TNFSF14: LIGHTing the Way for Effective Cancer Immunotherapy

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

(2020) Bo He et al.   Cell Reports

A safe and potent anti-CD19 CAR T cell therapy

(2019) Zhitao Ying et al.   NATURE MEDICINE

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

(2019) Katrin Mestermann et al.   Science Translational Medicine

Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules

(2018) Bo He et al.   JOURNAL OF PATHOLOGY

TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β

(2018) Ricardo da Silva Antunes et al.   Frontiers in Immunology

Targeting VEGF/VEGFR to Modulate Antitumor Immunity

(2018) Ju Yang et al.   Frontiers in Immunology

Immunomodulation of Tumor Vessels: It Takes Two to Tango

(2018) Anna Johansson-Percival et al.   TRENDS IN IMMUNOLOGY

LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens

(2018) Giacomina Brunetti et al.   Frontiers in Immunology

The Tumor Necrosis Factor Superfamily Members TNFSF14 (LIGHT), Lymphotoxin β and Lymphotoxin β Receptor Interact to Regulate Intestinal Inflammation

(2018) Daniel A. Giles et al.   Frontiers in Immunology

Monitoring of tumor vascular normalization: the key points from basic research to clinical application

(2018) Wei Li et al.   Cancer Management and Research

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression

(2017) Hongling Zhang et al.   ONCOLOGY REPORTS

Combined antiangiogenic and anti–PD-L1 therapy stimulates tumor immunity through HEV formation

(2017) Elizabeth Allen et al.   Science Translational Medicine

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression

(2017) María de la Luz García-Hernández et al.   Frontiers in Immunology

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

(2017) Emily Jayne Colbeck et al.   Frontiers in Immunology

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

The TNF Receptor Superfamily in Co-stimulating and Co-inhibitory Responses

(2016) Lindsay K. Ward-Kavanagh et al.   IMMUNITY

Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers

(2016) Marie-Caroline Dieu-Nosjean et al.   IMMUNOLOGICAL REVIEWS

A tissue microarray study of toll-like receptor 4, decoy receptor 3, and external signal regulated kinase 1/2 expressions in astrocytoma

(2016) Dueng-Yuan Hueng et al.   Indian Journal of Pathology and Microbiology

LIGHT/IFN-γ triggers β cells apoptosisviaNF-κB/Bcl2-dependent mitochondrial pathway

(2016) Quan-You Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The control of tissue fibrosis by the inflammatory molecule LIGHT (TNF Superfamily member 14)

(2016) Rana Herro et al.   PHARMACOLOGICAL RESEARCH

Decoy Receptor 3 (DcR3) as a Biomarker of Tumor Deterioration in Female Reproductive Cancers: A Meta-Analysis

(2016) Mengtong Jiang et al.   MEDICAL SCIENCE MONITOR

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Tumor microenvironment: Sanctuary of the devil

(2015) Lanlan Hui et al.   CANCER LETTERS

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

(2015) Anna Johansson-Percival et al.   Cell Reports

CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function

(2015) Eunyoung Chun et al.   Cell Reports

Adenovirus Improves the Efficacy of Adoptive T-cell Therapy by Recruiting Immune Cells to and Promoting Their Activity at the Tumor

(2015) S. Tahtinen et al.   Cancer Immunology Research

Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT

(2014) Tim D. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes

(2014) Lisa Yan et al.   PROSTATE

Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma

(2014) Suning Huang et al.   TheScientificWorldJOURNAL

Tertiary lymphoid structures in cancer and beyond

(2014) Marie-Caroline Dieu-Nosjean et al.   TRENDS IN IMMUNOLOGY

Death decoy receptor overexpression and increased malignancy risk in colorectal cancer

(2014) Liang Zong   WORLD JOURNAL OF GASTROENTEROLOGY

Decoy receptor 3 (DcR3) overexpression predicts the prognosis and pN2 in pancreatic head carcinoma

(2014) Jian Zhou et al.   World Journal of Surgical Oncology

Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues

(2014) Theresa T. Lu et al.   Frontiers in Immunology

Characteristics of tertiary lymphoid structures in primary cancers

(2014) Jérémy Goc et al.   OncoImmunology

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

License for destruction: Tumor-specific cytokine targeting

(2013) Anna Johansson et al.   TRENDS IN MOLECULAR MEDICINE

Phase I and pharmacodynamic study of high-dose NGR–hTNF in patients with refractory solid tumours

(2012) P A Zucali et al.   BRITISH JOURNAL OF CANCER

Phase II study of NGR-hTNF in combination with doxorubicin in relapsed ovarian cancer patients

(2012) D Lorusso et al.   BRITISH JOURNAL OF CANCER

LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response

(2012) W. Zou et al.   CANCER RESEARCH

The Next Challenge in Cancer Immunotherapy: Controlling T-Cell Traffic to the Tumor

(2012) J.-P. Abastado   CANCER RESEARCH

Tumor-targeted TNF  stabilizes tumor vessels and enhances active immunotherapy

(2012) A. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Phase I Study of NGR-hTNF, a Selective Vascular Targeting Agent, in Combination with Cisplatin in Refractory Solid Tumors

(2011) V. Gregorc et al.   CLINICAL CANCER RESEARCH

TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)

(2011) Carl F Ware et al.   CURRENT OPINION IN IMMUNOLOGY

The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation

(2011) Marcos W. Steinberg et al.   IMMUNOLOGICAL REVIEWS

Targeted Drug Delivery and Penetration Into Solid Tumors

(2011) Angelo Corti et al.   MEDICINAL RESEARCH REVIEWS

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling

(2011) Taylor A Doherty et al.   NATURE MEDICINE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma

(2011) L. Agemy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone marrow-derived mesenchymal stem cells and the tumor microenvironment

(2010) Scott A. Bergfeld et al.   CANCER AND METASTASIS REVIEWS

Expression of LIGHT/TNFSF14 Combined with Vaccination against Human Papillomavirus Type 16 E7 Induces Significant Tumor Regression

(2010) S. Kanodia et al.   CANCER RESEARCH

Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect

(2010) Guili Hu et al.   Cellular & Molecular Immunology

Chemokines in cancer related inflammation

(2010) Paola Allavena et al.   EXPERIMENTAL CELL RESEARCH

Promoting Immune Responses by LIGHT in the Face of Abundant Regulatory T Cell Inhibition

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Immune infiltration in human tumors: a prognostic factor that should not be ignored

(2009) F Pagès et al.   ONCOGENE

Targeting tumors with LIGHT to generate metastasis-clearing immunity

(2008) Ping Yu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Comparative Analysis of the Expression Patterns of Various TNFSF/TNFRSF in Atherosclerotic Plaques

(2008) Won-Jung Kim et al.   IMMUNOLOGICAL INVESTIGATIONS