Metabolic Reprogramming and Host Tolerance: A Novel Concept to Understand Sepsis-Associated AKI

Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy

(2021) Chuyi Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Innovations and emerging therapies to combat renal cell damage: NAD+ as a drug target

(2021) Carlos L Manrique-Caballero et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of PGC-1α in the Mitochondrial NAD+ Pool in Metabolic Diseases

(2021) Jin-Ho Koh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness

(2020) Kui Jin et al.   FASEB JOURNAL

Revisiting the Warburg effect: historical dogma versus current understanding

(2020) Peter Vaupel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury

(2019) Jian-xing Liu et al.   LIFE SCIENCES

Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

(2019) Christine Podrini et al.   CELLULAR SIGNALLING

Increased Fatty Acid Oxidation in Differentiated Proximal Tubular Cells Surviving a Reversible Episode of Acute Kidney Injury

(2018) Aurélien Bataille et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

The clinical utility of splenic fluorodeoxyglucose uptake for diagnosis and prognosis in patients with macrophage activation syndrome

(2017) Sung Soo Ahn et al.   MEDICINE

Metabolic reprogramming and tolerance during sepsis-induced AKI

(2017) Hernando Gómez et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock

(2016) John A. Kellum et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis results in an altered renal metabolic and osmolyte profile

(2016) Paul Waltz et al.   JOURNAL OF SURGICAL RESEARCH

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS

(2016) Steven M. Opal et al.   SHOCK

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

(2015) Daniel A. Escobar et al.   JOURNAL OF SURGICAL RESEARCH

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

(2015) S. H. Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Mitochondrial Function and Disturbances in the Septic Kidney

(2015) Samir M. Parikh et al.   SEMINARS IN NEPHROLOGY

Acute kidney injury in septic patients admitted to emergency clinical room: risk factors and outcome

(2014) Pâmela Medeiros et al.   Clinical and Experimental Nephrology

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Soluble CD25 is increased in patients with sepsis-induced acute kidney injury

(2014) Eunjung Cho et al.   NEPHROLOGY

Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy

(2014) Raghavan Murugan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

Risk Factors for Mortality in Patients with Septic Acute Kidney Injury in Intensive Care Units in Beijing, China: A Multicenter Prospective Observational Study

(2014) Xin Wang et al.   Biomed Research International

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Proximal Tubule Function and Response to Acidosis

(2013) N. P. Curthoys et al.   Clinical Journal of the American Society of Nephrology

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

(2013) Stacey Ruiz et al.   KIDNEY INTERNATIONAL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

'Biologic memory' in response to acute kidney injury: cytoresistance, toll-like receptor hyper-responsiveness * and the onset of progressive renal disease

(2013) R. A. Zager   NEPHROLOGY DIALYSIS TRANSPLANTATION

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

A Unified Theory of Sepsis-Induced Acute Kidney Injury

(2013) Hernando Gomez et al.   SHOCK

Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice

(2012) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Insufficient Autophagy Contributes to Mitochondrial Dysfunction, Organ Failure, and Adverse Outcome in an Animal Model of Critical Illness*

(2012) Jan Gunst et al.   CRITICAL CARE MEDICINE

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

(2011) Paul Waltz et al.   Autophagy

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

(2011) Evie H. Carchman et al.   HEPATOLOGY

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Endotoxin Uptake by S1 Proximal Tubular Segment Causes Oxidative Stress in the Downstream S2 Segment

(2011) R. Kalakeche et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

(2011) Hsiu-Wen Hsiao et al.   SHOCK

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view

(2008) Gilad Twig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast

(2008) E. Easlon et al.   GENES & DEVELOPMENT

Endotoxin Mediates Recruitment of RNA Polymerase II to Target Genes in Acute Renal Failure

(2008) M. Naito et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY