Article
Endocrinology & Metabolism
Juliane Weiner, Lisa Roth, Mathias Kranz, Peter Brust, Anita Boelen, Nora Kloeting, John T. Heiker, Matthias Blueher, Anke Toenjes, Paul T. Pfluger, Michael Stumvoll, Jens Mittag, Kerstin Krause
Summary: This study identified a previously unknown endocrine loop where leptin acts in concert with the HPT axis to stabilize body temperature in hypothyroid mice. Leptin regulates body temperature not only by directly affecting heat production, but also by stimulating the HPT axis to maintain TH serum levels.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Lidan Zhao, Honglin Jiang
Summary: The inhibitory effect of growth hormone (GH) on adipose tissue growth is achieved partially by stimulating lipolysis. GH injection in GH-deficient lit/lit mice resulted in a reduction in adipose tissue size. However, GH does not directly affect basal or isoproterenol-induced lipolysis or enhance beta-adrenergic receptors-mediated lipolysis in adipose tissue or adipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Michalina Banaszak, Ilona Gorna, Juliusz Przyslawski
Summary: Numerous studies have shown that zinc and ZAG play crucial roles in lipid metabolism, with zinc supplementation improving hepatic lipid metabolism and reducing cholesterol levels. ZAG has been demonstrated to reduce obesity and enhance insulin sensitivity, showing potential benefits in cardiovascular health.
Article
Biology
Yanis Zekri, Romain Guyot, Ines Garteizgogeascoa Suner, Laurence Canaple, Amandine Gautier Stein, Justine Vily Petit, Denise Aubert, Sabine Richard, Frederic Flamant, Karine Gauthier
Summary: This study used transcriptome and cistrome analyses to identify direct target genes of thyroid hormone (T3) in brown adipocytes and developed a new mouse model to study the role of T3 in brown adipose tissue (BAT). The results showed that T3 plays a crucial role in regulating lipid and glucose metabolism and BAT proliferation, providing new insights into the pathways by which T3 activates energy expenditure through adaptive thermogenesis in BAT.
Article
Nutrition & Dietetics
Flavia G. De Carvalho, Vitor R. Munoz, Camila F. C. Brandao, Fernando M. Simabuco, Isadora C. B. Pavan, Susana C. B. R. Nakandakari, Jose Rodrigo Pauli, Leandro P. De Moura, Eduardo R. Ropelle, Julio Sergio Marchini, Adelino S. R. da Silva, Ellen C. de Freitas
Summary: Taurine supplementation showed positive effects on insulin signaling and mitochondrial metabolism in mice and adipocytes. However, the 8-week taurine administration did not change the expression of related proteins in the adipose tissue of obese women.
Article
Biochemistry & Molecular Biology
Yi-Hsin Tseng, Cheng-Chih Chang, Kwang-Huei Lin
Summary: Recent studies have shown that T3 can promote rapid turnover of lysosomes and expression of numerous lysosomal genes, enhancing lysosomal activity in digesting any additional autophagosomal burden. Lysosomes play an important role in autophagy, but limited research has been conducted on this topic.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Minh-Hanh Thi Nguyen, Dat Da Ly, Nhung Thi Nguyen, Xu-Feng Qi, Hyon-Seung Yi, Minho Shong, Seung-Kuy Cha, Sangkyu Park, Kyu-Sang Park
Summary: Short-term exposure to T-3 induces UCP1 upregulation and mitochondrial activation in brown adipocytes through PLC-mediated elevation of [Ca2+].
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Muhammad Ali Mohsin, Huiru Yu, Rongze He, Peng Wang, Linli Gan, Yulan Du, Yunfei Huang, Muhammad Bakhsh Abro, Sarmad Sohaib, Mariusz Pierzchala, Przemyslaw Sobiech, Klaudia Mietkiewska, Chandra S. Pareek, Bao Xiang He
Summary: This study investigated the changes in blood parameters and liver function indicators, as well as the expression of related genes in adipose tissue, in ketotic cows and healthy control cows. The results showed that during the postpartum period, ketotic cows had higher plasma levels of GH, which may lead to the mobilization of adipose tissue and the occurrence of hyperketonemia.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Endocrinology & Metabolism
Valentina Capelli, Carlos Dieguez, Jens Mittag, Miguel Lopez
Summary: Huge advances have been achieved in the field of thyroid hormone (TH) action on energy balance in the past decade, particularly with the recent discovery of TH's 'central' metabolic action in rodent models. By analyzing bench models, the two paradigms have been dissected and unified to explore their possible translational implications.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Leila Soltani, Sorayya Kheirouri, Elgar Enamzadeh
Summary: The serum levels of S100A1 and ZAG are significantly elevated in heart failure patients compared to healthy controls. There is a strong positive correlation between the serum levels of S100A1 and ZAG in HF patients, while these levels are negatively correlated with BMI and arm circumference.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Genetics & Heredity
Wen-Na Zhang, Hao Zhu, Zhen-Wu Ma, Jing Yu, Yun Yang, Xuan-Bei Lu, Yi-Fan Lv, Xiao-Dong Wang
Summary: This study investigated the functional changes in subcutaneous adipose tissue (SAT) with aging, focusing on gene expression and chromatin accessibility. The results revealed that aging is associated with altered gene expression, particularly in genes related to mitochondrial function and oxidative stress. The findings also suggest that impaired mitochondrial function in SAT of elderly individuals may be attributed to insensitivity to thyroid hormone signaling.
BMC MEDICAL GENOMICS
(2023)
Article
Multidisciplinary Sciences
KyeongJin Kim, Jin Ku Kang, Young Hoon Jung, Sang Bae Lee, Raffaela Rametta, Paola Dongiovanni, Luca Valenti, Utpal B. Pajvani
Summary: The removal of adipocyte-specific phosphatase PHLPP2 can improve glucose homeostasis in obese mice fed a high-fat diet, possibly due to PHLPP2 dephosphorylation of HSL. This suggests that PHLPP2 may play a significant role in obesity-related metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Pharmacology & Pharmacy
Qianyu Tang, Min Zeng, Linxi Chen, Nian Fu
Summary: This review discusses the role of the thyroid hormone/thyroid hormone receptor axis in liver diseases, including its beneficial effects on metabolic-associated fatty liver disease, hepatitis, liver fibrosis, and liver injury, as well as its detrimental effects on the progression of acute liver failure and alcoholic liver disease. Moreover, the TH/TR axis exhibits paradoxical roles in hepatocellular carcinoma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jose Ignacio Martinez-Montoro, Luis Ocana-Wilhelmi, Rocio Soler-Humanes, Hanieh Motahari-Rad, Andres Gonzalez-Jimenez, Jose Rivas-Becerra, Alba Rodriguez-Munoz, Francisco J. Moreno-Ruiz, Monica Tome, Jorge Rodriguez-Capitan, Eduardo Garcia-Fuentes, Francisco J. Tinahones, Lourdes Garrido-Sanchez, Mora Murri
Summary: ZAG, an adipokine involved in adipocyte metabolism, has been found to be associated with metabolic parameters in obese patients. Lower levels of SAT and VAT ZAG expression are related to adverse metabolic profiles. However, the baseline expression of ZAG did not seem to affect the outcomes of bariatric surgery.
Article
Biochemistry & Molecular Biology
Hugo Ramos, Patricia Bogdanov, Rafael Simo, Anna Deas-Just, Cristina Hernandez
Summary: Synaptic dysfunction and neuronal damage are closely associated with diabetic retinopathy (DR). This study explored the effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on retinal expression patterns in an experimental model of DR. Transcriptome analysis revealed that sitagliptin eye drops significantly affected retinal expression patterns, with neurotransmission being the most enriched biological process. The study suggests that topical administration of sitagliptin improves abnormalities in presynaptic and postsynaptic signal transmission during DR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Jose Raul Herance, Andreea Ciudin, Ruben Lamas-Domingo, Carolina Aparicio-Gomez, Cristina Hernandez, Rafael Simo, Martina Palomino-Schatzlein
Summary: The prevalence of diabetes type 1 (T1D) is increasing worldwide. This study aimed to find new biomarkers of T1D in red blood cells (RBCs), which have not been explored before. The metabolomic and lipidomic profiles of RBCs from T1D patients and healthy controls were analyzed using NMR spectroscopy. Significant changes were observed in amino acids, organic acids, creatine, phosphocreatine, lipid length, and choline derivatives. These changes indicate alterations in glycolysis, BCAA metabolism, and phospholipid metabolism. The study concluded that the metabolic and lipidomic profile of RBCs can be used as biomarker candidates for the earlier diagnosis and monitoring of T1D patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Rafael Simo, Cristina Hernandez
Article
Endocrinology & Metabolism
Rafael Simo, Cristina Hernandez
Summary: The classical modifiable factors associated with the onset and progression of diabetic retinopathy include suboptimal control of blood glucose levels and hypertension, as well as dyslipidaemia. However, there are other less recognized modifiable factors, such as obesity and abnormal distribution of adipose tissue, as well as lifestyle factors like diet, vitamin intake, exercise, smoking, and sunlight exposure, that can play a relevant role. This article discusses the prevention of diabetic retinopathy by modulating these risk factors and explores the potential impact of glucose-lowering drugs on the condition. It also highlights the emerging concept of neurodegeneration as an early event in the development of diabetic retinopathy and discusses the potential of neuroprotection as a therapeutic strategy to prevent advanced stages of the disease.
Review
Biochemistry & Molecular Biology
Hugo Ramos, Cristina Hernandez, Rafael Simo, Olga Simo-Servat
Summary: The etiology of diabetic retinopathy (DR) involves multiple factors and affects the retinal neurovascular unit (NVU). DR has a chronic low-grade inflammatory component, and understanding its mechanisms allows the development of new therapeutic strategies. This review article summarizes the latest research on the role of inflammation in DR and discusses the efficacy of current anti-inflammatory treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Queralt Martin-Saladich, Rafael Simo, Santiago Aguade-Bruix, Olga Simo-Servat, Carolina Aparicio-Gomez, Cristina Hernandez, Clara Ramirez-Serra, Maria Nazarena Pizzi, Albert Roque, Miguel A. Gonzalez A. Ballester, Jose Raul Herance
Summary: In this study, the myocardial dynamics in insulin-sensitive (mIS) and insulin-resistant (mIR) type 2 diabetes (T2D) patients were investigated for the first time. The results suggest that there are different risk indicators for mIS and highly calcified subjects, and personalized approaches to assess T2D may lead to more efficient treatments and risk-prevention strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nuria Alcubierre, Minerva Granado-Casas, Patricia Bogdanov, Cristina Hernandez, Hugo Ramos, Esmeralda Castelblanco, Jordi Real, Esther Rubinat-Arnaldo, Alicia Traveset, Marta Hernandez, Carmen Jurjo, Jesus Vioque, Eva Maria Navarrete-Munoz, Rafael Simo, Didac Mauricio
Summary: The study evaluated the potential benefits of caffeine intake in preventing the development of diabetic retinopathy (DR) in patients with type 2 diabetes (T2D). The cross-sectional study showed a protective effect of moderate and high caffeine intake on DR. However, the experimental model did not demonstrate any improvement in reactive gliosis or retinal vascular permeability with caffeine administration.
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Olga Simo-Servat, Judit Amigo, Monica Sanchez, Carla Morer, Josep Franch-Nadal, Regina Mayor, Tim Snel, Rafael Simo, Cristina Hernandez
Summary: This study evaluated the efficacy of self-management of insulin titration based on information received by the Short Message Service (SMS). The results showed that SMS-guided titration improved glycemic control and significantly improved psychological aspects related to insulin treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Betina Biagetti, Irene Valenzuela, Ariadna Campos-Martorell, Berta Campos, Sara Hernandez, Marina Giralt, Noelia Diaz-Troyano, Emilio Iniesta-Serrano, Diego Yeste, Rafael Simo
Summary: This report describes a case of short stature in an adult patient with homozygous variants in the ADAMTS17 and GHS-R genes. The patient exhibited severe short stature, small hands and feet, and eye disturbances. Genetic testing revealed compound homozygosity for ADAMTS17, responsible for Weill-Marchesani-like syndrome, as well as homozygous variants in the GHS-R gene. Dynamic stimulation tests showed a normal GH response to insulin tolerance test but a flattened response to macimorelin stimulus. The findings provide insights into the clinical spectrum, associated co-morbidities, implications in dynamic tests, genetic counseling, and treatment options for both the index case and her relatives.
Article
Endocrinology & Metabolism
Cristina Hernandez, Olga Simo-Servat, Massimo Porta, Jakob P. Grauslund, Simon Harding, Ulrik Frydkjaer-Olsen, Jose Garcia-Arumi, Luisa Ribeiro, Peter Scanlon, Jose Cunha-Vaz, Rafael Simo
Summary: This study aimed to assess the usefulness of serum biomarkers GFAP and NfL in identifying and monitoring retinal neurodysfunction in type 2 diabetes patients. The levels of GFAP and NfL in the serum were directly correlated with age and with each other. Additionally, higher baseline levels of GFAP were found in patients who showed progression of neurodysfunction after 2 years of follow-up.
ACTA DIABETOLOGICA
(2023)
