Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

(2018) Yao-Qing Chen et al.   CELL

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

(2018) Wataru Ise et al.   IMMUNITY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM + and Transient IgG + Memory B Cells

(2018) Kathryn A. Pape et al.   IMMUNITY

Intranasal Live Influenza Vaccine Priming Elicits Localized B Cell Responses in Mediastinal Lymph Nodes

(2018) Sinthujan Jegaskanda et al.   JOURNAL OF VIROLOGY

Similar Epitope Specificities of IgG and IgA Antibodies Elicited by Ad26 Vector Prime, Env Protein Boost Immunizations in Rhesus Monkeys

(2018) Zi Han Kang et al.   JOURNAL OF VIROLOGY

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating T FH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

(2018) Marios Koutsakos et al.   Science Translational Medicine

Efficacy, immunogenicity, and safety evaluation of an MF59-adjuvanted quadrivalent influenza virus vaccine compared with non-adjuvanted influenza vaccine in children: a multicentre, randomised controlled, observer-blinded, phase 3 trial

(2018) Timo Vesikari et al.   Lancet Respiratory Medicine

IgA Responses to Microbiota

(2018) Jeffrey J. Bunker et al.   IMMUNITY

IL-9 receptor signaling in memory B cells regulates humoral recall responses

(2018) Shogo Takatsuka et al.   NATURE IMMUNOLOGY

Innovative approaches to track lymph node germinal center responses to evaluate development of broadly neutralizing antibodies in human HIV vaccine trials

(2018) M. Patricia D'Souza et al.   VACCINE

Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion

(2018) Doan C. Nguyen et al.   Nature Communications

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

The Transcriptional Regulation of Germinal Center Formation

(2018) Shuang Song et al.   Frontiers in Immunology

Adult Bone Marrow Three-Dimensional Phenotypic Landscape of B-Cell Differentiation

(2018) Claire Carrion et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

(2018) Karlynn E. Neu et al.   JOURNAL OF CLINICAL INVESTIGATION

Comparative immunogenicity of enhanced seasonal influenza vaccines in older adults: a systematic review and meta-analysis

(2018) Tiffany W Y Ng et al.   JOURNAL OF INFECTIOUS DISEASES

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals

(2017) Giuliana Magri et al.   IMMUNITY

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

CD73 expression identifies a subset of IgM+ antigen-experienced cells with memory attributes that is T cell and CD40 signalling dependent

(2017) Lucas D'Souza et al.   IMMUNOLOGY

The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells

(2017) Brian J. Laidlaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Early Emergence of CD19-Negative Human Antibody-Secreting Cells at the Plasmablast to Plasma Cell Transition

(2017) Gururaj Arumugakani et al.   JOURNAL OF IMMUNOLOGY

Influenza A haemagglutinin specific IgG responses in children and adults after seasonal trivalent live attenuated influenza vaccination

(2017) Shahinul Islam et al.   VACCINE

Effectiveness of MF59-adjuvanted seasonal influenza vaccine in the elderly: A systematic review and meta-analysis

(2017) Alexander Domnich et al.   VACCINE

Strong Clonal Relatedness between Serum and Gut IgA despite Different Plasma Cell Origins

(2017) Rasmus Iversen et al.   Cell Reports

The Antibody-Secreting Cell Response to Infection: Kinetics and Clinical Applications

(2017) Michael J. Carter et al.   Frontiers in Immunology

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory

(2016) Alexander D. Gitlin et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Human Memory B Cells in Healthy Gingiva, Gingivitis, and Periodontitis

(2016) Rangsini Mahanonda et al.   JOURNAL OF IMMUNOLOGY

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

Regulated selection of germinal-center cells into the memory B cell compartment

(2016) Ryo Shinnakasu et al.   NATURE IMMUNOLOGY

Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

(2016) Mats Bemark et al.   Nature Communications

Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer

(2016) Colin Havenar-Daughton et al.   Cell Reports

Bone Marrow Mesenchymal Stem Cells Enhance the Differentiation of Human Switched Memory B Lymphocytes into Plasma Cells in Serum-Free Medium

(2016) Guillaume Bonnaure et al.   Journal of Immunology Research

Investigating the effect of AS03 adjuvant on the plasma cell repertoire following pH1N1 influenza vaccination

(2016) J. D. Galson et al.   Scientific Reports

A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

(2015) H. E. Mei et al.   BLOOD

Distinct germinal center selection at local sites shapes memory B cell response to viral escape

(2015) Yu Adachi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Reassessment of IgM Memory Subsets in Humans

(2015) Davide Bagnara et al.   JOURNAL OF IMMUNOLOGY

Evaluation of the Safety and Immunogenicity of a Candidate Pandemic Live Attenuated Influenza Vaccine (pLAIV) Against Influenza A(H7N9)

(2015) Mahdee Sobhanie et al.   JOURNAL OF INFECTIOUS DISEASES

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Class-switched memory B cells remodel BCRs within secondary germinal centers

(2015) Louise J McHeyzer-Williams et al.   NATURE IMMUNOLOGY

Human Ebola virus infection results in substantial immune activation

(2015) Anita K. McElroy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memory

(2014) Yinsheng Xu et al.   CELL RESEARCH

Generation of memory B cells inside and outside germinal centers

(2014) Toshitada Takemori et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

(2014) Sandra Zehentmeier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systematic Comparison of Gene Expression between Murine Memory and Naive B Cells Demonstrates That Memory B Cells Have Unique Signaling Capabilities

(2014) M. M. Tomayko et al.   JOURNAL OF IMMUNOLOGY

Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells

(2014) K. L. Good et al.   JOURNAL OF IMMUNOLOGY

CCR6-Dependent Positioning of Memory B Cells Is Essential for Their Ability To Mount a Recall Response to Antigen

(2014) Raul Elgueta et al.   JOURNAL OF IMMUNOLOGY

Tissue Distribution and Dependence of Responsiveness of Human Antigen-Specific Memory B Cells

(2014) C. Giesecke et al.   JOURNAL OF IMMUNOLOGY

A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

(2014) Kawsar R. Talaat et al.   JOURNAL OF INFECTIOUS DISEASES

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

(2014) Dan Liu et al.   NATURE

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine

(2014) Tara M. Babu et al.   VACCINE

Polysaccharide-specific B cell responses to vaccination in humans

(2014) Ruth Mitchell et al.   Human Vaccines & Immunotherapeutics

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

B-lymphocyte lineage cells and the respiratory system

(2013) Atsushi Kato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Fluorescent In Vivo Detection Reveals that IgE+ B Cells Are Restrained by an Intrinsic Cell Fate Predisposition

(2012) Zhiyong Yang et al.   IMMUNITY

The establishment of the plasma cell survival niche in the bone marrow

(2012) Van T. Chu et al.   IMMUNOLOGICAL REVIEWS

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

(2012) Tomohiro Kaji et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A germinal center–independent pathway generates unswitched memory B cells early in the primary response

(2012) Justin J. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid and Massive Virus-Specific Plasmablast Responses during Acute Dengue Virus Infection in Humans

(2012) J. Wrammert et al.   JOURNAL OF VIROLOGY

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin Responses at the Mucosal Interface

(2011) Andrea Cerutti et al.   Annual Review of Immunology

Regulation of memory B-cell survival by the BH3-only protein Puma

(2011) C. Clybouw et al.   BLOOD

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Memory B cells, but not long-lived plasma cells, possess antigen specificities for viral escape mutants

(2011) Whitney E. Purtha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

(2011) M. Bonsignori et al.   JOURNAL OF VIROLOGY

Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response

(2011) K. A. Pape et al.   SCIENCE

The genetic network controlling plasma cell differentiation

(2011) Stephen L. Nutt et al.   SEMINARS IN IMMUNOLOGY

Staying alive: regulation of plasma cell survival

(2011) Stuart G. Tangye   TRENDS IN IMMUNOLOGY

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

(2011) Ben-Jiang Ma et al.   PLoS Pathogens

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

(2010) H. E. Mei et al.   BLOOD

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells

(2010) J. SMITH-RAVIN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Elucidation of seventeen human peripheral blood B-cell subsets and quantification of the tetanus response using a density-based method for the automated identification of cell populations in multidimensional flow cytometry data

(2010) Yu Qian et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Memory B and memory plasma cells

(2010) Taketoshi Yoshida et al.   IMMUNOLOGICAL REVIEWS

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Hierarchy of Maturity of Murine Memory B Cell Subsets

(2010) M. M. Tomayko et al.   JOURNAL OF IMMUNOLOGY

Premature replacement of   with   immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

(2010) S. Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Marginal Zone B Cells

(2009) Jean-Claude Weill et al.   Annual Review of Immunology

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

(2009) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Memory B cells: Effectors of long-lived immune responses

(2009) Stuart G. Tangye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation

(2009) Tri Giang Phan et al.   NATURE IMMUNOLOGY

Mechanism of action of licensed vaccine adjuvants

(2009) Elaine Tritto et al.   VACCINE

Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies

(2009) Xiaodong Xiao et al.   Viruses-Basel

Blood-borne human plasma cells in steady state are derived from mucosal immune responses

(2008) H. E. Mei et al.   BLOOD

The human spleen is a major reservoir for long-lived vaccinia virus-specific memory B cells

(2008) M. Mamani-Matsuda et al.   BLOOD

APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells

(2008) E. Belnoue et al.   BLOOD

The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes

(2008) S. Tabera et al.   HAEMATOLOGICA

Human memory B cells: Memory B cells of a special kind

(2008) Ralf Küppers   IMMUNOLOGY AND CELL BIOLOGY

Somatic diversification in the absence of antigen-driven responses is the hallmark of the IgM+IgD+CD27+B cell repertoire in infants

(2008) Sandra Weller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Discriminating gene expression profiles of memory B cell subpopulations

(2008) Götz R.A. Ehrhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

(2008) Jens Wrammert et al.   NATURE

Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia

(2008) H. M. Joo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA