Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Observations on the use of Bruton’s tyrosine kinase inhibitors in SAR-CoV-2 and cancer

(2021) Brooke Benner et al.   Journal of Hematology & Oncology

Second generation BTK inhibitors impair the anti‐fungal response of macrophages and neutrophils

(2020) Ana Colado et al.   AMERICAN JOURNAL OF HEMATOLOGY

The effect of ibrutinib on neutrophil and γδ T cell functions

(2020) Denise Risnik et al.   LEUKEMIA & LYMPHOMA

Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

(2020) Mark Roschewski et al.   Science Immunology

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

(2020) Caroline E. O'Riordan et al.   Frontiers in Immunology

Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

(2019) Alexander P. de Porto et al.   MOLECULAR MEDICINE

Platelet Btk is Required for Maintaining Lung Vascular Integrity during Murine Pneumococcal Pneumosepsis

(2019) Theodora Claushuis et al.   THROMBOSIS AND HAEMOSTASIS

L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling

(2019) Aleksandar Ivetic et al.   Frontiers in Immunology

Effects of BTK signalling in pathogenic microorganism infections

(2019) Bingjue Ye et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury

(2018) Jon M. Florence et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Systematic review of infectious events with the Bruton tyrosine kinase inhibitor ibrutinib in the treatment of hematologic malignancies

(2018) Benjamin F. Tillman et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia

(2018) Florry E van den Boogaard et al.   JOURNAL OF INFECTIOUS DISEASES

Streptococcus pneumoniae’s Virulence and Host Immunity: Aging, Diagnostics, and Prevention

(2018) Lavida R. K. Brooks et al.   Frontiers in Immunology

Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form

(2018) Janka Zsófia Csepregi et al.   JOURNAL OF IMMUNOLOGY

The critical role of myeloperoxidase in Streptococcus pneumoniae clearance and tissue damage during mouse acute otitis media

(2017) Yun Xiang et al.   Innate Immunity

Splenic Ly6G high mature and Ly6G int immature neutrophils contribute to eradication of S. pneumoniae

(2017) Justin F. Deniset et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Hard(y) Look at B-1 Cell Development and Function

(2017) Nicole Baumgarth   JOURNAL OF IMMUNOLOGY

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

(2017) Greiciely O. Andre et al.   Frontiers in Microbiology

Promoter Specificity and Efficacy in Conditional and Inducible Transgenic Targeting of Lung Macrophages

(2017) Alexandra L. McCubbrey et al.   Frontiers in Immunology

Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity

(2017) Alexander N. R. Weber et al.   Frontiers in Immunology

The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation

(2016) Stephanie Volmering et al.   IMMUNITY

Composition of the gut microbiota modulates the severity of malaria

(2016) Nicolas F. Villarino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells

(2015) Natsuo Yamamoto et al.   IMMUNOLOGY

Regulation of Neutrophilic Inflammation by Proteinase-Activated Receptor 1 during Bacterial Pulmonary Infection

(2015) Ricardo J. José et al.   JOURNAL OF IMMUNOLOGY

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

(2015) Minako Ito et al.   Nature Communications

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

(2014) Clare L. Abram et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Natural Antibodies Bridge Innate and Adaptive Immunity

(2014) Saswati Panda et al.   JOURNAL OF IMMUNOLOGY

Triggering receptor expressed on myeloid cells-1 (TREM-1) improves host defence in pneumococcal pneumonia

(2014) Tijmen J Hommes et al.   JOURNAL OF PATHOLOGY

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia

(2014) Ahmed Achouiti et al.   THORAX

The Triggering Receptor Expressed on Myeloid Cells 2 Inhibits Complement Component 1q Effector Mechanisms and Exerts Detrimental Effects during Pneumococcal Pneumonia

(2014) Omar Sharif et al.   PLoS Pathogens

Brutonˈs tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system

(2013) Gabriela López-Herrera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Bruton's Tyrosine Kinase (BTK) and Vav1 Contribute to Dectin1-Dependent Phagocytosis of Candida albicans in Macrophages

(2013) Karin Strijbis et al.   PLoS Pathogens

Pneumococcal Pneumonia

(2012) David H. Dockrell et al.   CHEST

The Role of the Tec Kinase Bruton's Tyrosine Kinase (Btk) in Leukocyte Recruitment

(2012) Helena Block et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

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(2012) Arie Hoogendijk et al.   MOLECULAR MEDICINE

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

(2012) Fumiko Honda et al.   NATURE IMMUNOLOGY

Btk is a positive regulator in the TREM-1/DAP12 signaling pathway

(2011) T. Ormsby et al.   BLOOD

Recognition of Streptococcus pneumoniae by the innate immune system

(2011) Uwe Koppe et al.   CELLULAR MICROBIOLOGY

Immunoglobulin treatment in primary antibody deficiency

(2011) L.J. Maarschalk-Ellerbroek et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin  L 2-mediated slow leukocyte rolling

(2010) T. Yago et al.   BLOOD

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia

(2010) K. Fiedler et al.   BLOOD

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC)  2 and PI3K  pathways

(2010) H. Mueller et al.   BLOOD

TLR signaling and effector functions are intact in XLA neutrophils

(2010) Thomas U. Marron et al.   CLINICAL IMMUNOLOGY

Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection

(2009) J. A. Van Ziffle et al.   BLOOD

Reactive Oxygen Species Regulate Neutrophil Recruitment and Survival in Pneumococcal Pneumonia

(2008) Helen M. Marriott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE