Recognition of Streptococcus pneumoniae by the innate immune system

Invasive Bacterial Pathogens Exploit TLR-Mediated Downregulation of Tight Junction Components to Facilitate Translocation across the Epithelium

(2011) Thomas B. Clarke et al.   Cell Host & Microbe

Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis

(2011) Matthew T. Sorbara et al.   IMMUNOLOGICAL REVIEWS

Cytoplasmic DNA innate immune pathways

(2011) Glen N. Barber   IMMUNOLOGICAL REVIEWS

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice

(2011) Kimberly M. Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

Streptococcus pneumoniae Stimulates a STING- and IFN Regulatory Factor 3-Dependent Type I IFN Production in Macrophages, which Regulates RANTES Production in Macrophages, Cocultured Alveolar Epithelial Cells, and Mouse Lungs

(2011) U. Koppe et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

Critical Roles of ASC Inflammasomes in Caspase-1 Activation and Host Innate Resistance to Streptococcus pneumoniae Infection

(2011) R. Fang et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

(2011) Tobias Hoegen et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 2 Mediates Fatal Immunopathology in Mice During Treatment of Secondary Pneumococcal Pneumonia Following Influenza

(2011) Åsa Karlström et al.   JOURNAL OF INFECTIOUS DISEASES

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract

(2011) D. Parker et al.   mBio

Innate Immune Sensing of DNA

(2011) Shruti Sharma et al.   PLoS Pathogens

Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung

(2010) Bastian Opitz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta‐Analysis

(2010) Daniel M. Weinberger et al.   CLINICAL INFECTIOUS DISEASES

Streptococcus pneumoniae: virulence factors and variation

(2010) A.M. Mitchell et al.   CLINICAL MICROBIOLOGY AND INFECTION

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Streptococcus pneumoniae nasopharyngeal colonization induces type I interferons and interferon-induced gene expression

(2009) Elizabeth A Joyce et al.   BMC GENOMICS

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

(2009) Russell E. Vance et al.   Cell Host & Microbe

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenesis, treatment, and prevention of pneumococcal pneumonia

(2009) Tom van der Poll et al.   LANCET

Role of Toll-Like Receptors 2 and 4 in Pulmonary Inflammation and Injury Induced by Pneumolysin in Mice

(2009) Mark C. Dessing et al.   PLoS One

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Critical Involvement of Pneumolysin in Production of Interleukin-1  and Caspase-1-Dependent Cytokines in Infection with Streptococcus pneumoniae In Vitro: a Novel Function of Pneumolysin in Caspase-1 Activation

(2008) S. Shoma et al.   INFECTION AND IMMUNITY

Innate Immunity to Pneumococcal Infection of the Central Nervous System Depends on Toll‐Like Receptor (TLR) 2 and TLR4

(2008) Matthias Klein et al.   JOURNAL OF INFECTIOUS DISEASES

Streptococcus pneumoniaeDeficient in Pneumolysin or Autolysin Has Reduced Virulence in Meningitis

(2008) Robert A. Hirst et al.   JOURNAL OF INFECTIOUS DISEASES

Role Played by Toll‐Like Receptors 2 and 4 in Lipoteichoic Acid–Induced Lung Inflammation and Coagulation

(2008) Mark C. Dessing et al.   JOURNAL OF INFECTIOUS DISEASES

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE