Article
Endocrinology & Metabolism
Yeyong Zhang, Shufeng Li, Feng Zhuo, Hongxing Wang, Xiubin Geng, Bing Xu, Luxu Yin, Huaqiang Sun, Xinfeng Yan
Summary: The study found reduced VDBP expression in the synovial tissue and fluid of RA patients, and both VDBP and 1,25(OH)2D3 inhibited the viability and promoted apoptosis of RASF. The combination of VDBP and 1,25(OH)2D3 had a synergistic effect on RASF viability and apoptosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Yan Zhao, Xialin Sun, Jun Lin, Tingwen Zhang, Shuangli Liu, Zhaowei Yan
Summary: Panaxynol (PAL) can promote apoptosis and inhibit proliferation, migration, and invasion of fibroblast-like synovial cells in rheumatoid arthritis (RA). PAL can also reduce joint swelling and inflammatory infiltration in CIA rats, mainly through the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Liyun Cheng, Yanyan Wang, Ruihe Wu, Tingting Ding, Hongwei Xue, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: Single-cell RNA sequencing (scRNA-seq) technology has the potential to make significant breakthroughs in the study of synovial cell differentiation and development, subset identification, functional analysis, and new therapeutic targets in rheumatoid arthritis (RA).
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Maria Jose Alcaraz
Summary: Synovial cells, especially activated synovial fibroblasts, are key players in joint destruction in rheumatoid arthritis. Identifying SF phenotypes, controlling epigenetic changes, and modulating cellular functions are promising approaches to develop novel therapeutic targets for preserving joint architecture and function in RA. Further research is needed to determine the most relevant targets for drug development.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yayun Xu, Zhuoyan Zai, Zheng Lu, Tao Zhang, Longfei Wang, Xuewen Qian, Jingjing Tao, Xiaoqing Peng, Yihao Zhang, Feihu Chen
Summary: The circCDKN2B-AS_006/miR-1258/RUNX1 axis plays a crucial role in promoting the tumor-like growth and metastasis of RASFs in rheumatoid arthritis. Inhibition of circCDKN2B-AS_006 expression alleviates arthritis severity and inhibits aggressive behaviors of RASFs in a mouse model. This study highlights the importance of circRNAs in the pathogenesis of RA and provides a potential therapeutic target for its treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Shuo Zhang, Tao Zhang, Yayun Xu, Genxiang Rong, Juehua Jing
Summary: In patients with rheumatoid arthritis, the levels of NUCB2 mRNA are significantly elevated in the synovium and are associated with gene signatures related to the cell cycle and DNA replication. Inhibition of NUCB2 effectively suppresses the proliferation, migration, and invasion of RASFs.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Kai Qian, Xue-Xia Zheng, Chen Wang, Wen-Guang Huang, Xiao-Bao Liu, Shu-Di Xu, Dan-Kai Liu, Min-Ying Liu, Chang-Song Lin
Summary: The study found that beta-sitosterol (BSS) has potential as a treatment for rheumatoid arthritis (RA) by suppressing the proliferation and migration of endothelial cells, thereby alleviating joint swelling and bone destruction. BSS also prevents synovial angiogenesis by inhibiting VEGFR2 and p-VEGFR2 expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chuyu Shen, Meilin Xu, Siqi Xu, Shuoyang Zhang, Wei Lin, Hao Li, Shan Zeng, Qian Qiu, Liuqin Liang, Youjun Xiao, Hanshi Xu
Summary: This study investigated the role and mechanism of Myricitrin (Myr) in regulating synovitis and joint destruction mediated by fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). The results showed that Myr treatment inhibited the migration and invasion of RA FLS, reduced the expression of inflammatory cytokines and MMPs, and suppressed the phosphorylation of AKT. Furthermore, Myr administration relieved arthritis symptoms in a mouse model of collagen-induced arthritis (CIA).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Maximilian Kugler, Mirjam Dellinger, Felix Kartnig, Lena Mueller, Teresa Preglej, Leonhard X. Heinz, Elisabeth Simader, Lisa Goeschl, Stephan E. Puchner, Sebastian Weiss, Lisa E. Shaw, Matthias Farlik, Wolfgang Weninger, Giulio Superti-Furga, Josef S. Smolen, Guenter Steiner, Daniel Aletaha, Hans P. Kiener, Myles J. Lewis, Costantino Pitzalis, Anela Tosevska, Thomas Karonitsch, Michael Bonelli
Summary: Activated FLS play a critical role in synovial tissue remodeling and interaction with immune cells in rheumatoid arthritis (RA). Co-culture experiments demonstrated that cytokine-activated FLS enhance T cell activation, proliferation, and differentiation. Transcriptomic analysis revealed a correlation between FLS cytokine signatures and infiltrating CD4(+) T cells in RA synovial tissue. ICAM1 was identified as an important mediator in TNF-mediated FLS-T cell interaction.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Cong-Qiu Chu
Summary: Synovial fibroblasts in rheumatoid arthritis play a critical role in chronic inflammation, but current therapies do not directly target these cells. Recent advancements in technology have enabled us to gain a better understanding of the subpopulations and functions of these fibroblasts, leading to the development of targeted therapies.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Yilin Wang, Piaopiao Pan, Aneesah Khan, Caglar Cil, Miguel A. Pineda
Summary: Synovial fibroblasts play a critical role in perpetuating chronic joint inflammation in Rheumatoid Arthritis, and the level of sialic acid on their surface can change in response to extracellular signals. Desialylation of synovial fibroblasts leads to dysregulated migratory ability, activation of inflammatory phenotype, and altered expression of sialyltransferases. The findings suggest that sialic acid plays a key role in modulating homeostatic and inflammatory responses in synovial fibroblasts and contributes to local inflammation in arthritic joints.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Donghao Gan, Wenxiang Cheng, Liqing Ke, Antonia RuJia Sun, Qingyun Jia, Jianhai Chen, Jietao Lin, Jian Li, Zhanwang Xu, Peng Zhang
Summary: Clinical studies have shown that pirfenidone effectively relieves joint pain in rheumatoid arthritis patients. This study investigated the repurposing of pirfenidone for RA treatment and explored its anti-rheumatic mechanisms. Through in vivo and in vitro models, the study suggested that pirfenidone may alleviate pathological changes in RA by inhibiting inflammation and angiogenesis through multiple pathways such as JAK2/STAT3 and Akt.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Lihang Wang, Yun Wang, Tingsheng Lu, Chunshan Luo, Bing Qiu, Shishu Huang, Yunfeng Lin
Summary: In the treatment of rheumatoid arthritis, tetrahedral framework nucleic acid loaded miR-23b (T-23b) inhibits systemic and synovial inflammation by suppressing the production of multiple inflammatory cytokines. It also prohibits osteoclastic activity and cartilage matrix degradation to help protect joint structure by regulating the expression of related genes at the transcriptional level.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Naoki Iwamoto, Kaori Furukawa, Yushiro Endo, Toshimasa Shimizu, Remi Sumiyoshi, Masataka Umeda, Tomohiro Koga, Shin-ya Kawashiri, Takashi Igawa, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Atsushi Kawakami
Summary: The study revealed that MTX treatment altered the expression of 13 miRNAs, with miR-877-3p being upregulated. MiR-877-3p was found to reduce the production of GM-CSF and CCL3 in RA-FLS, as well as inhibit their migratory and proliferative activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Mari Kamiya, Fumitaka Mizoguchi, Akito Takamura, Naoki Kimura, Kimito Kawahata, Hitoshi Kohsaka
Article
Immunology
Paul R. Dunbar, Emily K. Cartwright, Alexander N. Wein, Tetsuo Tsukamoto, Zheng-Rong Tiger Li, Nivedha Kumar, Ida E. Uddback, Sarah L. Hayward, Satoshi Ueha, Shiki Takamura, Jacob E. Kohlmeier
MUCOSAL IMMUNOLOGY
(2020)
Article
Infectious Diseases
Yasunori Iwata, Kenji Satou, Kengo Furuichi, Ikuko Yoneda, Takuhiro Matsumura, Masahiro Yutani, Yukako Fujinaga, Atsushi Hase, Hidetoshi Morita, Toshiko Ohta, Yasuko Senda, Yukiko Sakai-Takemori, Taizo Wada, Shinichi Fujita, Taito Miyake, Haruka Yasuda, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Taro Miyagawa, Akinori Hara, Miho Shimizu, Yasutaka Kamikawa, Kazuho Ikeo, Shigeyuki Shichino, Satoshi Ueha, Takuya Nakajima, Kouji Matsushima, Shuichi Kaneko, Takashi Wada
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Infectious Diseases
Yasunori Iwata, Norihiko Sakai, Ikuko Yoneda, Kenji Satou, Kengo Furuichi, Yasuko Senda, Yukiko Sakai-Takemori, Taizo Wada, Shinichi Fujita, Hisahiro Ogura, Kouichi Sato, Taichiro Minami, Kaori Yamaguchi, Shinji Kitajima, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Akinori Hara, Miho Shimizu, Yoshio Sakai, Kazuho Ikeo, Shigeyuki Shichino, Satoshi Ueha, Takuya Nakajima, Kouji Matsushima, Takashi Wada
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2020)
Article
Neurosciences
Rumi Ueha, Satoshi Ueha, Kenji Kondo, Hironobu Nishijima, Tatsuya Yamasoba
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Mattias N. D. Svensson, Martina Zoccheddu, Shen Yang, Gyrid Nygaard, Christian Secchi, Karen M. Doody, Kamil Slowikowski, Fumitaka Mizoguchi, Frances Humby, Rebecca Hands, Eugenio SanteIli, Cristiano Sacchetti, Kuninobu Wakabayashi, Dennis J. Wu, Christopher Barback, Rizi Ai, Wei Wang, Gary P. Sims, Piotr Mydel, Tsuyoshi Kasama, David L. Boyle, Francesco Galimi, David Vera, Michel L. Tremblay, Soumya Raychaudhuri, Michael B. Brenner, Gary S. Firestein, Costantino Pitzalis, Anna-Karin H. Ekwall, Stephanie Stanford, Nunzio Bottini
Letter
Otorhinolaryngology
Rumi Ueha, Kenji Kondo, Ryoji Kagoya, Shigeyuki Shichino, Satoshi Ueha, Tatsuya Yamasoba
Article
Rheumatology
Sae Ochi, Fumitaka Mizoguchi, Kazuhisa Nakano, Yoshiya Tanaka
Summary: This study analyzed the efficacy and safety of biologic/targeted synthetic disease-modifying antirheumatic drugs in elderly-onset rheumatoid arthritis (EORA) and non-EORA elderly patients, finding no significant differences in disease activity and reasons for drug discontinuation between the two groups. The study also identified three response patterns to b/tsDMARDs over a 54-week period, with similar response trajectories between EORA and non-EORA elderly patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Takashi Nishina, Yutaka Deguchi, Daisuke Ohshima, Wakami Takeda, Masato Ohtsuka, Shigeyuki Shichino, Satoshi Ueha, Soh Yamazaki, Mika Kawauchi, Eri Nakamura, Chiharu Nishiyama, Yuko Kojima, Satomi Adachi-Akahane, Mizuho Hasegawa, Mizuho Nakayama, Masanobu Oshima, Hideo Yagita, Kazutoshi Shibuya, Tetuo Mikami, Naohiro Inohara, Kouji Matsushima, Norihiro Tada, Hiroyasu Nakano
Summary: IL-11, a member of the IL-6 family of cytokines, plays a role in tumor development. IL-11(+) cells are present in murine tumor and acute colitis models and induce the activation of colonic fibroblasts and epithelial cells. IL-11(+) fibroblasts contribute to a feed-forward loop between tumor cells and fibroblasts in the tumor microenvironment, affecting the development of colitis and colon cancer.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Hiroyasu Aoki, Satoshi Ueha, Yoshiaki Nakamura, Shigeyuki Shichino, Hiromichi Nakajima, Manami Shimomura, Akihiro Sato, Tetsuya Nakatsura, Takayuki Yoshino, Kouji Matsushima
Summary: The study indicates that the overlap of T-cell clones between blood and tumor may serve as a potential biomarker to predict clinical response to PD-1 blockade and guide patient selection before treatment.
Article
Rheumatology
Tadashi Hosoya, Tetsuya Saito, Hiroyuki Baba, Nao Tanaka, Seiji Noda, Youji Komiya, Yasuhiro Tagawa, Akio Yamamoto, Fumitaka Mizoguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka, Shinsuke Yasuda
Summary: This study reveals that inhibiting CDK4/6 activity can attenuate cartilage destruction and MMP-3 production, providing chondroprotective effects. These effects were achieved by impairing AP-1 transcriptional activity and destabilizing JUN.
Article
Rheumatology
Akio Yamamoto, Tetsuya Saito, Tadashi Hosoya, Kimito Kawahata, Yoshihide Asano, Shinichi Sato, Fumitaka Mizoguchi, Shinsuke Yasuda, Hitoshi Kohsaka
Summary: This study demonstrates the therapeutic effect of a CDK4/6 inhibitor on dermal fibrosis and its combination with a TGFβR inhibitor shows additive antifibrotic effects. CDK4/6 inhibitors may represent novel agents for the treatment of SSc.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Oncology
Hiroyasu Aoki, Mikiya Tsunoda, Haru Ogiwara, Haruka Shimizu, Haruka Abe, Tatsuro Ogawa, Takaya Abe, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Summary: The tumor-infiltrating T-cell repertoire is a new method for characterizing effective antitumor T-cell responses. In tumor-bearing mice treated with mono-clonal anti-programmed death-ligand 1 (PD-L1) or anti-CD4, the polyclonal fraction of the tumor-reactive T-cell repertoire, consisting of relatively minor clones, increased, which correlated with antitumor effects.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Multidisciplinary Sciences
Kouji Matsushima, Shigeyuki Shichino, Satoshi Ueha, Shizuo Akira
Summary: Inflammation is a defense response to invading stimuli, but excessive and persistent inflammation can lead to tissue injury and organ damage. Excessive inflammation is associated with human diseases. The discovery of chemotactic cytokines in the late 1980s paved the way for understanding the molecular mechanisms of inflammation. This review provides a historical overview of chemokine research over the last 35 years.
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Hisashi Ueta, Xue-Dong Xu, Bin Yu, Yusuke Kitazawa, Enqiao Yu, Yoshiaki Hara, Miwa Morita-Nakagawa, Shu Zhou, Yasushi Sawanobori, Satoshi Ueha, Kazuhito Rokutan, Toshiya Tanaka, Nobuko Tokuda, Kouji Matsushima, Kenjiro Matsuno
Summary: Using DST-antibodies and anti-donor MHCII antibodies can suppress CD8(+) T cell-mediated liver transplant rejection by depleting donor immunogenic DCs and blocking direct or semi-direct pathways of antigen recognition. Donor MHCII-specific antibodies may serve as a selective suppressant of anti-donor immunity for clinical liver transplantation without causing cellular damage to donor MHCII-graft cells and recipient cells.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)