Article
Chemistry, Medicinal
Na Li, Manyi Xu, Lulu Zhang, Zhichao Lei, Cheng Chen, Tianyuan Zhang, Li Chen, Jianbo Sun
Summary: By introducing substituted imidazoles, significant improvements in antiproliferation, covalent-binding ability, and Hsp90-Cdc37 inhibition were achieved compared to CEL. Compound 9, the most potent derivative, showed higher activity in inducing apoptosis and inhibiting tumor growth in vivo. This study provides support for the development of CEL and other Michael acceptors as antitumor agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Tao Li, Farideh Mehraein-Ghomi, M. Elizabeth Forbes, Sanjeev Namjoshi, E. Ashley Ballard, Qianqian Song, Ping-Chieh Chou, Xuya Wang, Brittany C. Parker Kerrigan, Frederick F. Lang, Glenn Lesser, Waldemar Debinski, Xuejun Yang, Wei Zhang
Summary: The FGFR3-TACC3 fusion gene is highly expressed in various cancers and affects the treatment of glioblastoma. Its activity is dependent on heat shock protein 90 and cell division cycle 37, and inhibition of these proteins can suppress its oncogenic function. Additionally, HSP90 inhibitors can enhance the sensitivity of glioma cells with this fusion gene to chemotherapy.
Article
Biochemistry & Molecular Biology
Na Li, Cheng Chen, Huiting Zhu, Zhixian Shi, Jianbo Sun, Li Chen
Summary: Compound 6, designed to enhance the disruption of Hsp90-Cdc37, showed enhanced anti-proliferative activity on cancer cell lines, inhibited the expression of key clients, and induced tumor cell apoptosis. The compound's increased activity may be attributed to its enhanced covalent binding with thiols and ability to arrest cells in the G0/G1 phase. Further exploration of compound 6 for cancer treatment is warranted.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Farid A. Siddiqui, Vladimir Vukic, Tiina A. Salminen, Daniel Abankwa
Summary: Elaiophylin is a macrodiolide that disrupts the interaction between Hsp90 and Cdc37, selectively targeting K-Ras and inhibiting cancer stem cell properties. This mechanism is similar to conglobatin A and leads to decreased expression of Hsp90 client HIF1 alpha, resulting in potent effects on cancer cell formation.
Review
Chemistry, Medicinal
Lei Wang, Qiuyue Zhang, Qidong You
Summary: Heat shock protein 90 (HSP90) is crucial in cancer cells, but its inhibitors have limited efficacy and side effects. Researchers are investigating the disruption of the HSP90-CDC37-kinase complex as an alternative solution to avoid limitations.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Yan Cheng, Fumou Sun, Krista Thornton, Xuefang Jing, Jing Dong, Grant Yun, Michael Pisano, Fenghuang Zhan, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Parameswaran Hari, Siegfried Janz
Summary: FOXM1 plays a crucial role in myeloma metabolism by regulating glycolysis and oxidative phosphorylation pathways. Inhibiting FOXM1 can effectively suppress myeloma growth, offering potential new approaches for therapy and prevention.
Article
Multidisciplinary Sciences
Dimitra Keramisanou, M. V. Vasantha Kumar, Nicole Boose, Rinat R. Abzalimov, Ioannis Gelis
Summary: This study investigates the recruitment and loading mechanism of protein kinases to the Hsp90-Cdc37 complex, which is the first step in Hsp90-mediated chaperoning. The results show that the conformational dynamics of all partners are critical for the loading mechanism, and that Cdc37 plays a role in sensing clients by stabilizing the preexisting partially unfolded client state. These findings reveal the regulatory mechanism of molecular chaperones in maintaining protein homeostasis.
Article
Biochemistry & Molecular Biology
Sara Garcia-Alonso, Pablo Mesa, Laura de la Puente Ovejero, Gonzalo Aizpurua, Carmen G. Lechuga, Eduardo Zarzuela, Clara M. Santiveri, Manuel Sanclemente, Javier Munoz, Monica Musteanu, Ramon Campos-Olivas, Jorge Martinez-Torrecuadrada, Mariano Barbacid, Guillermo Montoya
Summary: This study describes the structure of the RAF1 protein in complex with HSP90 and CDC37. The research reveals that CDC37 can differentiate between different members of the RAF family. Additionally, the study shows that folded RAF1 assembles with 14-3-3 dimers, and disrupting the interaction between CDC37 and RAF1 may have potential therapeutic implications.
Article
Biochemistry & Molecular Biology
Jan Paul Mueller, Karl-Heinz Klempnauer
Summary: HIPK2 is a constitutively active serine/threonine protein kinase involved in important biological processes, regulated by autophosphorylation during synthesis and ubiquitin-dependent degradation. A novel regulatory mechanism of HIPK2 involving preferential co-translational degradation of kinase-defective HIPK2 has been identified, with a potential role of chaperones such as CDC37-HSP90 complex in this process.
Article
Oncology
Farid Ahmad Siddiqui, Hanna Parkkola, Vladimir Vukic, Christina Oetken-Lindholm, Alok Jaiswal, Alexandros Kiriazis, Karolina Pavic, Tero Aittokallio, Tiina A. Salminen, Daniel Abankwa
Summary: The correct folding of proteins is crucial for cellular activity. Hsp90, together with Cdc37, plays a potentially more important role in several cancer cells by stabilizing mutant kinases and assisting other cancer-related proteins. The inhibition of Hsp90/Cdc37 interface by drug-like small molecules shows promise in potential applications for various cancers, including pancreatic cancer. Further research is needed to understand the mechanisms and therapeutic potential of these inhibitors.
Article
Chemistry, Multidisciplinary
Chuan-jing Cheng, Kai-xin Liu, Man Zhang, Fu-kui Shen, Li-li Ye, Wen-bo Wu, Xiao-tao Hou, Er-wei Hao, Yuan-yuan Hou, Gang Bai
Summary: This study identified a novel natural inhibitor of HSP90, okicamelliaside (OCS), which selectively inhibits the formation of the HSP90-CDC37 protein complex and disrupts protein-protein interactions of HSP90-CDC37 to exert anti-tumor effects.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Andrology
Kun Li, Peibei Sun, Yayan Wang, Tian Gao, Dongwang Zheng, Ajuan Liu, Ya Ni
Summary: This study revealed the interaction between Hsp90 and Cdc37 in human spermatozoa and showed that PKA and PKC signaling pathways regulate total protein threonine phosphorylation and Src phosphorylation during sperm capacitation. The results help to understand the mechanism underlying Hsp90 regulation of sperm function.
Article
Oncology
Arleigh McCurdy, Hira Mian, Richard LeBlanc, Victor H. Jimenez-Zepeda, Jiandong Su, Esther Masih-Khan, Alissa Visram, Martha Louzada, Kevin Song, Darrell White, Michael Sebag, Julie Stakiw, Anthony Reiman, Muhammad Aslam, Debra Bergstrom, Rami Kotb, Rayan Kaedbey, Engin Gul, Donna Reece, Christopher P. Venner
Summary: This study analyzed the attrition rates of newly diagnosed multiple myeloma patients who did not receive subsequent therapy after initial treatment, and found that the attrition rates increase with each line of therapy and are higher in non-autologous stem cell transplant patients. Death was identified as the main contributor to attrition in all patient cohorts. Rating: 8 out of 10.
BLOOD CANCER JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Oxana Lungu, Denise Toscani, Jessica Burroughs-Garcia, Nicola Giuliani
Summary: The study of osteoblast metabolism has attracted increasing attention recently due to its high energy demand during bone remodeling. In addition to glucose, recent data show that amino acid and fatty acid metabolism plays an important role in providing fuel for osteoblast functioning. Glutamine has been identified as a crucial amino acid for osteoblast differentiation and activity. This review focuses on the metabolic pathways involved in the fate and functions of osteoblasts, particularly in multiple myeloma (MM) bone disease where the presence of malignant plasma cells disrupts osteoblast formation and activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dennis M. Bjorklund, R. Marc L. Morgan, Jasmeen Oberoi, Katie L. I. M. Day, Panagiota A. Galliou, Chrisostomos Prodromou
Summary: The study identified the interaction between CDC37 and BRAF and determined the crucial structural elements of CDC37 involved in BRAF recognition. The dimerization of BRAF can inhibit the recognition by CDC37, and the consequences of BRAF mutations on signaling were discussed.
Article
Computer Science, Cybernetics
Renata Wachowiak-Smolikova, Haibin Zhu
Summary: This article presents an adaptive computational methodology called Role-based Collaboration (RBC) that uses roles to facilitate and analyze system behavior in collaborative entities. The use of visualization provides insights into complex system behaviors in dynamic environments. The results show that time-varying systems can be optimized and assessed using visual analytics (VA) dashboards.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Obstetrics & Gynecology
Miaomiao Ye, Wenbin Huang, Fengyun Chen, Weinan Chen, Xueqiong Zhu
Summary: This study investigated the volume change of uterine leiomyomas during pregnancy and explored factors affecting their growth trends. The results showed that the growth rate of uterine leiomyomas was higher from the first to second trimester compared to the second to third trimester. Smaller leiomyomas were more likely to increase in size during pregnancy, and retroplacental leiomyomas were more likely to increase in volume compared to those located away from the placenta.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Computer Science, Cybernetics
Haibin Zhu
Summary: In this issue, four articles are introduced, while the other three articles for the special section Next-Generation Networks for Industry 4.0 will be outlined in the special session editorial by guest editors Haisheng Yu, Jiehan Zhou, Zhixiong Chen, Yongzhi Wang, and Madhusanka Liyanage. They are highly appreciated for their effective work in collecting high-quality submissions.
IEEE SYSTEMS MAN AND CYBERNETICS MAGAZINE
(2023)
Article
Computer Science, Cybernetics
Qian Jiang, Haibin Zhu, Yan Qiao, Dongning Liu, Baoying Huang
Summary: This article introduces a method for group role assignment that considers cooperation and conflict factors to maximize team performance. It addresses two bottlenecks in practical applications and proposes a team evaluation method to help decision-makers establish sustainable teams. Large-scale simulation experiments demonstrate the feasibility and robustness of the proposed solution.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Computer Science, Cybernetics
Peiyun Zhang, Xiaoqi Hua, Haibin Zhu
Summary: Blockchain as a ledger technology offers decentralization without the need for central servers. Cross-chain technology can connect different blockchains and enable interoperability and information sharing. This work designs a cross-chain digital asset system that includes two parallel chains and a relay chain. The proposed system ensures secure trading and payment through the transmission of cross-chain messages. Testing and analysis show that the system provides more secure trading and payment compared to its peers.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Microbiology
Hai-Yan Zhu, Xu-Yang Wei, Xin-Zhan Liu, Feng-Yan Bai
Summary: A new yeast species belonging to the basidiomycetous yeast genus Cystofilobasidium was isolated from a marine sediment sample in Shandong province, China. Phylogenetic analysis based on gene sequences showed that this strain represents a novel species, named Cystofilobasidium josepaulonis sp. nov. This species differs from known species in the genus in terms of DNA sequence mismatches and teliospore germination behavior.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Oncology
Han Wang, Xin Chen, Yanshan Jin, Tingxian Liu, Yizuo Song, Xuejie Zhu, Xueqiong Zhu
Summary: This study aims to clarify the role and underlying molecular pathways of DYNLT3 in breast cancer tumorigenesis. Differential expression of DYNLT3 was detected in breast cancer tissues and cells, showing that DYNLT3 may act as a tumor-promoter in age-associated breast cancer. Knockdown of DYNLT3 suppressed cell growth, migration, and invasion, and induced cell apoptosis, highlighting its potential as a therapeutic target for breast cancer.
Article
Oncology
Xin Chen, Mengying Jiang, Shengjie Zhou, Hong Chen, Gendi Song, Yichen Wu, Xueqiong Zhu
Summary: Preferentially expressed antigen in melanoma (PRAME), a member of the CTA gene family, was found to be highly expressed in cervical cancer tissues and cells compared with control groups. PRAME promoted cell proliferation, migration, and invasion while reducing cell apoptosis and G0/G1 arrest by activating the Wnt/beta-catenin pathway. These findings may have implications for future cervical cancer treatments.
Article
Computer Science, Cybernetics
Lu Liang, Jingdong Fu, Haibin Zhu, Dongning Liu
Summary: This article studies the team allocation problem in mass crowdsourcing. To ensure the rapid completion of tasks and maintain the enthusiasm and income of workers, tasks are assigned to multiple teams with limitations on worker participation. The article proposes a formalized problem based on extending GMRA and presents a solution. Simulation experiments demonstrate the efficiency and feasibility of the proposed approach.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Computer Science, Cybernetics
Haibin Zhu
Summary: This article presents a model for simulating resource/benefit distribution and checks for Pareto improvements using a revised GRA model. The study shows that Pareto improvements are not possible when resources are insufficient, and can only be achieved when there are sufficient resources and manpower.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Engineering, Biomedical
Shuya Pan, Zhengwei Sun, Bo Zhao, Liqing Miao, Qingfeng Zhou, Tianfeng Chen, Xueqiong Zhu
Summary: This review focuses on the application of Mn-based nanomaterials in radiotherapy. These nanomaterials can enhance the efficacy of radiotherapy by alleviating tumor hypoxia, increasing reactive oxygen species production, increasing GSH conversion, and promoting antitumor immunity. Furthermore, they can also serve as contrast agents for precision therapy.
Article
Oncology
Bo Sheng, Bo Zhao, Yue Dong, Jiamin Zhang, Suni Wu, Huihui Ji, Xueqiong Zhu
Summary: This study investigated the expression and function of CPNE1 in ovarian cancer. The results showed that CPNE1 overexpression was associated with poor prognosis in ovarian cancer and promoted tumor cell proliferation, invasion, and migration. Furthermore, CPNE1 was found to mediate M2 macrophage polarization and upregulate CD163, CD206, and interleukin-10, suggesting a potential therapeutic target for ovarian cancer.
Article
Computer Science, Cybernetics
Qian Jiang, Dongning Liu, Haibin Zhu, Yan Qiao, Baoying Huang
Summary: This article explores the team allocation problem from a dynamic perspective, proposing the revised group role assignment problem to achieve balance in resources and abilities within teams. Through large-scale simulation experiments, it reveals the paradox of equilibrium.
IEEE TRANSACTIONS ON COMPUTATIONAL SOCIAL SYSTEMS
(2023)
Article
Oncology
Miaomiao Ye, Tingxian Liu, Liqing Miao, Shuangwei Zou, Huihui Ji, Jian'an Zhang, Xueqiong Zhu
Summary: Zinc finger protein 275 (ZNF275) has been found to be highly expressed in cervical cancer tissues and downregulation of ZNF275 can inhibit tumor growth and weaken the AKT/Bcl-2 signaling pathway. Additionally, the AKT inhibitor triciribine synergizes with cisplatin to enhance the therapeutic effect on cervical cancer cells expressing high ZNF275. The combination treatment of triciribine and cisplatin is more effective in inducing tumor regression than single agents in cervical cancer PDX models expressing high ZNF275.
Review
Cell & Tissue Engineering
Yizuo Song, Hejing Liu, Shuya Pan, Xinli Xiang, Miaomiao Ye, Xueqiong Zhu
Summary: Mesenchymal stromal cells (MSCs) have shown great promise in various fields such as regenerative medicine and cancer therapy. However, their role as important components within the tumor microenvironment poses potential tumorigenic risks, hindering their clinical translation.
STEM CELL RESEARCH & THERAPY
(2023)