkowski, Lucjan Wyrwicz, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Andres Cervantes, Magnus Nilsson, Stefan Monig, Anna D. Wagner, Matthias Guckenberger, Ewen A. Griffiths, Elizabeth Smyth, George B. Hanna, Sheraz Markar, M. Asif Chaudry, Maria A. Hawkins, Edward Cheong, Richard van Hillegersberg, Peter S. N. van Rossum
Summary: This study aimed to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Through a series of discussions and expert evaluations, a consensus was reached, which can be used for future research in clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Michael D. Chuong, Christopher J. Anker, Michael H. Buckstein, Maria A. Hawkins, Jordan Kharofa, Ann C. Raldow, Nina N. Sanford, Andrzej Wojcieszysnki, Jeffrey R. Olsen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Marie H. C. Boulet, Hannah R. Bolland, Ester M. Hammond, Adam C. Sedgwick
Summary: Platinum (IV) anticancer agents show potential to overcome limitations of commonly used Pt (II) chemotherapeutics and an improved understanding of their intracellular reduction is needed. Two fluorescence responsive oxaliplatin (IV) complexes, OxaliRes and OxaliNap, were synthesized and showed increased fluorescence emission intensity upon reduction by sodium ascorbate (NaAsc). Treatment with NaAsc increased fluorescence intensity in a dose-dependent manner in colorectal cancer cells. Hypoxia-induced reduction of OxPt (IV) complexes with <0.1% O-2 resulted in the greatest fluorescence signal and showed significant differences in toxicity compared to normoxia (21% O-2).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Oncology
Katarzyna B. Leszczynska, Monika Dzwigonska, Hala Estephan, Jutta Moehlenbrink, Elizabeth Bowler, Amato J. Giaccia, Jakub Mieczkowski, Bozena Kaminska, Ester M. Hammond
Summary: Local hypoxia in solid tumors is associated with aggressive disease and therapy resistance. Widespread changes in gene expression occur in response to hypoxia, with decreased chromatin accessibility and specific pathways affected. The RNA helicase DDX5 is repressed in hypoxia and its rescue further accumulates replication stress and R-loop levels. These findings suggest that the repression of multiple R-loop processing factors, including DDX5, is a critical part of the biological response to hypoxia.
MOLECULAR ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Simon M. Rushbrook, Timothy James Kendall, Yoh Zen, Raneem Albazaz, Prakash Manoharan, Stephen P. Pereira, Richard Sturgess, Brian R. Davidson, Hassan Z. Malik, Derek Manas, Nigel Heaton, K. Raj Prasad, John Bridgewater, Juan W. Valle, Rebecca Goody, Maria Hawkins, Wendy Prentice, Helen Morement, Martine Walmsley, Shahid A. Khan
Summary: These guidelines commissioned by the British Society of Gastroenterology liver section provide guidance for the diagnosis and management of cholangiocarcinoma (CCA). The writing committee includes a multidisciplinary team of experts and patient/public representatives. Quality of evidence is evaluated using the AGREE II format. The recommendations are meant to guide rather than serve as strict references.
Editorial Material
Oncology
Krishan R. Jethwa, William S. Harmsen, Maria A. Hawkins, Hyun Kim, Nina N. Sanford, Andrzej P. Wojcieszynski, Jeffrey R. Olsen
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Tiffany S. Ma, Katja R. Worth, Conor Maher, Natalie Ng, Chiara Beghe, Natalia Gromak, Anna M. Rose, Ester M. Hammond
Summary: Hypoxia, a common feature of solid tumors, can lead to the accumulation of R-loops, which affects gene transcription and ribosomal RNA synthesis, playing a critical role in tumorigenesis.
NUCLEIC ACIDS RESEARCH
(2023)
Letter
Oncology
Sean M. O'Cathail, Richard Adams, Maria A. Hawkins, David Sebag-Montefiore, Corrie A. M. Marijnen, Emmanouil Fokas
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Cagla Tosun, Antoine L. D. Wallabregue, Maxim Mallerman, Sarah E. Phillips, Claire M. Edwards, Stuart J. Conway, Ester M. Hammond
Summary: Hypoxia-activated prodrugs (HAPs) are a promising strategy for targeting hypoxic regions in tumors while sparing normal tissue. However, visualizing the delivery and activation of HAPs in hypoxic regions has been a challenge. In this study, a modified version of a nitroimidazole bioreductive group was developed to enable imaging of the release of a fluorescent dye and the activation of the prodrug using the EF5 antibody. This modified bioreductive group was used to synthesize a new prodrug, EF5-Pano, which showed imaging capability and cytotoxic effects in hypoxic multiple myeloma cells.
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
