Similarities and Differences: A Comparative Review of the Molecular Mechanisms and Effectors of NAFLD and AFLD

Once-Weekly Semaglutide in Adults with Overweight or Obesity

(2021) John P.H. Wilding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of Metformin-Single Therapy on the Level of Inflammatory Markers in Serum of Non-Obese T2DM Patients with NAFLD

(2021) Bojan Mitrovic et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

Causes of mortality in Non-Alcoholic Fatty Liver Disease (NAFLD) and Alcohol related Fatty Liver Disease (AFLD).

(2020) Michael P Johnston et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver Disease, Steatohepatitis and Hepatocellular Carcinoma

(2020) Tatsuo Kanda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactobacillus and Pediococcus ameliorate progression of non-alcoholic fatty liver disease through modulation of the gut microbiome

(2020) Na Young Lee et al.   Gut Microbes

Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency

(2020) Mingxing Huang et al.   LABORATORY INVESTIGATION

Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions

(2020) Yoon-Mi Han et al.   Biomed Research International

Blueberry polyphenols play a preventive effect on alcoholic fatty liver disease C57BL/6 J mice by promoting autophagy to accelerate lipolysis to eliminate excessive TG accumulation in hepatocytes

(2020) Qun Zhuge et al.   Annals of Palliative Medicine

Higher flavonoid intake is associated with a lower progression risk of non-alcoholic fatty liver disease in adults: a prospective study

(2020) Qing-wei Zhong et al.   BRITISH JOURNAL OF NUTRITION

miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder

(2020) Lei Fan et al.   JOURNAL OF HEPATOLOGY

The chemical constituents of Gentiana macrophylla pall. under acidic condition using gentiopicroside-rich secoiridoids extract

(2020) Rong Huang et al.   Phytochemistry Letters

Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway

(2020) Chunxu Luo et al.   PHYTOTHERAPY RESEARCH

Apple polyphenol extract alleviates lipid accumulation in free‐fatty‐acid‐exposed HepG2 cells via activating autophagy mediated by SIRT1 / AMPK signaling

(2020) Deming Li et al.   PHYTOTHERAPY RESEARCH

Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease

(2020) Stefan Traussnigg et al.   WIENER KLINISCHE WOCHENSCHRIFT

Hepatocyte-specific TAZ deletion downregulates p62/ Sqstm1 expression in nonalcoholic steatohepatitis

(2020) Xiaoming Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A High-Fat Diet Attenuates Amp-Activated Protein Kinase α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development in Vivo

(2020) Chenghui Yan et al.   DIABETES

IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice

(2020) Zhihao Wang et al.   CYTOKINE

Quercetin mitigates ethanol-induced hepatic steatosis in zebrafish via P2X7R-mediated PI3K/ Keap1/Nrf2 signaling pathway

(2020) Xingtao Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-α signaling in obese mice

(2020) Tiego Aparecido Diniz et al.   LIFE SCIENCES

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

(2020) Philip N. Newsome et al.   NEW ENGLAND JOURNAL OF MEDICINE

PPAR-γ Activation Exerts an Anti-inflammatory Effect by Suppressing the NLRP3 Inflammasome in Spinal Cord-Derived Neurons

(2019) Qing-Qi Meng et al.   MEDIATORS OF INFLAMMATION

Global Liver Disease Burdens and Research Trends: Analysis from a China Perspective

(2019) Jia Xiao et al.   JOURNAL OF HEPATOLOGY

The LRP6 functional mutation rs2302685 contributes to individual susceptibility to alcoholic liver injury related to the Wnt/β-catenin-TCF1-CYP2E1 signaling pathway

(2019) Ying Xu et al.   ARCHIVES OF TOXICOLOGY

Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis

(2019) Fudi Zhong et al.   CELL RESEARCH

LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet

(2019) Tao Hao et al.   Molecular Medicine Reports

Alkoholos májbetegség: a genetikai-epigenetikai tényezők szerepe és az absztinencia hatása

(2019) Alajos Pár et al.   ORVOSI HETILAP

Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in a mouse model of gestational diabetes

(2019) Saraid McIlvride et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Protocatechuic Acid-Mediated miR-219a-5p Activation Inhibits the p66shc Oxidant Pathway to Alleviate Alcoholic Liver Injury

(2019) Rong Fu et al.   Oxidative Medicine and Cellular Longevity

Puerarin protects against high‐fat high‐sucrose diet‐induced non‐alcoholic fatty liver disease by modulating PARP‐1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis

(2019) Shuai Wang et al.   PHYTOTHERAPY RESEARCH

Randomized, Double-blind, Placebo-controlled Study of a Multispecies Probiotic Mixture in Nonalcoholic Fatty Liver Disease

(2019) Sang Bong Ahn et al.   Scientific Reports

Impact of Fecal Microbiota Transplantation on Obesity and Metabolic Syndrome—A Systematic Review

(2019) Zhang et al.   Nutrients

Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease

(2019) Seyed Reza Mirhafez et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Physiopathologie des stéatoses hépatiques métaboliques

(2019) Rodolphe Anty et al.   PRESSE MEDICALE

Gastrointestinal peptides and nonalcoholic fatty liver disease

(2019) Giovanni Tarantino et al.   Current Opinion in Endocrinology Diabetes and Obesity

Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?

(2019) Maria L. Petroni et al.   Nutrients

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway

(2019) Xiao Liu et al.   Frontiers in Pharmacology

Nonalcoholic Fatty Liver Disease: A Challenge from Mechanisms to Therapy

(2019) Giovanni Tarantino et al.   Journal of Clinical Medicine

Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission

(2019) Shiv K Sarin et al.   Lancet Gastroenterology & Hepatology

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice

(2018) Caixia Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR

(2018) Verena Hiebl et al.   BIOTECHNOLOGY ADVANCES

Inhibition of Rac1 ameliorates neuronal oxidative stress damage via reducing Bcl-2/Rac1 complex formation in mitochondria through PI3K/Akt/mTOR pathway

(2018) Yundan Pan et al.   EXPERIMENTAL NEUROLOGY

Hepatic leukocyte immunoglobulin-like receptor B4 (LILRB4) attenuates nonalcoholic fatty liver disease via SHP1-TRAF6 pathway

(2018) Yao Lu et al.   HEPATOLOGY

Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK–SERCA2b pathway

(2018) Tae Woo Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetics and epigenetics of NAFLD and NASH: Clinical impact

(2018) Mohammed Eslam et al.   JOURNAL OF HEPATOLOGY

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030

(2018) Chris Estes et al.   JOURNAL OF HEPATOLOGY

LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway

(2018) Xiaoyu Liao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of Farnesoid X Receptor Activation on Arachidonic Acid Metabolism, NF-kB Signaling, and Hepatic Inflammation

(2018) Zhibo Gai et al.   MOLECULAR PHARMACOLOGY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Dehydroleucodine inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest

(2018) S. Abood et al.   PHYTOTHERAPY RESEARCH

Commensal Homeostasis of Gut Microbiota-Host for the Impact of Obesity

(2018) Pengyi Zhang et al.   Frontiers in Physiology

Modulating NRF2 in Disease: Timing Is Everything

(2018) Matthew Dodson et al.   Annual Review of Pharmacology and Toxicology

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice

(2018) Chian-Jiun Liou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury

(2018) Chang Yeob Han et al.   Cell Reports

Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender

(2018) Cristiana Porcu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-alcohol liver disease effect of Gentianae macrophyllae extract through MAPK/JNK/p38 pathway

(2018) Yulei Cui et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Recovery of ethanol-inducedAkkermansia muciniphiladepletion ameliorates alcoholic liver disease

(2017) Christoph Grander et al.   GUT

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Histological parameters and alcohol abstinence determine long-term prognosis in patients with alcoholic liver disease

(2017) Carolin Lackner et al.   JOURNAL OF HEPATOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Collaborative Power of Nrf2 and PPARγ Activators against Metabolic and Drug-Induced Oxidative Injury

(2017) Choongho Lee   Oxidative Medicine and Cellular Longevity

Targeting inflammation for the treatment of alcoholic liver disease

(2017) Ming-Jiang Xu et al.   PHARMACOLOGY & THERAPEUTICS

Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury

(2017) Ping Qiu et al.   TOXICOLOGY LETTERS

Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism

(2017) Ahmed M. ALJohani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury

(2017) Mian Ge et al.   Cell Death & Disease

New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2017) Xu Zhang et al.   Protein & Cell

Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1

(2017) Min You et al.   Current Molecular Pharmacology

Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice

(2017) Martin Alcala et al.   PLoS One

BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis

(2017) Adriana Carino et al.   Scientific Reports

GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK/mTOR pathway

(2016) Qin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

(2016) Xiaobo Wang et al.   Cell Metabolism

Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells

(2016) Lu Zeng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

(S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation

(2016) Eun Jung Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Contribution of Alcoholic and Nonalcoholic Fatty Liver Disease to the Burden of Liver-Related Morbidity and Mortality

(2016) Zobair Younossi et al.   GASTROENTEROLOGY

Altered intestinal microbiota as a major driving force in alcoholic steatohepatitis

(2016) Herbert Tilg et al.   GUT

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

(2016) Shuai Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance

(2016) Lulu Wang et al.   JOURNAL OF LIPID RESEARCH

Does Metabolically Healthy Obesity Exist?

(2016) Araceli Muñoz-Garach et al.   Nutrients

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway

(2015) Jia Xiao et al.   EUROPEAN JOURNAL OF NUTRITION

Insulin resistance alters hepatic ethanol metabolism: studies in mice and children with non-alcoholic fatty liver disease

(2015) Anna Janina Engstler et al.   GUT

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

The Role of Oxidative Stress and Antioxidants in Liver Diseases

(2015) Sha Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte

(2015) Lei Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway

(2015) Linying Shi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) Is a Novel Nutritional Therapeutic Target for Hyperlipidemia, Non-Alcoholic Fatty Liver Disease, and Atherosclerosis

(2015) Gwang-woong Go   Nutrients

Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells

(2014) Baoping Jiang et al.   BRAIN RESEARCH BULLETIN

Beta-catenin signaling in murine liver zonation and regeneration: A Wnt-Wnt situation!

(2014) Jing Yang et al.   HEPATOLOGY

Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes

(2014) S. Saravanan et al.   INFLAMMATION RESEARCH

SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease

(2014) Motoyuki Kohjima et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Obesity, fatty liver disease and intestinal microbiota

(2014) Nur Arslan   WORLD JOURNAL OF GASTROENTEROLOGY

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

(2014) De Huang et al.   Cell Reports

Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism

(2014) Beth M. Palian et al.   PLoS Genetics

Targeting the PI3K/Akt/mTOR Axis by Apigenin for Cancer Prevention

(2013) Xin Tong et al.   Anti-Cancer Agents in Medicinal Chemistry

Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells

(2013) Chia-Hsin Huang et al.   ARCHIVES OF PHARMACAL RESEARCH

Curcumin Attenuates Diet-Induced Hepatic Steatosis by Activating AMP-Activated Protein Kinase

(2013) Min Young Um et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway

(2013) Hai Yan Quan et al.   BIOCHEMICAL PHARMACOLOGY

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats

(2013) Shuai Zhang et al.   FOOD CHEMISTRY

Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance

(2013) Harini Sampath et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global burden of alcoholic liver diseases

(2013) Jürgen Rehm et al.   JOURNAL OF HEPATOLOGY

PARP-1 and gene regulation: Progress and puzzles

(2013) W. Lee Kraus et al.   MOLECULAR ASPECTS OF MEDICINE

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connecting mTORC1 signaling to SREBP-1 activation

(2012) Inan Bakan et al.   CURRENT OPINION IN LIPIDOLOGY

α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase

(2012) W.-L. Chen et al.   DIABETOLOGIA

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication

(2012) Y. Shen et al.   JOURNAL OF NEUROSCIENCE

Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer

(2012) Jianbiao Zhou et al.   MITOCHONDRION

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Nrf2 Inhibits LXRα-Dependent Hepatic Lipogenesis by Competing with FXR for Acetylase Binding

(2011) Hee Yeon Kay et al.   ANTIOXIDANTS & REDOX SIGNALING

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Activation of Liver X Receptors Attenuates Endotoxin-Induced Liver Injury in Mice with Nonalcoholic Fatty Liver Disease

(2011) Yuan Liu et al.   DIGESTIVE DISEASES AND SCIENCES

Nrf2 and PPARγ

(2010) Raju C. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

REVIEW: Plasminogen Activator Inhibitor-1 (PAI-1): A Key Factor Linking Fibrinolysis and Age-Related Subclinical and Clinical Conditions

(2010) Matteo Cesari et al.   Cardiovascular Therapeutics

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

(2010) P. Ferré et al.   DIABETES OBESITY & METABOLISM

Pathogenesis of alcoholic liver disease: the role of nuclear receptors

(2010) Maxwell Afari Gyamfi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin: A Key Adipokine in Alcoholic Fatty Liver

(2009) Min You et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE