Critical Role of Synovial Tissue–Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation

Does tissue imprinting restrict macrophage plasticity?

(2021) Martin Guilliams et al.   NATURE IMMUNOLOGY

Critical role of synovial tissue–resident macrophage niche in joint homeostasis and suppression of chronic inflammation

(2021) Qi-Quan Huang et al.   Science Advances

Mapping the musculoskeletal system one cell at a time

(2021) Mathew J. Baldwin et al.   Nature Reviews Rheumatology

Location, location, location: how the tissue microenvironment affects inflammation in RA

(2021) Christopher D. Buckley et al.   Nature Reviews Rheumatology

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

(2021) Jasna Friščić et al.   IMMUNITY

Cross-tissue organization of the fibroblast lineage

(2021) Matthew B. Buechler et al.   NATURE

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update

(2020) Josef S Smolen et al.   ANNALS OF THE RHEUMATIC DISEASES

NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis

(2020) Hui Liu et al.   Cell Death & Disease

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

(2020) Jinghua Wang et al.   Frontiers in Immunology

Macrophage: A Potential Target on Cartilage Regeneration

(2020) Tiago Lazzaretti Fernandes et al.   Frontiers in Immunology

Understanding Refractory Rheumatoid Arthritis: Implications for a Therapeutic Approach

(2020) Andrew R. Melville et al.   DRUGS

The safety of baricitinib in patients with rheumatoid arthritis

(2020) Suguru Honda et al.   Expert Opinion On Drug Safety

Synovial Macrophages in Rheumatoid Arthritis: The Past, Present, and Future

(2020) Jiajie Tu et al.   MEDIATORS OF INFLAMMATION

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes

(2020) Gyrid Nygaard et al.   Nature Reviews Rheumatology

Inhibiting roles of long non‐coding RNA OIP5‐AS1 in rheumatoid arthritis progression through the microRNA‐448/PON1/TLR3/NF‐κB axis

(2020) Pingying Qing et al.   EXPERIMENTAL PHYSIOLOGY

Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis

(2020) Stefano Alivernini et al.   NATURE MEDICINE

RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares

(2020) Dana E. Orange et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR‐17‐5p reduces inflammation and bone erosions in collagen induced arthritis mice and directly targets the JAK‐STAT pathway in rheumatoid arthritis fibroblast‐like synoviocytes

(2020) Aurélie Najm et al.   Arthritis & Rheumatology

Innate immunity drives pathogenesis of rheumatoid arthritis

(2020) Maria I. Edilova et al.   Biomedical Journal

Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: First report of FAPME, a phase I clinical trial

(2020) S. Hiltbrunner et al.   ANNALS OF ONCOLOGY

Macrophages and the maintenance of homeostasis

(2020) David M. Mosser et al.   Cellular & Molecular Immunology

CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway

(2020) Shengtao Sun et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Long non-coding RNA PVT1 can regulate the proliferation and inflammatory responses of rheumatoid arthritis fibroblast-like synoviocytes by targeting microRNA-145-5p

(2020) Jiajun Tang et al.   Human Cell

Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis

(2020) Maya H. Buch et al.   Nature Reviews Rheumatology

Polarization of Rheumatoid Macrophages by TNF Targeting Through an IL-10/STAT3 Mechanism

(2019) Yannick Degboé et al.   Frontiers in Immunology

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis

(2019) Christopher Loh et al.   ANNALS OF THE RHEUMATIC DISEASES

Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis

(2019) Nicole Hannemann et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct fibroblast subsets drive inflammation and damage in arthritis

(2019) Adam P. Croft et al.   NATURE

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

Hesperidin inhibits synovial cell inflammation and macrophage polarization through suppression of the PI3K/AKT pathway in complete Freund's adjuvant-induced arthritis in mice

(2019) Weizhong Qi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Functionally distinct fibroblast subsets in RA

(2019) Jessica McHugh   Nature Reviews Rheumatology

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Long Non-coding RNA HIX003209 Promotes Inflammation by Sponging miR-6089 via TLR4/NF-κB Signaling Pathway in Rheumatoid Arthritis

(2019) Shushan Yan et al.   Frontiers in Immunology

Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)

(2019) Gloria Lliso-Ribera et al.   ANNALS OF THE RHEUMATIC DISEASES

Silencing of Long Non-coding RNA HOTTIP Reduces Inflammation in Rheumatoid Arthritis by Demethylation of SFRP1

(2019) Xumin Hu et al.   Molecular Therapy-Nucleic Acids

Relapse in rheumatoid arthritis patients undergoing dose reduction and withdrawal of biologics: are predictable factors more relevant than predictive parameters? An observational prospective real-life study

(2019) Olivier Vittecoq et al.   BMJ Open

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling

(2018) Caixia Li et al.   CELL BIOLOGY INTERNATIONAL

Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis

(2018) Christopher D. Buckley et al.   Nature Reviews Rheumatology

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

(2018) Marietta Armaka et al.   Nature Communications

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation

(2018) William Stephenson et al.   Nature Communications

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

(2018) Emmanuel Karouzakis et al.   Scientific Reports

Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models

(2018) Claire E. J. Waterborg et al.   Frontiers in Immunology

Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation

(2018) Yaoyao Zou et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen

(2018) Hwee Ying Lim et al.   IMMUNITY

Monocytes in rheumatoid arthritis: Circulating precursors of macrophages and osteoclasts and, their heterogeneity and plasticity role in RA pathogenesis

(2018) Amit Kumar Rana et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development

(2018) Hooi-Yeen Yap et al.   Cells

Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells

(2017) Allison W. Roberts et al.   IMMUNITY

MiR-338-5p Promotes Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Targeting SPRY1

(2017) Yan Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Establishment of an in vitro three-dimensional model for cartilage damage in rheumatoid arthritis

(2017) Yvonne Peck et al.   Journal of Tissue Engineering and Regenerative Medicine

Safety, pharmacokinetics, and efficacy of E6011, an antifractalkine monoclonal antibody, in a first-in-patient phase 1/2 study on rheumatoid arthritis

(2017) Yoshiya Tanaka et al.   Modern Rheumatology

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease

(2017) Nathaniel R West et al.   NATURE MEDICINE

Synovial tissue research: a state-of-the-art review

(2017) Carl Orr et al.   Nature Reviews Rheumatology

Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands

(2017) Greg Lemke   TRENDS IN BIOCHEMICAL SCIENCES

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions

(2017) Mojca Frank-Bertoncelj et al.   Nature Communications

CD14+ Cells with the Phenotype of Infiltrated Monocytes Consist of Distinct Populations Characterized by Anti-inflammatory as well as Pro-inflammatory Activity in Gouty Arthritis

(2017) Ji Hye Jeong et al.   Frontiers in Immunology

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

(2016) Chiara Angiolilli et al.   ANNALS OF THE RHEUMATIC DISEASES

Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis

(2016) Yusuke Matsuo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role

(2016) S.J.B. Snelling et al.   OSTEOARTHRITIS AND CARTILAGE

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes

(2016) Rizi Ai et al.   Nature Communications

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

THU0033 A Functional Inhibitory Role for the GAS6/MERTK Axis in Modulating Synovial Inflammation in Rheumatoid Arthritis

(2015) A. Nerviani et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of the synovial fibroblast in rheumatoid arthritis pathogenesis

(2015) Jason D. Turner et al.   CURRENT OPINION IN RHEUMATOLOGY

Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges

(2015) Josef S. Smolen et al.   Nature Reviews Rheumatology

Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis

(2015) Melissa D. Cantley et al.   RHEUMATOLOGY

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches

(2014) W den Hollander et al.   ANNALS OF THE RHEUMATIC DISEASES

The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts

(2014) Kerstin Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure of a tumour necrosis factor inhibitor: a systematic review and economic evaluation

(2014) K Malottki et al.   HEALTH TECHNOLOGY ASSESSMENT

Diminished soluble levels of growth arrest specific protein 6 and tyrosine kinase receptor Axl in patients with rheumatoid arthritis

(2014) Iman H. Bassyouni et al.   International Journal of Rheumatic Diseases

Modulation of TNF-Induced Macrophage Polarization by Synovial Fibroblasts

(2014) Laura T. Donlin et al.   JOURNAL OF IMMUNOLOGY

Prolonged Tumor Necrosis Factor α Primes Fibroblast-like Synoviocytes in a Gene-Specific Manner by Altering Chromatin

(2014) Christopher Sohn et al.   Arthritis & Rheumatology

Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Angela Lee et al.   ARTHRITIS AND RHEUMATISM

The fibroblast as a therapeutic target in rheumatoid arthritis

(2013) Andrew Filer   CURRENT OPINION IN PHARMACOLOGY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

DNA methylome signature in rheumatoid arthritis

(2012) Kazuhisa Nakano et al.   ANNALS OF THE RHEUMATIC DISEASES

The role of stromal cells in the persistence of chronic inflammation

(2012) A. J. Naylor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Pathological Role of Fractalkine/CX3CL1 in Rheumatic Diseases: A Unique Chemokine with Multiple Functions

(2012) Brian Jones et al.   Frontiers in Immunology

DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts

(2011) E Karouzakis et al.   GENES AND IMMUNITY

Why does chronic inflammation persist: An unexpected role for fibroblasts

(2011) Christopher D. Buckley   IMMUNOLOGY LETTERS

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like factor 4 regulates macrophage polarization

(2011) Xudong Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ex Vivo Soft-Laser Treatment Inhibits the Synovial Expression of Vimentin and α-Enolase, Potential Autoantigens in Rheumatoid Arthritis

(2011) Géza Bálint et al.   PHYSICAL THERAPY

Cadherin-11 regulates fibroblast inflammation

(2011) S. K. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation

(2010) Joanna Stanczyk et al.   ARTHRITIS AND RHEUMATISM

TNF-α, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages

(2010) Federica Alciato et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Autophagy induction and CHOP under-expression promotes survival of fibroblasts from rheumatoid arthritis patients under endoplasmic reticulum stress

(2010) Yong-Joo Shin et al.   ARTHRITIS RESEARCH & THERAPY

Cadherin 11 promotes invasive behavior of fibroblast-like synoviocytes

(2009) Hans P. Kiener et al.   ARTHRITIS AND RHEUMATISM

DNA hypomethylation in rheumatoid arthritis synovial fibroblasts

(2009) Emmanuel Karouzakis et al.   ARTHRITIS AND RHEUMATISM

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Overexpression ofREIC/Dkk-3in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7

(2009) Masakiyo Sakaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synovial fibroblasts spread rheumatoid arthritis to unaffected joints

(2009) Stephanie Lefèvre et al.   NATURE MEDICINE

How antirheumatic drugs protect joints from damage in rheumatoid arthritis

(2008) Georg Schett et al.   ARTHRITIS AND RHEUMATISM