A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression

Quantitative Proteomics of the Cancer Cell Line Encyclopedia

(2020) David P. Nusinow et al.   CELL

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression

(2020) Juan Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton

(2020) Wenqing Zhou et al.   JOURNAL OF CELL SCIENCE

Mitochondrial ubiquinol oxidation is necessary for tumour growth

(2020) Inmaculada Martínez-Reyes et al.   NATURE

The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells

(2020) Jie Li et al.   Science Signaling

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC REGULATION OF A MITOCHONDRIAL TRAFFICKING NETWORK MEDIATES TUMOR CELL INVASION AND METASTASIS

(2019) Ekta Agarwal et al.   MOLECULAR AND CELLULAR BIOLOGY

Loss of parkin reduces lung tumor development by blocking p21 degradation

(2019) Kyung-Ran Park et al.   PLoS One

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits

(2019) Jagadish C. Ghosh et al.   ONCOGENE

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

(2018) Sarah Pickles et al.   CURRENT BIOLOGY

Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics

(2018) Alban Ordureau et al.   MOLECULAR CELL

The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?

(2018) David Moulder et al.   Cancers

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

(2018) Changfeng Li et al.   DEVELOPMENTAL CELL

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer

(2018) Subhamoy Dasgupta et al.   NATURE

Mitochondrial dynamics and metastasis

(2018) Dario C. Altieri   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers

(2018) Yi Ding et al.   Nature Communications

Correcting for natural isotope abundance and tracer impurity in MS-, MS/MS- and high-resolution-multiple-tracer-data from stable isotope labeling experiments with IsoCorrectoR

(2018) Paul Heinrich et al.   Scientific Reports

Miro1-mediated mitochondrial positioning shapes intracellular energy gradients required for cell migration

(2017) Max-Hinderk Schuler et al.   MOLECULAR BIOLOGY OF THE CELL

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Parkin-Independent Mitophagy Controls Chemotherapeutic Response in Cancer Cells

(2017) Elodie Villa et al.   Cell Reports

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak

(2017) Valentina Debattisti et al.   Cell Reports

PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease

(2017) Francois Mouton-Liger et al.   Frontiers in Molecular Neuroscience

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondria and Cancer

(2016) Sejal Vyas et al.   CELL

Regulators of mitochondrial dynamics in cancer

(2016) Daniela Senft et al.   CURRENT OPINION IN CELL BIOLOGY

AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion

(2016) Brian Cunniff et al.   MOLECULAR BIOLOGY OF THE CELL

Parkin and mitophagy in cancer

(2016) J P Bernardini et al.   ONCOGENE

A neuronal network of mitochondrial dynamics regulates metastasis

(2016) M. Cecilia Caino et al.   Nature Communications

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

(2016) Jae Ho Seo et al.   PLOS BIOLOGY

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts

(2015) Fee Bengsch et al.   CELL CYCLE

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

Mitochondrial Localization and the Persistent Migration of Epithelial Cancer cells

(2013) Salil P. Desai et al.   BIOPHYSICAL JOURNAL

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

(2013) M. Cecilia Caino et al.   JOURNAL OF CLINICAL INVESTIGATION

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Redox Regulation of p53, Redox Effectors Regulated by p53: A Subtle Balance

(2011) Agnès Maillet et al.   ANTIOXIDANTS & REDOX SIGNALING

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

(2010) G. Poulogiannis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

(2009) Selvaraju Veeriah et al.   NATURE GENETICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY